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reversible competitive inhibitor
-
a nonselective reversible MAO inhibitor, inhibits the MAO A S209E mutant with much lower affinity, 160fold and 20fold, respectively, than the wild-type enzyme
-
i.e. 1-phenyl-2-propanamine
-
reversible inhibitor; reversible inhibitor
-
the inhibitor induces changes in the spectrum of MAO A, consistent with stacking of inhibitor with the flavin in the active site. Inhibitor stabilizes the semiquinone form of FAD during reduction of MAO A by dithionite and no further reduction of the inhibitor-MAO A complex occurs
-
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0.006
-
pH 7.5, 25°C, MAO-A
0.0115
-
pH 7.2, 30°C, mutant enzyme C374A
0.0122
-
pH 7.5, 25°C, MAO-A
0.0144
-
pH 7.2, 30°C, wild-type enzyme
0.0144
-
pH 7.4, 37°C, MAO-A
0.015
-
pH and temperature not specified in the publication
0.038
-
at 25°C in 50 mM potassium phosphate, pH 7.4
0.1
-
above, pH 7.5, 25°C, MAO-B
0.28
-
pH 7.4, 37°C, MAO-B
0.506
-
30°C, pH 7, oxidative half-reaction, substrate: 2-phenylethylamine or benzylamine
2.56
-
30°C, pH 7, reductive half-reaction, substrate: 2-phenylethylamine or benzylamine
6
-
isoform MAO A, in 50 mM potassium phosphate assay buffer (pH 7.5), at 25°C
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The kinetic mechanisms of monoamine oxidases A and B
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Ramsay, R.R.; Singer, T.P.
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Monoamine oxidase contains a redox-active disulfide
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A role for p38 mitogen-activated protein kinase in the regulation of the serotonin transporter: evidence for distinct cellular mechanisms involved in transporter surface expression
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2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase B inhibitors
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Luehr, S.; Vilches-Herrera, M.; Fierro, A.; Ramsay, R.R.; Edmondson, D.E.; Reyes-Parada, M.; Cassels, B.K.; Iturriaga-Vasquez, P.
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Catalytic and inhibitor binding properties of zebrafish monoamine oxidase (zMAO): comparisons with human MAO A and MAO B
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Aldeco, M.; Arslan, B.K.; Edmondson, D.E.
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159
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Kinetics, mechanism, and inhibition of monoamine oxidase
2018
Ramsay, R.; Albreht, A.
J. Neural Transm.
125
1659-1683
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