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Ligand UDP-4-amino-4-deoxy-beta-L-arabinopyranose Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information Molecular Structure
C1 4 H2 3 N3 O1 5 P2
UDP-4-amino-4-deoxy-beta-L-arabinopyranose
GWBAKYBSWHQNMQ-IAZOVDBXSA-N
UDP-4-amino-4-deoxy-beta-L-arabinose, UDP-L-Ara4N
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
10-formyltetrahydrofolate + UDP-4-amino-4-deoxy-beta-L-arabinopyranose = 5,6,7,8-tetrahydrofolate + UDP-4-deoxy-4-formamido-beta-L-arabinopyranose
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
UDP-beta-L-threo-pentapyranos-4-ulose + L-glutamate = UDP-4-amino-4-deoxy-beta-L-arabinose + 2-oxoglutarate
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Substrate in Enzyme-catalyzed Reactions (1 result)
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10-formyltetrahydrofolate + UDP-4-amino-4-deoxy-beta-L-arabinopyranose = 5,6,7,8-tetrahydrofolate + UDP-4-deoxy-4-formamido-beta-L-arabinopyranose
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Product in Enzyme-catalyzed Reactions (1 result)
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UDP-beta-L-threo-pentapyranos-4-ulose + L-glutamate = UDP-4-amino-4-deoxy-beta-L-arabinose + 2-oxoglutarate
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Enzyme Kinetic Parameters
References & Links Literature References (5)
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Crystal structure and mechanism of the Escherichia coli ArnA (PmrI) transformylase domain. An enzyme for lipid A modification with 4-amino-4-deoxy-L-arabinose and polymyxin resistance
2005
Gatzeva-Topalova, P.Z.; May, A.P.; Sousa, M.C.
Biochemistry
44
5328-5338
Oxidative decarboxylation of UDP-glucuronic acid in extracts of polymyxin-resistant Escherichia coli. Origin of lipid a species modified with 4-amino-4-deoxy-L-arabinose
2001
Breazeale, S.D.; Ribeiro, A.A.; Raetz, C.R.
J. Biol. Chem.
277
2886-2896
A formyltransferase required for polymyxin resistance in Escherichia coli and the modification of lipid A with 4-Amino-4-deoxy-L-arabinose. Identification and function oF UDP-4-deoxy-4-formamido-L-arabinose
2005
Breazeale, S.D.; Ribeiro, A.A.; McClerren, A.L.; Raetz, C.R.
J. Biol. Chem.
280
14154-14167
Structure and function of both domains of ArnA, a dual function decarboxylase and a formyltransferase, involved in 4-amino-4-deoxy-L-arabinose biosynthesis
2005
Williams, G.J.; Breazeale, S.D.; Raetz. C.R.; Naismith. J.H.
J. Biol. Chem.
280
23000-23008
Structure of the Escherichia coli ArnA N-formyltransferase domain in complex with N5-formyltetrahydrofolate and UDP-Ara4N
2016
Genthe, N.A.; Thoden, J.B.; Holden, H.M.
Protein Sci.
25
1555-1562
Links to other databases for UDP-4-amino-4-deoxy-beta-L-arabinopyranose
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