Ligand (Z)-pent-1-ene-1,2,5-tricarboxylate
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Basic Ligand Information
Molecular Structure
C8H10O6
(Z)-pent-1-ene-1,2,5-tricarboxylate
WXZASCSXAMHFCX-PLNGDYQASA-N
(1Z)-pent-1-ene-1,2,5-tricarboxylic acid, cis-(homo)2aconitate, cis-homo2aconitate
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)
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cis-(homo)2aconitate + H2O = (-)-threo-iso(homo)2citrate
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Substrate in Enzyme-catalyzed Reactions (3 results)
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cis-(homo)2aconitate + H2O = (-)-threo-iso(homo)2citrate
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cis-(homo)2aconitate + H2O = ?
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(Z)-pent-1-ene-1,2,5-tricarboxylate = ?
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Product in Enzyme-catalyzed Reactions (1 result)
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dihomocitrate = cis-(homo)2aconitate + H2O
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Enzyme Kinetic Parameters
kcat Value (Turnover Number) (5 results)
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0.66
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pH 9.0, 60°C, recombinant enzyme, hydrolase reaction
0.66
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wild-type HACNMj, pH 7.0, temperature not specified in the publication
2.2
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mutant T27A, pH 7.0, temperature not specified in the publication
5.8
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mutant R26V, pH 7.0, temperature not specified in the publication
6.6
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mutant R26V/T27Y, pH 7.0, temperature not specified in the publication
KM Value (5 results)
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0.03
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pH 9.0, 60°C, recombinant enzyme, hydrolase reaction
0.03
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wild-type HACNMj, pH 7.0, temperature not specified in the publication
0.269
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mutant T27A, pH 7.0, temperature not specified in the publication
0.87
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mutant R26V, pH 7.0, temperature not specified in the publication
1.6
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mutant R26V/T27Y, pH 7.0, temperature not specified in the publication
References & Links
Literature References (2)
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Methanogen homoaconitase catalyzes both hydrolyase reactions in coenzyme B biosynthesis
2008
Drevland, R.M.; Jia, Y.; Palmer, D.R.; Graham, D.E.
J. Biol. Chem.
283
28888-28896
Substrate specificity determinants of the methanogen homoaconitase enzyme: structure and function of the small subunit
2010
Jeyakanthan, J.; Drevland, R.M.; Gayathri, D.R.; Velmurugan, D.; Shinkai, A.; Kuramitsu, S.; Yokoyama, S.; Graham, D.E.
Biochemistry
49
2687-2696
Links to other databases for (Z)-pent-1-ene-1,2,5-tricarboxylate
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