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Ligand UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-4-hexulose

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

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Show Natural Substrate (3 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.426

UDP-2-acetamido-2,6-dideoxy-alpha-D-xylohex-4-ulose + NAD(P)H + H+ = UDP-N-acetyl-alpha-D-quinovosamine + NAD(P)+

761848

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1.1.1.426

UDP-2-acetamido-2,6-dideoxy-alpha-D-xylohex-4-ulose + NADH + H+ = UDP-N-acetyl-alpha-D-quinovosamine + NAD+

761433, 761449

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1.1.1.426

2 entries

2.6.1.34

UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-4-hexulose + L-glutamate = UDP-4-amino-4,6-dideoxy-alpha-D-N-acetyl-D-glucosamine + 2-oxoglutarate

714160, 692984, 714453

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In Vivo Product in Enzyme-catalyzed Reactions (2 results)

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Show Natural Product (2 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

4.2.1.115

2 UDP-N-acetylglucosamine = UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-4-hexulose + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-4-hexulose + 2 H2O

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4g5h, 3D-view

4.2.1.135

UDP-N-acetyl-alpha-D-glucosamine = UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose + H2O

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Substrate in Enzyme-catalyzed Reactions (3 results)

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Show Substrate (3 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.426

UDP-2-acetamido-2,6-dideoxy-alpha-D-xylohex-4-ulose + NAD(P)H + H+ = UDP-N-acetyl-alpha-D-quinovosamine + NAD(P)+

761848

-

1.1.1.426

UDP-2-acetamido-2,6-dideoxy-alpha-D-xylohex-4-ulose + NADH + H+ = UDP-N-acetyl-alpha-D-quinovosamine + NAD+

761433, 761449

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1.1.1.426

2 entries

2.6.1.34

UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-4-hexulose + L-glutamate = UDP-4-amino-4,6-dideoxy-alpha-D-N-acetyl-D-glucosamine + 2-oxoglutarate

714160, 692984, 714453

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Product in Enzyme-catalyzed Reactions (3 results)

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Show Product (3 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

4.2.1.115

2 UDP-N-acetylglucosamine = UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-4-hexulose + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-4-hexulose + 2 H2O

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4g5h, 3D-view

4.2.1.135

UDP-N-acetylglucosamine = UDP-2-acetamido-2,6-dideoxy-alpha-D-4-ketohexulose + H2O

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-

4.2.1.135

UDP-N-acetyl-alpha-D-glucosamine = UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose + H2O

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4.2.1.135

2 entries

3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

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Show 3D Structure of Enzyme-Ligand-Complex (PDB) (1 entry)

EC NUMBER

ENZYME 3D STRUCTURE

4.2.1.115

4g5h, 3D-view

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (1 result)

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Show Turnover Number (1 entry)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

2.6.1.34

2.4

-

pH 7.7, 37°C

692984

K_M Value (1 result)

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Show KM Value (1 entry)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.6.1.34

0.048

-

pH 7.7, 37°C

692984

References & Links

Literature References (6)

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Show Reference (6 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

692984

16286454

Functional characterization of dehydratase/aminotransferase pairs from Helicobacter and Campylobacter: enzymes distinguishing the pseudaminic acid and bacillosamine biosynthetic pathways

2006

Schoenhofen, I.C.; McNally, D.J.; Vinogradov, E.; Whitfield, D.; Young, N.M.; Dick, S.; Wakarchuk, W.W.; Brisson, J.R.; Logan, S.M.

J. Biol. Chem.

281

723-732

714160

17087520

In vitro biosynthesis of UDP-N,N'-diacetylbacillosamine by enzymes of the Campylobacter jejuni general protein glycosylation system

2006

Olivier, N.B.; Chen, M.M.; Behr, J.R.; Imperiali, B.

Biochemistry

45

13659-13669

714453

21036619

Development of a multicomponent kinetic assay of the early enzymes in the Campylobacter jejuni N-linked glycosylation pathway

2010

Morrison, J.P.; Troutman, J.M.; Imperiali, B.

Bioorg. Med. Chem.

18

8167-8171

761433

14551189

Genetic locus and structural characterization of the biochemical defect in the O-antigenic polysaccharide of the symbiotically deficient Rhizobium etli mutant, CE166 Replacement of N-acetylquinovosamine with its hexosyl-4-ulose precursor

2003

Forsberg, L.; Noel, K.; Box, J.; Carlson, R.

J. Biol. Chem.

278

51347-51359

761449

24817117

In vitro biosynthesis and chemical identification of UDP-N-acetyl-D-quinovosamine (UDP-D-QuiNAc)

2014

Li, T.; Simonds, L.; Kovrigin, E.; Noel, K.

J. Biol. Chem.

289

18110-18120

761848

10627048

Functional analysis of genes responsible for the synthesis of the B-band O antigen of Pseudomonas aeruginosa serotype O6 lipopolysaccharide

1999

Belanger, M.; Burrows, L.; Lam, J.

Microbiology

145

3505-3521

Links to other databases for UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-4-hexulose

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Show Links (1 entry)

ChEBI

PubChem

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