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BRENDA support

Ligand (R,S)-4-amino-3-fluorobutanoic acid

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Basic Ligand Information

Molecular Structure
Picture of (R,S)-4-amino-3-fluorobutanoic acid (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C4H8FNO2
(R,S)-4-amino-3-fluorobutanoic acid
UNJUEKLVLCDYIR-UHFFFAOYSA-N

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (1 result)

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EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(R,S)-4-amino-3-fluorobutanoic acid = 4-aminobut-2-enoic acid + HF
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (1 result)

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EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
the (R)-enantiomer inhibits the transamination of gamma-aminobutanoic acid 10 times more effectively than the (S)-enantiomer. On binding of free 4-amino-3-fluorobutanoic acid to enzyme the optimal conformation places the C-NH3 + and C-F bonds gauche in the (R)-enantiomer but anti in the (S)-enantiomer
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Enzyme Kinetic Parameters

KM Value (1 result)

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EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.045
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pH 8.5

References & Links

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Links to other databases for (R,S)-4-amino-3-fluorobutanoic acid

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ChEBI
PubChem
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PubChem