Ligand 1-oleoyl-sn-glycerol 3-phosphate

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Basic Ligand Information

Molecular Structure
Picture of 1-oleoyl-sn-glycerol 3-phosphate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C21H41O7P
1-oleoyl-sn-glycerol 3-phosphate
WRGQSWVCFNIUNZ-GDCKJWNLSA-N
Synonyms:
1-(9Z-octadecenoyl)-sn-glycero-3-phosphate, 1-monooleoylglycerol 3-phosphate, 1-oleoyl-2-lyso-phosphatidic acid, 1-oleoyl-2-lyso-sn-glycero-3-phosphate, 1-oleoyl-2-lyso-sn-glycerol 3-phosphate, 1-oleoyl-2-lysophosphatidate, 1-oleoyl-2-lysophosphatidic acid, 1-oleoyl-glycerol-3-phosphate, 1-oleoyl-glycerol 3-phosphate, 1-oleoyl-lysophosphatidic acid, 1-oleoyl-sn-glycerol-3-phosphate, 1-oleoyl-sn-gycerol 3-phosphate, 1-oleoylglycerol 3-phosphate, 1-oleoyl lysophosphatidic acid, oleoyl-LPA, oleoyl-lysophosphatidic acid, oleoyl-sn-glycerol-3-phosphate, oleoyl-sn-glycerol 3-phosphate, oleoyl lysophosphatidic acid, sn-1-oleoylglycerol 3-phosphate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
oleoyl-CoA + 1-oleoyl-lysophosphatidic acid = CoA + 1,2-dioleoyl-sn-lysophosphatidic acid
show the reaction diagram
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oleoyl-CoA + 1-oleoyl-lysophosphatidic acid = CoA + 1,2-dioleoyl-sn-lysophosphatidic acid
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
oleoyl-CoA + sn-glycerol 3-phosphate = CoA + 1-oleoyl-sn-glycerol 3-phosphate
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (43 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
1-oleoyl-sn-glycerol 3-phosphate + 2 reduced ferredoxin [iron-sulfur] cluster + O2 + 2 H+ = 1-linoleoyl-sn-glycerol 3-phosphate + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H2O
show the reaction diagram
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oleoyl-CoA + 1-oleoyl-lysophosphatidic acid = CoA + 1,2-dioleoyl-sn-lysophosphatidic acid
show the reaction diagram
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oleoyl-CoA + 1-oleoyl-lysophosphatidic acid = CoA + 1,2-dioleoyl-sn-lysophosphatidic acid
show the reaction diagram
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1-oleoyl-2-lyso-phosphatidic acid + H2O = sn-glycerol-1-phosphate + oleate
show the reaction diagram
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1-oleoyl lysophosphatidic acid + H2O = 1-oleoyl glycerol + phosphate
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
oleoyl-lysophosphatidylcholine + H2O = 1-oleoyl-sn-gycerol 3-phosphate + choline
show the reaction diagram
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N-arachidonoyl-1-oleoyl-2-lysophosphatidylethanolamine + H2O = N-arachidonoylethanolamine + 1-oleoyl-2-lyso-sn-glycerol 3-phosphate
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
non-competitive, mitochondrial isozyme
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24% inhibition
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (1 result)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
177
-
pH 7.0, 30°C

KM Value (11 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.108
-
pH 7.5, 23°C

Ki Value (3 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.055
-
microsomal enzyme

References & Links

Links to other databases for 1-oleoyl-sn-glycerol 3-phosphate

ChEBI
PubChem
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PubChem