Ligand Bromoacetate

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Basic Ligand Information

Molecular Structure
Picture of Bromoacetate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C2H3BrO2
Bromoacetate
KDPAWGWELVVRCH-UHFFFAOYSA-M
Synonyms:
2-bromoacetic acid, Bromoacetic acid, monobromoacetate, monobromoacetic acid

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
monobromoacetate + H2O = glycolate + HBr
show the reaction diagram
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monobromoacetate + H2O = glycolate + HBr
show the reaction diagram
monobromoacetate + H2O = 2-hydroxyacetate + bromide
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (11 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
monobromoacetate + H2O = glycolate + HBr
show the reaction diagram

Product in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ethyl bromoacetate + H2O = ethanol + bromoacetate
show the reaction diagram
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2-acetamido-2-deoxy-beta-D-glucopyranosyl-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosyl-(1-4)-2-bromoacetamido-2-deoxy-beta-D-glucopyranosyl-(1-4)-2-acetamido-2-deoxy-D-glucose + H2O = GlcNAcbeta(1-4)GlcNAcbeta(1-4)GlcNbeta(1-4)GlcNAc + bromoacetate
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (18 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
noncompetitive inhibition in a dose-dependent manner
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75Se-labeled protein A preparation is inactivated at pH 6, 25°C, for 10 min in presence of 10 mM bromoacetate by about 25%
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slight inhibition of free enzyme
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83% inhibition at 1 mM
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slow, reversible inhibition, substrate offers marked protection
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3D Structure of Enzyme-Ligand-Complex (PDB) (2 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

KM Value (3 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
25
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-

References & Links

Links to other databases for Bromoacetate

ChEBI
PubChem
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PubChem