Ligand p-chloromercuribenzenesulfonic acid

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Basic Ligand Information

Molecular Structure
Picture of p-chloromercuribenzenesulfonic acid (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H6ClHgO3S
p-chloromercuribenzenesulfonic acid
XXEBDPRHFAWOND-UHFFFAOYSA-M
Synonyms:
4-chlormercuriphenylsulfonic acid, 4-chloro-mercuriphenylsulfonic acid, 4-chloromercuribenzene sufonic acid, 4-chloromercuribenzenesulfonate, 4-chloromercuribenzene sulfonate, 4-chloromercuribenzenesulfonic acid, 4-Chloromercuriphenylsulfonate, 4-Chloromercuriphenyl sulfonate, 4-chloromercuriphenylsulfonic acid, 4-chloromercuriphenyl sulfonic acid, chloromercuribenzene-p-sulfonic acid, chloromercuribenzene 4-sulfonate, chloromercuriphenylsulfonate, p-(chloromercuri)-benzenesulfonic acid, p-(chloromercuri)benzene sulfonate, p-chlormercuriphenylsulfonic acid, p-chloromercuri-benzene sulfonate, p-chloromercuribenzene-sulfonic acid, p-chloromercuribenzene-sulphonic acid, p-chloromercuribenzene sulfonate, p-chloromercuribenzenesulfonate, p-chloromercuribenzene sulfonic acid, p-chloromercuribenzenesulphonic acid, p-chloromercuric benzene sulfonate, p-chloromercuriphenyl-sulfonic acid, p-chloromercuriphenyl sulfonate, p-chloromercuriphenylsulfonate, p-chloromercuriphenylsulfonic-acid, p-chloromercuriphenyl sulfonic acid, p-chloromercuriphenylsulfonic acid, p-chloromercuriphenylsulphonate, p-chloromercuriphenyl sulphonic acid, p-Chloromercurisulfonic acid, p-chloromercuryphenylsulfonate, p-chloromercuryphenylsulfonic acid, p-Chlororomercuriphenyl sulfonate, p-Choromercuribenzenesulfonate, p-Choromercuriphenylsulfonate, para-chloromercuribenzenesulfonate, pchloromercuriphenylsulfonate, pchloromercuriphenylsulfonic acid, PCMBS

Roles as Enzyme Ligand

Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
inhibits hydrolysis of Gly-Pro-Hyp, activates hydrolysis of bradykinin
-

Inhibitor in Enzyme-catalyzed Reactions (248 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
46% inhibition at 0.1 mM
-
inhibits both activities of the enzyme
-
95% inhibition at 0.1 mM
-
0.001 mM, complete inhibition
-
100% inhibition at 0.05 mM, recombinant enzyme 1 and 2
-
1 mM; 87% inhibition
-
inactivates enzyme completely at 0.1 mM
-
1 mM, 35% inhibition
-
80% inhibition at 0.1 mM
-
98% inhibition at 0.001 mM
-
8 mol per mol enzyme, complete inhibition
-
40% inhibition at 20 mM
-
more than 50% loss in activity in 60 min at 0.05 mM
-
inactivetes, can be reversed by addition of cysteine
-
0.1 mM, complete inhibition of enzyme from cultured aortic smooth muscle cells
-
0.1 mM, complete inhibition
-
60% inhibition at 0.025 mM, inhibition can be reversed by an excess of thiol compounds
-
62% inhibition at 1 mM
-
strong
-
0.02 mM
-
potent inhibition
-
complete inhibition at 1 mM
-
0.16 mM, 97% inhibition
-
complete inhibition, DTT protects
-
50% inhibition of ACAT1 at 0.01 mM, Cys467 is one of the major targets for inhibition
-
activity abolished at 6 mM
-
UGT71F1, 0.01mM, 22% inhibition; UGT73A4 activity is completely inhibited at 0.01mM
-
irreversible
-
46% inhibition at 1 mM
-
inhibition of gamma-elimination
-
reversible by cysteine or 2-mercaptoethanol
-
0.1 mM, completely inhibits 4HB geranyltransferase activity
-
0.02 mM, 92% inhibition, addition of 1 mM glutathione protects to 100%
-
0.025 mM, 80% inhibition of PFK III, reversed by 2-mercaptoethanol, dithiothreitol or reduced glutathione
-
strong inhibition at 0.1 mM
-
50% inhibition at 0.0000038 mM
-
2-mercaptoethanol protects
-
0.2 mM strongly inhibitory
-
20-25% inhibition in presence of 0.0001 M
-
100% inhibition at 1 mM
-
0.1 mM, 98% inhibition
-
41% inhibition at 1 mM
-
weak inhibition
-
strong, with p-nitrophenyl-beta-D-glucopyranoside as substrate
-
potent inhibitor
-
strong inhibition at 1 mM
-
1 mM, 12% inhibition
-
1 mM, 60% inhibition
-
strong inhibition
-
0.1 mM, relative activity: 0%
-
IC50: 0.27 mM
-
1 mM, 15% inhibition
-
0.1 mM and 1 mM, complete inhibition
-
10 mM, 13% inhibition
-
1 mM, 96% inhibition
-
strong inhibition at 0.05 mM
-
27% inhibited by 0.01 mM
-
1 mM, 39% inhibition, addition of 10 mM dithiothreitol restores activity to 100%
-
0.1 mM, complete inhibition
-
complete inhibition
-
strong
-
1 mM, 56% of inhibition
-
10 mM, 50% inhibition
-
86% inhibition at 5 mM
-
complete inhibition at 0.1 mM
-
2 mM, complete inhibition
-
strong inhibition
-
inhibition is reversed by Cys
-
96% inhibition at 1 mM
-
activity is not restored by treatment with 2-mercaptoethanol
-
0.1 mM, 50% inhibition
-
FGK2 complex
-

Enzyme Kinetic Parameters

Ki Value (3 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.05
-
pH 7.2, 25°C
0.025
-
-
0.0025
-
-

IC50 Value (2 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.04
-
IC50: 0.04 mM
0.27
-
IC50: 0.27 mM

References & Links

Links to other databases for p-chloromercuribenzenesulfonic acid

ChEBI
PubChem
ChEBI
PubChem