Ligand D-glycero-alpha-D-manno-heptose 1-phosphate
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Basic Ligand Information
Molecular Structure

C7H15O10P
D-glycero-alpha-D-manno-heptose 1-phosphate
KMEJCSKJXSBBAN-ZUHYCWGWSA-N
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)
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D-glycero-alpha-D-manno-heptose 1-phosphate + GTP = GDP-D-glycero-alpha-D-manno-heptose + diphosphate
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)
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D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H2O = D-glycero-alpha-D-manno-heptose 1-phosphate + phosphate
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Substrate in Enzyme-catalyzed Reactions (1 result)
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D-glycero-alpha-D-manno-heptose 1-phosphate + GTP = GDP-D-glycero-alpha-D-manno-heptose + diphosphate
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Product in Enzyme-catalyzed Reactions (2 results)
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D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H2O = D-glycero-alpha-D-manno-heptose 1-phosphate + phosphate
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D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H2O = D-glycero-alpha-D-manno-heptose 1-phosphate + phosphate
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Enzyme Kinetic Parameters
References & Links
Literature References (4)
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General assay for enzymes in the heptose biosynthesis pathways using electrospray ionization mass spectrometry
2017
Park, J.; Lee, D.; Seo, E.K.; Ryu, J.S.; Shin, D.H.
Appl. Microbiol. Biotechnol.
101
4521-4532
Crystal structure of D-glycero-alpha-D-manno-heptose-1-phosphate guanylyltransferase from Yersinia pseudotuberculosis
2018
Kim, H.; Park, J.; Kim, S.; Shin, D.H.
Biochim. Biophys. Acta
1866
482-487
GTP preference of D-glycero-alpha-D-manno-heptose-1-phosphate guanylyltransferase from Yersinia pseudotuberculosis
2019
Kim, S.; Kim, M.S.; Jo, S.; Shin, D.H.
Int. J. Mol. Sci.
21
280
A study of a potent inhibitor against a GDP-6-deoxy-alpha-D-manno-heptose biosynthesis pathway as antibiotic candidates
2020
Kim, S.; Jo, S.; Kim, M.S.; Shin, D.H.
Microb. Drug Resist.
26
385-390
Links to other databases for D-glycero-alpha-D-manno-heptose 1-phosphate