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Ligand genistein

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (5 results)

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Show Natural Substrate (5 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.14.14.89

genistein + [reduced NADPH-hemoprotein reductase] + O2 = 2'-hydroxygenistein + [oxidized NADPH-hemoprotein reductase] + H2O

745660

-

1.14.14.90

genistein + [reduced NADPH-hemoprotein reductase] + O2 = 2'-hydroxygenistein + [oxidized NADPH-hemoprotein reductase] + H2O

746010

-

2.1.1.46

S-adenosyl-L-methionine + genistein = S-adenosyl-L-homocysteine + biochanin A

758013

-

2.4.1.17

UDP-glucuronate + genistein = UDP + genistein beta-D-glucuronoside

737080

-

2.4.1.170

UDP-glucose + genistein = UDP + genistein 7-O-beta-D-glucoside

694783, 721961, 736973, 736979

-

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

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Show Natural Product (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.2.1.161

genistin + H2O = genistein + beta-D-glucopyranose

0

-

Substrate in Enzyme-catalyzed Reactions (57 results)

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Show Substrate (57 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.14.14.1

genistein + [reduced NADPH-hemoprotein reductase] + O2 = 3',8-dihydroxygenistein + [oxidized NADPH-hemoprotein reductase] + H2O

745417

-

1.14.14.88

genistein + NADPH + O2 = ?

660173

-

1.14.14.89

genistein + [reduced NADPH-hemoprotein reductase] + O2 = 2'-hydroxygenistein + [oxidized NADPH-hemoprotein reductase] + H2O

285325, 285323, 745660, 285318

-

1.14.14.90

genistein + [reduced NADPH-hemoprotein reductase] + O2 = 2'-hydroxygenistein + [oxidized NADPH-hemoprotein reductase] + H2O

746010, 285323, 660173

-

2.1.1.150

S-adenosyl-L-methionine + 5,7,4'-trihydroxyisoflavone = S-adenosyl-L-homocysteine + 5,4'-dihydroxy-7-methoxyisoflavone

441446, 441447, 676552, 389479

-

2.1.1.155

S-adenosyl-L-methionine + genistein = S-adenosyl-L-homocysteine + biochanin A

655462

-

2.1.1.231

genistein + S-adenosyl-L-methionine = biochanin A + S-adenosyl-L-homocysteine

655462

-

2.1.1.231

S-adenosyl-L-methionine + genistein = S-adenosyl-L-homocysteine + biochanin A

712526

-

2.1.1.231

2 entries

2.1.1.283

S-adenosyl-L-methionine + genistein = S-adenosyl-L-homocysteine + O-methoxy-genistein

755826

-

2.1.1.46

S-adenosyl-L-methionine + 5,7,4'trihydroxyisoflavone = S-adenosyl-L-homocysteine + 5,7-dihydroxy-4'-O-methylisoflavone

441443

-

2.1.1.46

S-adenosyl-L-methionine + genistein = S-adenosyl-L-homocysteine + biochanin A

758013, 756819

-

2.1.1.46

2 entries

2.1.1.68

S-adenosyl-L-methionine + genistein = ?

485542

-

2.1.1.75

S-adenosyl-L-methionine + genistein = ?

757717

-

2.1.1.88

S-adenosyl-L-methionine + genistein = S-adenosyl-L-homocysteine + O-methoxy-genistein

755826

-

2.1.1.B75

S-adenosyl-L-methionine + 5,7,4'-trihydroxyisoflavone = S-adenosyl-L-homocysteine + 5,4'-dihydroxy-7-methoxyisoflavone

674128

-

2.1.1.B75

2 S-adenosyl-L-methionine + genistein = 2 S-adenosyl-L-homocysteine + O-methylgenistein + O,O'-dimethylgenistein + O,O',O''-trimethylgenistein

755826

-

2.4.1.17

UDP-glucuronate + genistein = UDP + genistein beta-D-glucuronide

659315

-

2.4.1.17

UDP-glucuronate + genistein = UDP + genistein beta-D-glucuronoside

737080

-

2.1.1.B75

2 entries

2.4.1.17

2 entries

2.4.1.170

UDP-glucose + genistein = UDP + genistein 7-O-beta-D-glucoside

674845, 694783, 688645, 721961, 736588, 736973, 736979, 488802

-

2.4.1.19

alpha-cyclodextrin + genistein = genistein monoglucoside + genistein diglucoside + genistein triglucoside + genistein tetraglucoside

757354

-

2.4.1.19

beta-cyclodextrin + genistein = genistein monoglucoside + genistein diglucoside + genistein triglucoside + genistein tetraglucoside

757354

-

2.4.1.19

genistein + alpha-cyclodextrin = genistein monoglucoside + genistein diglucoside + genistein triglucoside + genistein tetraglucoside

757354

-

2.4.1.19

genistein + beta-cyclodextrin = genistein monoglucoside + genistein diglucoside + genistein triglucoside + genistein tetraglucoside

757354

-

2.4.1.19

genistein + D-glucose = genistein monoglucoside + genistein diglucoside + genistein triglucoside + genistein tetraglucoside

757354

-

2.4.1.19

genistein + maltodextrin = alpha-cyclodextrins

755859

-

2.4.1.19

genistein + maltodextrin = genistein monoglucoside + genistein diglucoside + genistein triglucoside + genistein tetraglucoside

757354

-

2.4.1.19

genistein + maltose = genistein monoglucoside + genistein diglucoside + genistein triglucoside + genistein tetraglucoside

757354

-

2.4.1.19

genistein + starch = genistein monoglucoside + genistein diglucoside + genistein triglucoside + genistein tetraglucoside

757354

-

2.4.1.19

genistein + sucrose = genistein monoglucoside + genistein diglucoside + genistein triglucoside + genistein tetraglucoside

757354

-

2.4.1.19

maltodextrin + genistein = genistein monoglucoside + genistein diglucoside + genistein triglucoside + genistein tetraglucoside

757354

-

2.4.1.19

maltose + genistein = genistein monoglucoside + genistein diglucoside + genistein triglucoside + genistein tetraglucoside

757354

-

2.4.1.19

starch + genistein = genistein monoglucoside + genistein diglucoside + genistein triglucoside + genistein tetraglucoside

757354

-

2.4.1.384

UDP-alpha-D-glucose + genistein = ? + UDP

760811, 761005

-

2.4.1.384

UDP-alpha-D-glucose + genistein = genistein 4'-O-glucoside + genistein 7-O-glucoside + genistein 4',7-O-diglucoside + UDP

761566

-

2.4.1.81

2 dTDP-2-deoxy alpha-D-glucose + 2 genistein = 2 dTDP + 7-O-(2-deoxy-beta-D-glucopyranosyl)genistein + 4'-O-(2-deoxy-beta-D-glucopyranosyl)genistein

758337

-

2.4.1.81

dTDP-beta-L-rhamnose + genistein = dTDP + 7-O-(alpha-L-rhamnopyranosyl)genistein

758337

-

2.4.1.81

UDP-galactose + genistein = UDP + 7-O-beta-D-galactosylgenistein

757983

-

2.4.1.81

UDP-glucose + genistein = UDP + 4'-O-(beta-D-glucopyranosyl)genistein + 7-O-(beta-D-glucopyranosyl)genistein

758337

-

2.4.1.81

UDP-glucose + genistein = UDP + 7-O-(beta-D-glucopyranosyl)genistein

758337

-

2.4.1.81

UDP-glucose + genistein = UDP + 7-O-beta-D-glucosylgenistein

757983

-

2.4.1.81

UDP-glucose + genistein = UDP + ?

759388

-

2.4.1.19

13 entries

2.4.1.384

2 entries

2.4.1.81

7 entries

2.4.1.91

UDP-glucose + genistein = UDP + ?

660097

-

2.5.1.111

dimethylallyl diphosphate + genistein = ?

760024

-

2.5.1.36

dimethylallyl diphosphate + genistein = diphosphate + ?

722715

-

2.5.1.80

dimethylallyl diphosphate + genistein = diphosphate + wighteone

722044

-

2.8.2.1

3'-phosphoadenylyl sulfate + genistein = adenosine 3',5'-bisphosphate + ?

671776

-

2.8.2.1

3'-phosphoadenylyl sulfate + genistein = adenosine 3',5'-bisphosphate + genistein 4'-sulfate

761552

-

2.8.2.1

3'-phosphoadenylyl sulfate + genistein = adenosine 3',5'-bisphosphate + genistein 7-sulfate

761552

-

2.8.2.1

3'-phosphoadenylylsulfate + genistein = adenosine 3',5'-bisphosphate + ?

661704

-

2.8.2.1

3'-phosphoadenylylsulfate + genistein = adenosine 3',5'-bisphosphate + genistein 4'-sulfate

661580

-

2.8.2.1

3'-phosphoadenylylsulfate + genistein = adenosine 3',5'-bisphosphate + genistein 7-sulfate + genistein 4'-sulfate

661580

-

2.8.2.1

6 entries

2.8.2.15

3'-phosphoadenylylsulfate + genistein = adenosine 3',5'-bisphosphate + ?

645739, 660901

-

2.8.2.2

3'-phosphoadenylyl sulfate + genistein = adenosine 3',5'-bisphosphate + ?

675680

-

2.8.2.2

3'-phosphoadenylylsulfate + genistein = adenosine 3',5'-bisphosphate + ?

645798

-

2.8.2.2

2 entries

2.8.2.28

adenosine 3'-phosphate 5'-phosphosulfate + genistein = adenosine 3',5'-bisphosphate + genistein 7-sulfate

676654

-

2.8.2.4

3'-phosphoadenylylsulfate + genistein = adenosine 3',5'-bisphosphate + genistein 7-sulfate + genistein 4'-sulfate

645905

-

7.6.2.2

ATP + H2O + genistein[side 1] = ADP + phosphate + genistein[side 2]

747619

-

Product in Enzyme-catalyzed Reactions (21 results)

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Show Product (21 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.14.14.87

(2S)-naringenin + O2 + [reduced NADPH-hemoprotein reductase] = genistein + 2 H2O + [oxidized NADPH-hemoprotein reductase]

0

-

3.2.1.108

genistein-7-glucoside + H2O = genistein + D-glucose

0

-

3.2.1.161

genistin + H2O = genistein + beta-D-glucopyranose

0

-

3.2.1.21

genistein 7-beta-D-glucopyranoside + H2O = genistein + D-glucose

0

-

3.2.1.21

genistein 7-O-(6''-O-malonyl-beta-D-glucoside) + H2O = genistein + 6-O-malonyl-beta-D-glucose

0

-

3.2.1.21

genistein 7-O-(6-O-malonyl)beta-D-glucopyranoside + H2O = beta-D-glucose + genistein

0

-

3.2.1.21

genistein 7-O-beta-D-glucoside + H2O = genistein + beta-D-glucose

0

-

3.2.1.21

genistein-7-beta-D-glucopyranoside + H2O = genistein + beta-D-glucose

0

-

3.2.1.21

genistein-7-O-beta-D-glucopyranoside + H2O = genistein + beta-D-glucose

0

-

3.2.1.21

genistein-7-O-beta-D-glucosyl-6''-O-acetate + H2O = genistein + 6-O-acetyl-beta-D-glucose

0

-

3.2.1.21

genistein-7-O-beta-D-glucosyl-6''-O-malonate + H2O = genistein + 6-O-malonyl-beta-D-glucose

0

-

3.2.1.21

genistein-7-O-glucoside + H2O = genistein + beta-D-glucose

0

-

3.2.1.21

genistein-7-O-glucosyl-6''-O-malonate + H2O = genistein + beta-D-glucose-6-O-malonate

0

-

3.2.1.21

genistein-beta-D-glucoside + H2O = genistein + beta-D-glucose

0

-

3.2.1.21

genistin + H2O = beta-D-glucose + genistein

0

-

3.2.1.21

genistin + H2O = genistein + D-glucose

0

-

3.2.1.62

genistein-7-glucopyranoside + H2O = genistein + beta-D-glucose

208743

-

3.2.1.62

genistein-7-glucoside + H2O = genistein + D-glucose

0

-

3.2.1.21

13 entries

3.2.1.62

2 entries

3.2.1.B28

genistin + H2O = beta-D-glucose + genistein

0

-

4.2.1.105

2,5,7,4'-tetrahydroxyisoflavanone = genistein + H2O

0

-

7.6.2.2

ATP + H2O + genistein[side 1] = ADP + phosphate + genistein[side 2]

0

-

Activator in Enzyme-catalyzed Reactions (8 results)

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Show Activating Compound (8 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.11.1.9

-

658933

-

2.3.1.21

-

673451

-

2.3.1.21

activates 3fold alone, and about 6fold in concert with L-carnitine, induces the enzyme expression

673451

-

2.7.1.74

-

671911

-

2.7.1.74

increases activity by increasing phosphorylation of Ser74

672894

-

5.6.1.6

activates prephosphorylated CFTR by binding directly to CFTR, higher concentrations inhibit

210425

-

5.6.1.6

stimulates, potentiation in the presence of forskolin

675622

-

2.3.1.21

2 entries

2.7.1.74

2 entries

5.6.1.6

2 entries

5.6.2.2

0.05 mM, 8fold increase in DNA-cleavage activity for isoform II beta, 5fold increase for isoform II alpha

678286

-

Inhibitor in Enzyme-catalyzed Reactions (89 results)

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Show Inhibitors (89 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.1

inhibition of isoenzyme BB-ADH, no inhibition of isoenzyme AA-ADH and TT-ADH

285650

-

1.1.1.141

-

285939

-

1.1.1.145

-

389390, 684725

-

1.1.1.145

0.00026 mM, 50% inhibition; competitive

656657

-

1.1.1.145

very potent, competitive

762899

-

1.1.1.184

-

685454

-

1.1.1.184

50% inhibition at 0.028 mM

655212

-

1.1.1.184

63% residual activity at 0.05 mM

760865

-

1.1.1.145

3 entries

1.1.1.184

3 entries

1.1.1.252

inhibits by 19%

697274

-

1.1.1.34

isoflavone, isolated and purified from korean soybean paste, structural analysis

655059

-

1.1.1.51

-

740637

-

1.1.1.62

IC50: 0.001 mM

658489

4fj1, 3D-view

1.1.1.62

-

761752

4fj1, 3D-view

1.1.1.62

0.02 mM, about 90% inhibition

668327

4fj1, 3D-view

1.1.1.62

0.05 mM, 59% inhibition

670035

4fj1, 3D-view

1.1.1.62

4 entries

1.10.5.1

-

658434

-

1.11.1.7

-

725143

-

1.11.1.8

-

765855

-

1.11.1.8

inhibits enzyme activity by about 40% at 0.001 and 0.01 mM

725615

-

1.13.11.33

IC50: 0.018 mM

657880

-

1.13.11.33

IC50: 1 mM

657880

-

1.13.11.33

IC50: above 0.167 mM

673767

-

1.11.1.8

2 entries

1.13.11.33

3 entries

1.13.11.34

noncompetitive

684672

-

1.2.3.1

-

726542

-

1.3.1.22

-

725173

-

1.3.1.9

i.e. 4',5,7-trihydroxyisoflavone

711426

-

1.5.1.54

0.5 mM, almost complete inhibition. The inhibition is increased when genistein is preincubated with the enzyme and NADH

760473

-

2.1.1.6

slight inhibition at 0.3 mM

660548

-

2.1.1.6

soy isoflavones at hormonally active concentrations cause a significant reduction of both COMT mRNA levels and COMT activity as well as of the methylation of 4-hydroxyestradiol

685970

-

2.1.1.6

2 entries

2.3.1.41

5,7-dihydroxy-3-(4-hydroxyphenyl)chromen-4-one

736660

-

2.3.1.5

-

677267, 685029

-

2.3.1.85

0.0287 mM

674356

-

2.4.1.17

0.003 mM, 25.4% inhibition. 0.03 mM, 79.5% inhibition; 0.003 mM, 38.8% inhibition. 0.03 mM, 97.6% inhibition; weak; weak

673310

-

2.5.1.18

inhibition of isozymes GST M1-1 and M2-2

673781

-

2.7.1.6

-

704761

-

2.7.10.1

-

660725, 661669, 691886

-

2.7.10.1

broad spectrum PTK inhibitor

660678

-

2.7.10.1

broad-spectrum protein tyrosine kinase inhibitor, 0.03 mM inhibits human ether-a-go-go-related gene channel current and the effect is significantly countered by the protein tyrosine phosphatase inhibitor orthovanadate (1 mM)

691714

-

2.7.10.1

inhibition of epidermal growth factor receptor tyrosine kinase

662841

-

2.7.10.1

protein tyrosine kinase inhibitor

489976

-

2.7.10.2

-

661445, 662555, 663436, 690302

-

2.7.10.2

broad spectrum PTK inhibitor

660678

-

2.7.10.2

broad-spectrum PTK inhibitor, increases volume-sensitive chloride current in atrial myocytes, is antagonized by pretreatment with VO43-

662556

-

2.7.10.2

isoflavone, inhibits PTKs, and reversibly inhibits voltage-dependent transient outward and rectifier inward K+-currents in myocytes, overview

661458

-

2.7.10.2

protein tyrosine kinase inhibitor

489976

-

2.7.10.1

5 entries

2.7.10.2

5 entries

2.7.10.3

0.2 mM, 20% inhibition

763213

-

2.7.11.1

-

719695

5auz, 3D-view

2.7.11.1

-

719695

5av4, 3D-view

2.7.11.1

2 entries

2.7.11.11

partial inhibition

661884

-

2.7.11.21

decreases Plk1 expression

706088

-

2.7.12.1

-

666747

-

2.7.12.1

competitive inhibition versus ATP, uncompetitive inhibition versus histone H1

664012

-

2.7.12.1

inhibits the enzyme and affects Bacillus anthracis cell growth

740700

-

2.7.12.1

protein tyrosine kinase inhibitor

489976

-

2.7.12.1

4 entries

2.7.13.1

-

441642

-

2.7.4.24

rapid inhibition in vivo

662914

-

2.7.7.31

competitive versus the DNA primer and non-competitive versus the dNTP substrate, IC50: 0.0287 mM

661255

-

2.8.2.1

0.01 mM, 19% inhibition, enzyme form SULT1A3; 0.01 mM, 80% inhibition, enzyme form SULT1A1

662515

-

2.8.2.1

antagonizes aminoflavone by inhibiting SULT1A1

672912

-

2.8.2.1

2 entries

2.8.2.15

IC50: 0.0025 mM, competitive

661469

-

2.8.2.4

potent mixed type inhibitor

662514

-

3.1.1.1

-

750021

-

3.1.1.13

-

729673

-

3.1.1.4

inhibits sPLA(2) enzymes of inflammatory exudates in a concentration dependent manner. Increasing the Ca2+ concentration from 2.5 to 15 mM and substrate concentration up to 0.000120 mM does not alter the level of inhibition

708726

-

3.1.1.8

65.7% inhibition at 1 mM

695282

-

3.1.4.17

IC50: 0.0017 mM, PDB2; IC50: 0.0129 mM, PDB3; IC50: 0.0168 mM, PDB1

667545

-

3.1.4.35

IC50: 0.073 mM, PDB5

667545

-

3.1.4.53

IC50: 0.0095 mM, PDE4

667545

-

3.2.1.1

a isoflavone, 0.888 mM, pH 6.0, room temperature, 25.1% maximum inhibition

693546

-

3.2.1.18

-

702681

-

3.2.1.18

-

703555

-

3.2.1.18

2 entries

3.2.1.20

mixed type

681559

-

3.4.14.4

-

753237

-

3.4.15.1

0.003-0.3 mM genistein decreases the angiotensin-converting enzyme activity in blood plasma in a concentration-dependent manner; the isoflavone inhibits ACE in plasma and alters the vascular responses to angiotensin I and bradykinin, overview

697774

-

3.4.23.1

-

755552

-

3.4.24.17

-

707004

-

3.4.24.74

broad spectrum tyrosine kinase inhibitor, significantly inhibits BFT-stimulated interleukin-8 production

668909

-

3.4.24.80

markedly suppresses the VEGF mRNA induction in MT clones without affecting the VEGF expression in control clones

669211

-

4.2.99.18

-

747260

-

4.3.1.24

weak

34357

-

5.3.3.1

IC50: 0.0023 mM

389390

-

5.3.4.1

suppresses binding of proinsulin to PDI, inhibits 66% of PDIs chaperone activity

652289

-

5.5.1.6

i.e. genistein, inhibits isomerization of 4,2',4'-trihydroxychalcone

3727

-

5.6.1.6

bindings of genistein and ATP are competitive

699616

-

5.6.2.2

-

3812, 3870, 691780

-

5.6.2.2

inhibition of enzyme-mediated religation of DNA

678286

-

5.6.2.2

2 entries

7.2.2.13

tyrosine kinase inhibitor, block phosphorylation of alpha-subunit of the Na+,K+-ATPase

675517

-

7.6.2.2

-

749400

-

7.6.2.2

competitive inhibitor of daunorubicin transport

210402

-

7.6.2.2

2 entries

3D Structure of Enzyme-Ligand-Complex (PDB) (25 results)

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Show 3D Structure of Enzyme-Ligand-Complex (PDB) (25 entries)

EC NUMBER

ENZYME 3D STRUCTURE

1.1.1.62

4fj1, 3D-view

2.7.11.1

5auz, 3D-view

2.7.11.1

5av4, 3D-view

2.7.11.1

5auz, 3D-view

2.7.11.1

5av4, 3D-view

2.7.11.1

5auz, 3D-view

2.7.11.1

5av4, 3D-view

2.7.11.1

5auz, 3D-view

2.7.11.1

5av4, 3D-view

2.7.11.1

5auz, 3D-view

2.7.11.1

5av4, 3D-view

2.7.11.1

5auz, 3D-view

2.7.11.1

5av4, 3D-view

2.7.11.1

5auz, 3D-view

2.7.11.1

5av4, 3D-view

2.7.11.1

5auz, 3D-view

2.7.11.1

5av4, 3D-view

2.7.11.1

5auz, 3D-view

2.7.11.1

5av4, 3D-view

2.7.11.1

5auz, 3D-view

2.7.11.1

5av4, 3D-view

2.7.11.1

5auz, 3D-view

2.7.11.1

5av4, 3D-view

2.7.11.1

5auz, 3D-view

2.7.11.1

5av4, 3D-view

2.7.11.1

24 entries

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (27 results)

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Show Turnover Number (27 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

2.4.1.170

0.0004

-

E392A mutant, enzyme assay is run at pH 8.5 at 30°C

674845

2.4.1.170

0.13

-

H15A mutant, enzyme assay is run at pH 8.5 at 30°C

674845

2.4.1.170

0.13

-

pH 8.5, 30°C, recombinant isozyme GmUGT3

736973

2.4.1.170

0.39

-

pH 8.5, 30°C, recombinant isozyme GmUGT3

736973

2.4.1.170

0.41

-

E456A mutant, enzyme assay is run at pH 8.5 at 30°C

674845

2.4.1.170

0.59

-

H359A muant, enzyme assay is run at pH 8.5 at 30°C

674845

2.4.1.170

0.63

-

E376A mutant, enzyme assay is run at pH 8.5 at 30°C

674845

2.4.1.170

0.66

-

D125A mutant, enzyme assay is run at pH 8.5 at 30°C

674845

2.4.1.170

0.74

-

purified enzyme, enzyme assay is run at pH 8.5 at 30°C

674845

2.4.1.170

0.76

-

wild-type, enzyme assay is run at pH 8.5 at 30°C

674845

2.4.1.170

1.1

-

pH 8.0, 30°C

736979

2.4.1.170

1.75

-

pH 8.5, 30°C, recombinant isozyme GmUGT3

736973

2.4.1.170

2

-

H368A mutant, enzyme assay is run at pH 8.5 at 30°C

674845

2.4.1.170

3

-

E392D mutant, enzyme assay is run at pH 8.5 at 30°C

674845

2.4.1.170

4.34

-

pH 8.5, 30°C, recombinant isozyme GmUGT1

736973

2.4.1.170

6.04

-

pH 8.5, 30°C, recombinant isozyme GmUGT3

736973

2.4.1.170

16 entries

2.4.1.384

1.6

-

at pH 7.0 and 30°C

761566

2.4.1.81

0.005

-

isoform UGT73C20, cosubstrate UDP-glucose, pH 7.5, 30°C

757983

2.4.1.81

0.039

-

isoform UGT88E19, cosubstrate UDP-glucose, pH 7.5, 30°C

757983

2.4.1.81

2 entries

2.5.1.80

0.027

-

pH not specified in the publication, 37°C

722044

2.8.2.1

0.0015

-

enzyme form SULT2A1, 4'-sulfate formation

661580

2.8.2.1

0.0062

-

enzyme form SULT2A1, 7-sulfate formation

661580

2.8.2.1

0.013

-

enzyme form SULT1A1, 4'-sulfate formation

661580

2.8.2.1

0.024

-

enzyme form SULT1A3, 4'-sulfate formation

661580

2.8.2.1

0.11

-

enzyme form SULT1A1, 7-sulfate formation

661580

2.8.2.1

0.12

-

enzyme form SULT1E1, 7-sulfate formation

661580

2.8.2.1

0.124

-

enzyme form SULT1E1, 4'-sulfate formation

661580

2.8.2.1

7 entries

K_M Value (31 results)

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Show KM Value (31 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.1.1.155

0.0735

-

pH 7, 25°C

655462

2.1.1.231

0.0735

-

pH 7.0, 25°C

655462

2.4.1.170

0.00031

-

pH 8.5, 30°C, recombinant isozyme GmUGT3

736973

2.4.1.170

0.00077

-

E392D mutant, enzyme assay is run at pH 8.5 at 30°C

674845

2.4.1.170

0.0026

-

E456A mutant, enzyme assay is run at pH 8.5 at 30°C

674845

2.4.1.170

0.0027

-

H359A muant, enzyme assay is run at pH 8.5 at 30°C

674845

2.4.1.170

0.0027

-

wild-type, enzyme assay is run at pH 8.5 at 30°C

674845

2.4.1.170

0.0036

-

purified enzyme, enzyme assay is run at pH 8.5 at 30°C

674845

2.4.1.170

0.0045

-

E376A mutant, enzyme assay is run at pH 8.5 at 30°C

674845

2.4.1.170

0.0049

-

H368A mutant, enzyme assay is run at pH 8.5 at 30°C

674845

2.4.1.170

0.011

-

E392A mutant, enzyme assay is run at pH 8.5 at 30°C

674845

2.4.1.170

0.0129

-

pH 8.5, 30°C, recombinant isozyme GmUGT3

736973

2.4.1.170

0.016

-

H15A mutant, enzyme assay is run at pH 8.5 at 30°C

674845

2.4.1.170

0.017

-

pH 8.5, 30°C, recombinant isozyme GmUGT1

736973

2.4.1.170

0.0204

-

pH 8.0, 30°C

736979

2.4.1.170

0.0237

-

pH 8.5, 30°C, recombinant isozyme GmUGT3

736973

2.4.1.170

0.0267

-

pH 8.5, 30°C, recombinant isozyme GmUGT3

736973

2.4.1.170

0.06

-

D125A mutant, enzyme assay is run at pH 8.5 at 30°C

674845

2.4.1.170

16 entries

2.4.1.384

0.0226

-

at pH 7.0 and 30°C

761566

2.4.1.81

0.33

-

isoform UGT88E19, cosubstrate UDP-glucose, pH 7.5, 30°C

757983

2.4.1.81

0.38

-

isoform UGT73C20, cosubstrate UDP-glucose, pH 7.5, 30°C

757983

2.4.1.81

2 entries

2.5.1.80

0.16

-

pH not specified in the publication, 37°C

722044

2.8.2.1

0.00051

-

enzyme form SULT1A1, 7-sulfate formation

661580

2.8.2.1

0.00052

-

enzyme form SULT1A1, 4'-sulfate formation

661580

2.8.2.1

0.0017

-

pH 7.0, 20°C, recombinant SULT1,3

671776

2.8.2.1

0.00279

-

enzyme form SULT1E1, 7-sulfate formation

661580

2.8.2.1

0.00294

-

enzyme form SULT1E1, 4'-sulfate formation

661580

2.8.2.1

0.025

-

enzyme form SULT2A1, 7-sulfate formation

661580

2.8.2.1

0.0559

-

enzyme form SULT2A1, 4'-sulfate formation

661580

2.8.2.1

0.371

-

enzyme form SULT1A3, 4'-sulfate formation

661580

2.8.2.1

8 entries

2.8.2.2

0.041

-

pH 7.4, 37°C

645798

K_i Value (13 results)

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Show KI Value (13 entries)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.1.1.145

0.00012

-

37°C, pH 7.4

656657

1.1.1.145

0.00012

-

recombinant enzyme

656657

1.1.1.145

2 entries

1.1.1.51

0.00055

-

pH 7.4, 25°C, recombinant enzyme

740637

2.7.1.6

0.0739

-

-

704761

2.7.12.1

0.000017

-

versus ATP, pH 7.5, 30°C, recombinant mutant Y213F

664012

2.7.12.1

0.00002

-

versus ATP, pH 7.5, 30°C, recombinant wild-type enzyme

664012

2.7.12.1

0.000059

-

versus ATP, pH 7.5, 30°C, recombinant mutant Y317F

664012

2.7.12.1

0.000191

-

versus ATP, pH 7.5, 30°C, recombinant mutant Y148F

664012

2.7.12.1

0.000194

-

versus ATP, pH 7.5, 30°C, recombinant mutant Y297F

664012

2.7.12.1

0.000426

-

versus histone H1, pH 7.5, 30°C, recombinant wild-type enzyme

664012

2.7.7.31

0.0231

-

versus DNA primer

661255

2.7.7.31

0.0338

-

versus dNTP substrate

661255

2.7.12.1

6 entries

2.7.7.31

2 entries

2.8.2.4

0.0005

-

-

662514

IC₅₀ Value (26 results)

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Show IC50 Value (26 entries)

EC NUMBER

IC50 VALUE

IC50 VALUE MAXIMUM

COMMENTARY

LITERATURE

1.1.1.145

0.0059

-

pH 7.4, 25°C

684725

1.1.1.184

0.0061

-

pH 6.0

685454

1.1.1.51

0.0042

-

pH 7.4, 25°C, recombinant enzyme

740637

1.1.1.62

0.001

-

IC50: 0.001 mM

658489

1.13.11.33

0.018

-

IC50: 0.018 mM

657880

1.13.11.33

0.167

-

IC50: above 0.167 mM

673767

1.13.11.33

1

-

IC50: 1 mM

657880

1.13.11.33

3 entries

1.13.11.34

0.125

-

pH 7.4, 27°C

684672

1.2.3.1

0.00468

-

pH 7.0 and 37°C

726542

1.3.1.22

0.71

-

pH not specified in the publication, temperature not specified in the publication

725173

2.3.1.5

0.045

-

-

685029

2.5.1.18

0.004

0.005

pH 7.4, 30°C, purified recombinant isozymes GST M1-1 and M2-2

673781

2.7.7.31

0.0287

-

competitive versus the DNA primer and non-competitive versus the dNTP substrate, IC50: 0.0287 mM

661255

2.8.2.15

0.0025

-

IC50: 0.0025 mM, competitive

661469

3.1.1.13

0.0209

-

at pH 7.0 and 25°C

729673

3.1.4.17

0.0017

-

IC50: 0.0017 mM, PDB2

667545

3.1.4.17

0.0129

-

IC50: 0.0129 mM, PDB3

667545

3.1.4.17

0.0168

-

IC50: 0.0168 mM, PDB1

667545

3.1.4.17

3 entries

3.1.4.35

0.073

-

IC50: 0.073 mM, PDB5

667545

3.1.4.53

0.0095

-

IC50: 0.0095 mM, PDE4

667545

3.2.1.18

0.23

-

in 50 mM Tris-HCl pH 7.5, at 25°C

702681

3.2.1.18

0.38

-

in 50 mM Tris-HCl pH 7.5, at 25°C

702681

3.2.1.18

2 entries

3.2.1.20

0.007

-

pH 6.8, 30°C

681559

3.4.14.4

0.0366

-

pH 7.4, 37°C

753237

3.4.23.1

0.0981

-

at pH 2.0 and 37°C

755552

5.3.3.1

0.0023

-

IC50: 0.0023 mM

389390

References & Links

Literature References (150)

top print hide

Show Reference (150 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

3727

-

Purification and properties of chalcone isomerase from cell suspension cultures of Phaseolus vulgaris

1982

Dixon, R.A.; Dey, P.M.; Whitehead, I.M.

Biochim. Biophys. Acta

715

25-33

3812

-

DNA topoisomerases

1996

Andersen, A.H.; Bendixen, C.; Westergaard, O.

DNA Replication in eucaryotic cells, Cold Spring Harbor Laboratory Press

-

587-617

3870

-

Structure-function analysis of DNA topoisomerase II inhibitors

1996

Insaf, S.; Danks, M.K.; Witiak, D.T.

Curr. Med. Chem.

3

437-466

34357

16667296

Stress responses in alfalfa (Medicago sativa L.)

1990

Jorrin, J.; Dixon, R.A.

Plant Physiol.

92

447-455

208743

10692580

Dietary flavonoids and isoflavone glycosides are hydrolysed by the lactase site of lactase phlorizin hydrolase

2000

Day, A.J.; Canada, F.J.; Diaz, J.C.; Kroon, P.A.; Mclauchlan, R.; Faulds, C.B.; Plumb, G.W.; Morgan, M.R.A.; Williamson, G.

FEBS Lett.

468

166-170

210402

8909298

ATP-dependent transport of lipophilic cytotoxic drugs by membrane vesicles prepared from MRP-overexpressing HL60/ADR cells

1996

Paul, S.; Breuninger, L.M.; Kruh, G.D.

Biochemistry

35

14003-14011

210425

9843756

Genetic disorders of membrane transport. II. Regulation of CFTR by small molecules including HCO3

1998

Illek, B.; Fischer, H.; Machen, T.E.

Am. J. Physiol.

275

G1221-1226

285318

-

Microsomal isoflavone 2'- and 3'-hydroxylases from chickpea (Cicer arietinum L.) cell suspensions induced for pterocarpan phytoalexin formation

1987

Hinderer, W.; Flentje, U.; Barz, W.

FEBS Lett.

214

101-106

285323

9790908

CYP81E1, a cytochrome P450 cDNA of licorice (Glycyrrhiza echinata L.), encodes isoflavone 2'-hydroxylase

1998

Akashi, T.; Aoki, T.; Ayabe, S.I.

Biochem. Biophys. Res. Commun.

251

67-70

285325

3956488

Enzymic synthesis of isoflavones

1986

Kochs, G.; Grisebach, H.

Eur. J. Biochem.

155

311-318

285650

8730210

Isolation and characterization of three alcohol dehydrogenase isozymes from Syrian golden hamster

1996

Keung, W.M.

Alcohol. Clin. Exp. Res.

20

213-220

285939

11006085

Induction of NAD+-linked 15-hydroxyprostaglandin dehydrogenase expression by androgens in human prostate cancer cells

2000

Tong, M.; Tai, H.H.

Biochem. Biophys. Res. Commun.

276

77-81

389390

10704908

Bovine adrenal 3beta-hydroxysteroid dehydrogenase (E.C. 1.1.1.145)/5-ene-4-ene isomerase (E.C. 5.3.3.1): characterization and its inhibition by isoflavones

1999

Wong, C.K.; Keung, W.M.

J. Steroid Biochem. Mol. Biol.

71

191-202

389479

16667295

Stress responses in alfalfa (Medicago sativa L.). I. Induction of phenylpropanoid biosynthesis and hydrolytic enzymes in elicitor-treated cell suspension cultures

1990

Dalkin, K.; Edwards, R.; Edington, B.; Dixon, R.A.

Plant Physiol.

92

440-446

441443

4452353

Purification and properties of a S-adenosylmethionine: isoflavone 4-O-methyltransferase from cell suspension cultures of Cicer arietinum L

1974

Wengenmayer, H.; Ebel, J.; Grisebach, H.

Eur. J. Biochem.

50

135-143

441446

8951042

Affinity chromatography, substrate/product specificity, and amino acid sequence analysis of an isoflavone O-methyltransferase from alfalfa (Medicago sativa L.)

1996

He, X.Z.; Dixon, R.A.

Arch. Biochem. Biophys.

336

121-129

441447

9484461

Stress responses in alfalfa (Medicago sativa L). XXII. cDNA cloning and characterization of an elicitor-inducible isoflavone 7-O-methyltransferase

1998

He, X.Z.; Reddy, J.T.; Dixon, R.A.

Plant Mol. Biol.

36

43-54

441642

1639791

Genistein inhibits protein histidine kinase

1992

Huang, J.; Nasr, M.; Kim, Y.; Matthews, H.R.

J. Biol. Chem.

267

15511-15515

485542

-

Purification and properties of caffeic acid O-methyltransferase from alfalfa root nodules

1981

Vance, C.P.; Bryan, J.W.

Phytochemistry

20

41-43

488802

6458246

UDP-glucose:isoflavone 7-O-glucosyltransferase from roots of chick pea (Cicer arietinum L.)

1981

Koester, J.; Barz, W.

Arch. Biochem. Biophys.

212

98-104

489976

7855884

Inhibitors of protein kinases and phosphatases

1994

MacKintosh, C.; MacKintosh, R.W.

Trends Biochem. Sci.

19

444-448

645739

11457664

Expression and characterization of the human 3b-hydroxysteroid sulfotransferases (SULT2B1alpha and SULT2B1beta)

2001

Meloche, C.A.; Falany, C.N.

J. Steroid Biochem. Mol. Biol.

77

261-269

645798

15618673

Sulfation of environmental estrogens by cytosolic human sulfotransferases

2002

Nishiyama, T.; Ogura, K.; Nakano, H.; Kaku, T.; Takahashi, E.; Ohkubo, Y.; Sekine, K.; Hiratsuka, A.; Kadota, S.; Watabe, T.

Drug Metab. Pharmacokinet.

17

221-228

645905

11478778

Sulfation of Flavonoids and Other Phenolic Dietary Compounds by the Human Cytosolic Sulfotransferases

2001

Pai, T.G.; Suiko, M.; Sakakibara, Y.; Liu, M.C.

Biochem. Biophys. Res. Commun.

285

1175-1179

652289

11694508

Catalytic activity and chaperone function of human protein-disulfide isomerase are required for the efficient refolding of proinsulin

2002

Winter, J.; Klappa, P.; Freedman, R.B.; Lilie, H.; Rudolph, R.

J. Biol. Chem.

277

310-317

655059

15170109

Isoflavones found in korean soybean paste as 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors

2004

Sung, J.H.; Choi, S.J.; Lee, S.W.; Park, K.H.; Moon, T.W.

Biosci. Biotechnol. Biochem.

68

1051-1058

655212

12604222

Cloning, expression and tissue distribution of a tetrameric form of pig carbonyl reductase

2003

Usami, N.; Ishikura, S.; Abe, H.; Nagano, M.; Uebuchi, M.; Kuniyasu, A.; Otagiri, M.; Nakayama, H.; Imamura, Y.; Hara, A.

Chem. Biol. Interact.

143-144

353-361

655462

12899699

Purification and properties of a new S-adenosyl-L-methionine:flavonoid 4'-O-methyltransferase from carnation (Dianthus caryophyllus L.)

2003

Curir, P.; Lanzotti, V.; Dolci, M.; Dolci, P.; Pasini, C.; Tollin, G.

Eur. J. Biochem.

270

3422-3431

656657

15084349

Flavonoid inhibition of overexpressed human 3beta-hydroxysteroid dehydrogenase type II

2004

Ohno, S.; Matsumoto, N.; Watanabe, M.; Nakajin, S.

J. Steroid Biochem. Mol. Biol.

88

175-182

657880

12628491

Inhibition of 15-lipoxygenases by flavonoids: structure-activity relations and mode of action

2003

Sadik, C.D.; Sies, H.; Schewe, T.

Biochem. Pharmacol.

65

773-781

658434

15733542

Quinone reductase 2 substrate specificity and inhibitgion pharmacology

2005

Boutin, J.A.; Chatelein-Egger, F.; Vella, F.; Delagrange, P.; Ferry, G.

Chem. Biol. Interact.

151

213-228

658489

12570693

Inhibitors of 17beta-hydroxysteroid dehydrogenases

2003

Poirier, D.

Curr. Med. Chem.

10

453-477

658933

12115487

Genistein, a soy isoflavone, induces glutathione peroxidase in the human prostate cancer cell lines LNCaP and PC-3

2002

Suzuki, K.; Koike, H.; Matsui, H.; Ono, Y.; Hasumi, M.; Nakazato, H.; Okugi, H.; Sekine, Y.; Oki, K.; Ito, K.; Yamamoto, T.; Fukabori, Y.; Kurokawa, K.; Yamanaka, H.

Int. J. Cancer

99

846-852

659315

14557274

Differential and special properties of the major human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake

2004

Basu, N.K.; Ciotti, M.; Hwang, M.S.; Kole, L.; Mitra, P.S.; Cho, J.W.; Owens, I.S.

J. Biol. Chem.

279

1429-1441

660097

12943758

Partial purification and characterization of a 2,4,5-trichlorophenol detoxifying O-glucosyltransferase from wheat

2003

Brazier, M.; Cole, D.J.; Edwards, R.

Phytochemistry

64

419-424

660173

14617078

Regiospecific hydroxylation of isoflavones by cytochrome p450 81E enzymes from Medicago truncatula

2003

Liu, C.J.; Huhman, D.; Sumner, L.W.; Dixon, R.A.

Plant J.

36

471-484

660548

15254334

Phytochemicals inhibit catechol-O-methyltransferase activity in cytosolic fractions from healthy human mammary tissues: implications for catechol estrogen-induced DNA damage

2004

van Duursen, M.B.; Sanderson, J.T.; de Jong, P.C.; Kraaij, M.; van den Berg, M.

Toxicol. Sci.

81

316-324

660678

15681694

Antagonistic regulation of swelling-activated Cl- current in rabbit ventricle by Src and EGFR protein tyrosine kinases

2005

Ren, Z.; Baumgarten, C.M.

Am. J. Physiol.

288

H2628-2636

660725

16251305

Inhibitory activities of epidermal growth factor receptor tyrosine kinase-targeted dihydroxyisoflavone and trihydroxydeoxybenzoin derivatives on Sarcocystis neurona, Neospora caninum, and Cryptosporidium parvum development

2005

Gargala, G.; Baishanbo, A.; Favennec, L.; Francois, A.; Ballet, J.J.; Rossignol, J.F.

Antimicrob. Agents Chemother.

49

4628-4634

660901

15781253

Identification of a novel estrogen-sulfating cytosolic SULT from zebrafish: molecular cloning, expression, characterization, and ontogeny study

2005

Yasuda, S.; Liu, C.C.; Takahashi, S.; Suiko, M.; Chen, L.; Snow, R.; Liu, M.C.

Biochem. Biophys. Res. Commun.

330

219-225

661255

16099107

Selective inhibitors of terminal deoxyribonucleotidyltransferase (TdT): baicalin and genistin

2005

Uchiyama, Y.; Tagami, J.; Kamisuki, S.; Kasai, N.; Oshige, M.; Chiku, H.; Ibe, S.; Koiwai, O.; Sugawara, F.; Sakaguchi, K.

Biochim. Biophys. Acta

1725

298-304

661445

12876385

Ligand-independent tyrosine kinase signalling in RTH 149 trout hepatoma cells: comparison among heavy metals and pro-oxidants

2003

Burlando, B.; Magnelli, V.; Panfoli, I.; Berti, E.; Viarengo, A.

Cell. Physiol. Biochem.

13

147-154

661458

14687663

Protein tyrosine kinase-dependent modulation of voltage-dependent potassium channels by genistein in rat cardiac ventricular myocytes

2004

Gao, Z.; Lau, C.P.; Wong, T.M.; Li, G.R.

Cell. Signal.

16

333-341

661469

14726148

Characterization of a zebrafish estrogen-sulfating cytosolic sulfotransferase: inhibitory effects and mechanism of action of phytoestrogens

2004

Ohkimoto, K.; Liu, M.Y.; Suiko, M.; Sakakibara, Y.; Liu, M.C.

Chem. Biol. Interact.

147

1-7

661580

15499189

Regioselective monosulfation and disulfation of the phytoestrogens daidzein and genistein by human liver sulfotransferases

2004

Nakano, H.; Ogura, K.; Takahashi, E.; Harada, T.; Nishiyama, T.; Muro, K.; Hiratsuka, A.; Kadota, S.; Watabe, T.

Drug Metab. Pharmacokinet.

19

216-226

661669

12957147

Calcium influx induced by activation of receptor tyrosine kinases in SV40-transfected human corneal endothelial cells

2003

Mergler, S.; Dannowski, H.; Bednarz, J.; Engelmann, K.; Hartmann, C.; Pleyer, U.

Exp. Eye Res.

77

485-495

661704

16045754

Identification of a novel thyroid hormone-sulfating cytosolic sulfotransferase, SULT1 ST5, from zebrafish

2005

Yasuda, S.; Kumar, A.P.; Liu, M.Y.; Sakakibara, Y.; Suiko, M.; Chen, L.; Liu, M.C.

FEBS J.

272

3828-3837

661884

15544940

cAMP-dependent protein kinase of Manduca sexta phosphorylates but does not activate the fat body triglyceride lipase

2004

Patel, R.; Soulages, J.L.; Wells, M.A.; Arrese, E.L.

Insect Biochem. Mol. Biol.

34

1269-1279

662514

15070945

Phytoestrogens are potent inhibitors of estrogen sulfation: implications for breast cancer risk and treatment

2004

Harris, R.M.; Wood, D.M.; Bottomley, L.; Blagg, S.; Owen, K.; Hughes, P.J.; Waring, R.H.; Kirk, C.J.

J. Clin. Endocrinol. Metab.

89

1779-1787

662515

15531517

Human thyroid phenol sulfotransferase enzymes 1A1 and 1A3: activities in normal and diseased thyroid glands, and inhibition by thyroid hormones and phytoestrogens

2004

Ebmeier, C.C.; Anderson, R.J.

J. Clin. Endocrinol. Metab.

89

5597-5605

662555

14610020

Stretch of beta 1 integrin activates an outwardly rectifying chloride current via FAK and Src in rabbit ventricular myocytes

2003

Browe, D.M.; Baumgarten, C.M.

J. Gen. Physiol.

122

689-702

662556

15024039

Differential effects of tyrosine kinase inhibitors on volume-sensitive chloride current in human atrial myocytes: evidence for dual regulation by Src and EGFR kinases

2004

Du, X.L.; Gao, Z.; Lau, C.P.; Chiu, S.W.; Tse, H.F.; Baumgarten, C.M.; Li, G.R.

J. Gen. Physiol.

123

427-439

662841

15724451

Signal transduction mechanisms involved in cardiac preconditioning: role of Ras-GTPase, Ca2+/calmodulin-dependent protein kinase II and epidermal growth factor receptor

2005

Benter, I.F.; Juggi, J.S.; Khan, I.; Yousif, M.H.M.; Canatan, H.; Akhtar, S.

Mol. Cell. Biochem.

268

175-183

662914

15342793

Protocols for regulation and study of diphosphoinositol polyphosphates

2004

Safrany, S.T.

Mol. Pharmacol.

66

1585-1591

663436

15240896

p38 and Src-ERK1/2 pathways regulate crystalline silica-induced chemokine release in pulmonary epithelial cells

2004

Ovrevik, J.; Lag, M.; Schwarze, P.; Refsnes, M.

Toxicol. Sci.

81

480-490

664012

15379551

Functional characterization of peanut serine/threonine/tyrosine protein kinase: molecular docking and inhibition kinetics with tyrosine kinase inhibitors

2004

Rudrabhatla, P.; Rajasekharan, R.

Biochemistry

43

12123-12132

666747

15870194

Human biliverdin reductase: A member of the insulin receptor substrate family with serine/threonine/tyrosine kinase activity

2005

Lerner-Marmarosh, N.; Shen, J.; Torno, M.D.; Kravets, A.; Hu, Z.; Maines, M.D.

Proc. Natl. Acad. Sci. USA

102

7109-7114

667545

15476679

Inhibitory effects of flavonoids on phosphodiesterase isozymes from guinea pig and their structure-activity relationships

2004

Ko, W.C.; Shih, C.M.; Lai, Y.H.; Chen, J.H.; Huang, H.L.

Biochem. Pharmacol.

68

2087-2094

668327

16458559

17beta-Hydroxysteroid dehydrogenase (17beta-HSD) in scleractinian corals and zooxanthellae

2006

Blomquist, C.H.; Lima, P.H.; Tarrant, A.M.; Atkinson, M.J.; Atkinson, S.

Comp. Biochem. Physiol. B Biochem. Mol. Biol.

143

397-403

668909

15385484

Bacteroides fragilis enterotoxin induces intestinal epithelial cell secretion of interleukin-8 through mitogen-activated protein kinases and a tyrosine kinase-regulated nuclear factor-kappaB pathway

2004

Wu, S.; Powell, J.; Mathioudakis, N.; Kane, S.; Fernandez, E.; Sears, C.L.

Infect. Immun.

72

5832-5839

669211

14729679

Up-regulation of vascular endothelial growth factor-A by active membrane-type 1 matrix metalloproteinase through activation of Src-tyrosine kinases

2004

Sounni, N.E.; Roghi, C.; Chabottaux, V.; Janssen, M.; Munaut, C.; Maquoi, E.; Galvez, B.G.; Gilles, C.; Frankenne, F.; Murphy, G.; Foidart, J.M.; Noel, A.

J. Biol. Chem.

279

13564-13574

670035

15876411

Mammalian lignans and genistein decrease the activities of aromatase and 17beta-hydroxysteroid dehydrogenase in MCF-7 cells

2005

Brooks, J.D.; Thompson, L.U.

J. Steroid Biochem. Mol. Biol.

94

461-467

671776

16962072

Substrate characterisation of a recombinant sulfotransferase SULT1 and mRNA expression in chub (Leuciscus cephalus) tissues

2006

Assem, F.L.; Kirk, C.J.; Chipman, J.K.

Biochem. Biophys. Res. Commun.

349

900-905

671911

15183121

Activation of deoxycytidine kinase by protein kinase inhibitors and okadaic acid in leukemic cells

2003

Smal, C.; Cardoen, S.; Betrand, L.; Delacauw, A.; Ferrant, A.; Van den Berghe, G.; Van den Neste, E.; Bontemps, F.

Biochem. Pharmacol.

69

95-103

672894

17350163

Positive regulation of deoxycytidine kinase activity by phosphorylation of Ser-74 in B-cell chronic lymphocytic leukemia lymphocytes

2007

Smal, C.; Van Den Neste, E.; Maerevoet, M.; Poire, X.; Theate, I.; Bontemps, F.

Cancer Lett.

253

68-73

672912

17018623

Activation of aminoflavone (NSC 686288) by a sulfotransferase is required for the antiproliferative effect of the drug and for induction of histone gamma-H2AX

2006

Meng, L.H.; Shankavaram, U.; Chen, C.; Agama, K.; Fu, H.Q.; Gonzalez, F.J.; Weinstein, J.; Pommier, Y.

Cancer Res.

66

9656-9664

673310

15988124

Identification of human UDP-glucuronosyltransferase isoform(s) responsible for the glucuronidation of 2-(4-chlorophenyl)-5-(2-furyl)-4-oxazoleacetic acid (TA-1801A)

2005

Kaji, H.; Kume, T.

Drug Metab. Pharmacokinet.

20

212-218

673451

16362726

Positive regulation of hepatic carnitine palmitoyl transferase 1A (CPT1A) activities by soy isoflavones and L-carnitine

2006

Shin, E.S.; Cho, S.Y.; Lee, E.H.; Lee, S.J.; Chang, I.S.; Lee, T.R.

Eur. J. Nutr.

45

159-164

673767

16701962

Antioxidant and 15-lipoxygenase inhibitory activity of rotenoids, isoflavones and phenolic glycosides from Sarcolobus globosus

2006

Wangensteen, H.; Miron, A.; Alamgir, M.; Rajia, S.; Samuelsen, A.B.; Malterud, K.E.

Fitoterapia

77

290-295

673781

17046132

The inhibition of human glutathione S-transferases activity by plant polyphenolic compounds ellagic acid and curcumin

2007

Hayeshi, R.; Mutingwende, I.; Mavengere, W.; Masiyanise, V.; Mukanganyama, S.

Food Chem. Toxicol.

45

286-295

674128

16448189

Regiospecific flavonoid 7-O-methylation with Streptomyces avermitilis O-methyltransferase expressed in Escherichia coli

2006

Kim, B.G.; Jung, B.R.; Lee, Y.; Hur, H.G.; Lim, Y.; Ahn, J.H.

J. Agric. Food Chem.

54

823-828

674356

16428296

Structure-activity relationship of polyphenols that inhibit fatty acid synthase

2005

Li, B.H.; Ma, X.F.; Wang, Y.; Tian, W.X.

J. Biochem.

138

679-685

674845

17565994

A UDP-glucose:isoflavone 7-O-glucosyltransferase from the roots of soybean (Glycine max) seedlings: Purification, gene cloning, phylogenetics, and an implication for an alternative strategy of enzyme catalysis

2007

Noguchi, A.; Saito, A.; Homma, Y.; Nakao, M.; Sasaki, N.; Nishino, T.; Takahashi, S.; Nakayama, T.

J. Biol. Chem.

282

23581-23590

675517

15935067

Novel regulation of Na, K-ATPase by Src tyrosine kinases in cortical neurons

2005

Wang Xue, Q.; Yu Shan, P.

J. Neurochem.

93

1515-1523

675622

16081479

Disruption of CFTR chloride channel alters mechanical properties and cAMP-dependent Cl- transport of mouse aortic smooth muscle cells

2005

Robert, R.; Norez, C.; Becq, F.

J. Physiol.

568

483-495

675680

17055258

Human cytosolic sulfotransferase 2B1: isoform expression, tissue specificity and subcellular localization

2006

Falany, C.N.; He, D.; Dumas, N.; Frost, A.R.; Falany, J.L.

J. Steroid Biochem. Mol. Biol.

102

214-221

676552

17001495

Functional analysis of members of the isoflavone and isoflavanone O-methyltransferase enzyme families from the model legume Medicago truncatula

2006

Deavours, B.E.; Liu, C.J.; Naoumkina, M.A.; Tang, Y.; Farag, M.A.; Sumner, L.W.; Noel, J.P.; Dixon, R.A.

Plant Mol. Biol.

62

715-733

676654

17095238

Biochemical and molecular characterization of flavonoid 7-sulfotransferase from Arabidopsis thaliana

2006

Gidda, S.K.; Varin, L.

Plant Physiol. Biochem.

44

628-636

677267

16507510

Inhibitory effects of polyphenolic compounds on human arylamine N-acetyltransferase 1 and 2

2006

Kukongviriyapan, V.; Phromsopha, N.; Tassaneeyakul, W.; Kukongviriyapan, U.; Sripa, B.; Hahnvajanawong, V.; Bhudhisawasdi, V.

Xenobiotica

36

15-28

678286

17458941

Bioflavonoids as poisons of human topoisomerase II alpha and II beta

2007

Bandele, O.J.; Osheroff, N.

Biochemistry

46

6097-6108

681559

16802696

Inhibition of alpha-glucosidase and alpha-amylase by flavonoids

2006

Tadera, K.; Minami, Y.; Takamatsu, K.; Matsuoka, T.

J. Nutr. Sci. Vitaminol.

52

149-153

684672

17391639

Inhibition of lipoxygenase by soy isoflavones: evidence of isoflavones as redox inhibitors

2007

Mahesha, H.G.; Singh, S.A.; Rao, A.G.

Arch. Biochem. Biophys.

461

176-185

684725

18571493

Characterization of human DHRS4: An inducible short-chain dehydrogenase/reductase enzyme with 3beta-hydroxysteroid dehydrogenase activity

2008

Matsunaga, T.; Endo, S.; Maeda, S.; Ishikura, S.; Tajima, K.; Tanaka, N.; Nakamura, K.T.; Imamura, Y.; Hara, A.

Arch. Biochem. Biophys.

477

339-347

685029

18280460

Mouse N-acetyltransferase type 2, the homologue of human N-acetyltransferase type 1

2008

Kawamura, A.; Westwood, I.; Wakefield, L.; Long, H.; Zhang, N.; Walters, K.; Redfield, C.; Sim, E.

Biochem. Pharmacol.

75

1550-1560

685454

17827741

Characterization of an oligomeric carbonyl reductase of dog liver: its identity with peroxisomal tetrameric carbonyl reductase

2007

Endo, S.; Matsunaga, T.; Nagano, M.; Abe, H.; Ishikura, S.; Imamura, Y.; Hara, A.

Biol. Pharm. Bull.

30

1787-1791

685970

18192686

Soy isoflavones decrease the catechol-O-methyltransferase-mediated inactivation of 4-hydroxyestradiol in cultured MCF-7 cells

2008

Lehmann, L.; Jiang, L.; Wagner, J.

Carcinogenesis

29

363-370

688645

17363107

Four glucosyltransferases from rice: cDNA cloning, expression, and characterization

2008

Ko, J.H.; Kim, B.G.; Kim, J.H.; Kim, H.; Lim, C.E.; Lim, J.; Lee, C.; Lim, Y.; Ahn, J.

J. Plant Physiol.

165

435-444

690302

18718176

Protein tyrosine kinase, JNK, and ERK involvement in pseudolaric acid B-induced apoptosis of human breast cancer MCF-7 cells

2008

Yu, J.H.; Wang, H.J.; Li, X.R.; Tashiro, S.; Onodera, S.; Ikejima, T.

Acta Pharmacol. Sin.

29

1069-1076

691714

18617000

Both EGFR kinase and Src-related tyrosine kinases regulate human ether-a-go-go-related gene potassium channels

2008

Zhang, D.Y.; Wang, Y.; Lau, C.P.; Tse, H.F.; Li, G.R.

Cell. Signal.

20

1815-1821

691780

18293940

(-)-Epigallocatechin gallate, a major constituent of green tea, poisons human type II topoisomerases

2008

Bandele, O.J.; Osheroff, N.

Chem. Res. Toxicol.

21

936-943

691886

18287580

Role of protein tyrosine kinase and Erk1/2 activities in the Toll-like receptor 2-induced cellular activation of murine B cells by neisserial porin

2008

MacLeod, H.; Bhasin, N.; Wetzler, L.M.

Clin. Vaccine Immunol.

15

630-637

693546

18507367

Flavonoids for controlling starch digestion: structural requirements for inhibiting human alpha-amylase

2008

Lo Piparo, E.; Scheib, H.; Frei, N.; Williamson, G.; Grigorov, M.; Chou, C.J.

J. Med. Chem.

51

3555-3561

694783

18987879

Cyclic GMP acts as a common regulator for the transcriptional activation of the flavonoid biosynthetic pathway in soybean

2009

Suita, K.; Kiryu, T.; Sawada, M.; Mitsui, M.; Nakagawa, M.; Kanamaru, K.; Yamagata, H.

Planta

229

403-413

695282

18274286

Screening of various phenolic acids and flavonoid derivatives for their anticholinesterase potential

2008

Orhan, I.; Kartal, M.; Tosun, F.; Sener, B.

Z. Naturforsch. C

62

829-832

697274

19010313

Trihydroxynaphthalene reductase of Curvularia lunata--a target for flavonoid action?

2009

Brunskole, M.; Zorko, K.; Kerbler, V.; Martens, S.; Stojan, J.; Gobec, S.; Lanisnik Rizner, T.

Chem. Biol. Interact.

178

259-267

697774

19233159

Isoflavone genistein inhibits the angiotensin-converting enzyme and alters the vascular responses to angiotensin I and bradykinin

2009

Montenegro, M.F.; Pessa, L.R.; Tanus-Santos, J.E.

Eur. J. Pharmacol.

607

173-177

699616

19167254

Molecular modeling of the heterodimer of human CFTRs nucleotide-binding domains using a protein-protein docking approach

2009

Huang, S.Y.; Bolser, D.; Liu, H.Y.; Hwang, T.C.; Zou, X.

J. Mol. Graph. Model.

27

822-828

702681

20097567

Potent inhibitor scaffold against Trypanosoma cruzi trans-sialidase

2010

Arioka, S.; Sakagami, M.; Uematsu, R.; Yamaguchi, H.; Togame, H.; Takemoto, H.; Hinou, H.; Nishimura, S.

Bioorg. Med. Chem.

18

1633-1640

703555

20116898

QSAR study of flavonoids and biflavonoids as influenza H1N1 virus neuraminidase inhibitors

2010

Mercader, A.G.; Pomilio, A.B.

Eur. J. Med. Chem.

45

1724-1730

704761

19433218

Functional studies of rat galactokinase

2009

Chu, X.; Li, N.; Liu, X.; Li, D.

J. Biotechnol.

141

142-146

706088

20107874

Modulating polo-like kinase 1 as a means for cancer chemoprevention

2010

Schmit, T.L.; Ledesma, M.C.; Ahmad, N.

Pharm. Res.

27

989-998

707004

19617894

Inhibition of MMP-3 activity and invasion of the MDA-MB-231 human invasive breast carcinoma cell line by bioflavonoids

2009

Phromnoi, K.; Yodkeeree, S.; Anuchapreeda, S.; Limtrakul, P.

Acta Pharmacol. Sin.

30

1169-1176

708726

19894024

Genistein, a potent inhibitor of secretory phospholipase A2: a new insight in down regulation of inflammation

2010

Dharmappa, K.K.; Mohamed, R.; Shivaprasad, H.V.; Vishwanath, B.S.

Inflammopharmacology

18

25-31

711426

19959361

Novel enoyl-ACP reductase (FabI) potential inhibitors of Escherichia coli from Chinese medicine monomers

2010

Yao, J.; Zhang, Q.; Min, J.; He, J.; Yu, Z.

Bioorg. Med. Chem. Lett.

20

56-59

712526

15961179

Regiospecific methylation of naringenin to ponciretin by soybean O-methyltransferase expressed in Escherichia coli

2005

Kim, D.H.; Kim, B.G.; Lee, Y.; Ryu, J.Y.; Lim, Y.; Hur, H.G.; Ahn, J.H.

J. Biotechnol.

119

155-162

719695

10852877

The archaeon Sulfolobus solfataricus contains a membrane-associated protein kinase activity that preferentially phosphorylates threonine residues in vitro

2000

Lower, B.H.; Bischoff, K.M.; Kennelly, P.J.

J. Bacteriol.

182

3452-3459

721961

100061787

An in silico study of the genes for the isoflavonoid pathway enzymes in soybean reveals novel expressed homologues

2010

Livingstone, J.; Seguin, P.; Strömvik, M.

Can. J. Plant Sci.

90

453-469

722044

23106077

Prenylation of flavonoids by using a dimethylallyltryptophan synthase, 7-DMATS, from Aspergillus fumigatus

2011

Yu, X.; Li, S.M.

ChemBioChem

12

2280-2283

722715

21576242

Molecular characterization of a membrane-bound prenyltransferase specific for isoflavone from Sophora flavescens

2011

Sasaki, K.; Tsurumaru, Y.; Yamamoto, H.; Yazaki, K.

J. Biol. Chem.

286

24125-24134

725143

24049667

Lactoperoxidase: structural insights into the function,ligand binding and inhibition

2013

Sharma, S.; Singh, A.K.; Kaushik, S.; Sinha, M.; Singh, R.P.; Sharma, P.; Sirohi, H.; Kaur, P.; Singh, T.P.

Int. J. Biochem. Mol. Biol.

4

108-128

725173

23265084

Inhibitory effects of isoflavonoids on rat prostate testosterone 5alpha-reductase

2012

Bae, M.; Woo, M.; Kusuma, I.W.; Arung, E.T.; Yang, C.H.; Kim, Y.U.

J. Acupunct. Meridian Stud.

5

319-322

725615

22699773

Changes in thyroid peroxidase activity in response to various chemicals

2012

Song, M.; Kim, Y.J.; Park, Y.K.; Ryu, J.C.

J. Environ. Monit.

14

2121-2126

726542

23282065

Structure-based investigation of rat aldehyde oxidase inhibition by flavonoids

2013

Hamzeh-Mivehroud, M.; Rahmani, S.; Rashidi, M.R.; Hosseinpour Feizi, M.A.; Dastmalchi, S.

Xenobiotica

43

661-670

729673

23601990

Synthesis and biological evaluation of phosphorylated flavonoids as potent and selective inhibitors of cholesterol esterase

2014

Wei, Y.; Peng, A.Y.; Wang, B.; Ma, L.; Peng, G.; Du, Y.; Tang, J.

Eur. J. Med. Chem.

74

751-758

736588

25189810

Glycosylation and subsequent malonylation of isoflavonoids in E. coli: strain development, production and insights into future metabolic perspectives

2014

Koirala, N.; Pandey, R.P.; Thang, D.V.; Jung, H.J.; Sohng, J.K.

J. Ind. Microbiol. Biotechnol.

41

1647-1658

736660

26292066

Docking studies of flavonoid compounds as inhibitors of beta-ketoacyl acyl carrier protein synthase I (Kas I) of Escherichia coli

2015

Sabbagh, G.; Berakdar, N.

J. Mol. Graph. Model.

61

214-223

736973

26019269

Identification of a highly specific isoflavone 7-O-glucosyltransferase in the soybean (Glycine max (L.) Merr.)

2015

Funaki, A.; Waki, T.; Noguchi, A.; Kawai, Y.; Yamashita, S.; Takahashi, S.; Nakayama, T.

Plant Cell Physiol.

56

1512-1520

736979

24700248

Molecular cloning and characterization of an isoflavone 7-O-glucosyltransferase from Pueraria lobata

2014

Li, J.; Li, Z.; Li, C.; Gou, J.; Zhang, Y.

Plant Cell Rep.

33

1173-1185

737080

26010150

Drug-metabolizing activity, protein and gene expression of UDP-glucuronosyltransferases are significantly altered in hepatocellular carcinoma patients

2015

Lu, L.; Zhou, J.; Shi, J.; Peng, X.J.; Qi, X.X.; Wang, Y.; Li, F.Y.; Zhou, F.Y.; Liu, L.; Liu, Z.Q.

PLoS ONE

10

e0127524

740637

26002966

Characterization of hamster NAD+-dependent 3(17)beta-hydroxysteroid dehydrogenase belonging to the aldo-keto reductase 1C subfamily

2015

Endo, S.; Noda, M.; Ikari, A.; Tatematsu, K.; El-Kabbani, O.; Hara, A.; Kitade, Y.; Matsunaga, T.

J. Biochem.

158

425-434

740700

22711536

Unveiling the novel dual specificity protein kinases in Bacillus anthracis

2012

Arora, G.; Sajid, A.; Arulanandh, M.D.; Singhal, A.; Mattoo, A.R.; Pomerantsev, A.P.; Leppla, S.H.; Maiti, S.; Singh, Y.

J. Biol. Chem.

287

26749-26763

745417

24560623

Production of bioactive hydroxyflavones by using monooxygenase from Saccharothrix espanaensis

2014

Lee, H.; Kim, B.; Ahn, J.

J. Biotechnol.

176

11-17

745660

27227796

Reduction of soy isoflavones by use of Escherichia coli whole-cell biocatalyst expressing isoflavone reductase under aerobic conditions

2016

Gao, Y.N.; Hao, Q.H.; Zhang, H.L.; Zhou, B.; Yu, X.M.; Wang, X.L.

Lett. Appl. Microbiol.

63

111-116

746010

-

Functional expression of cytochrome P450 in Escherichia coli An approach to functional analysis of uncharacterized enzymes for flavonoid biosynthesis

2015

Uchida, K.; Akashi, T.; Aoki, T.

Plant Biotechnol.

32

205-213

747260

28161249

Inhibitors of nuclease and redox activity of apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APE1/Ref-1)

2017

Laev, S.S.; Salakhutdinov, N.F.; Lavrik, O.I.

Bioorg. Med. Chem.

25

2531-2544

747619

29022498

ATP-binding cassette exporters structure and mechanism with a focus on P-glycoprotein and MRP1

2017

Arana, M.R.; Altenberg, G.

Curr. Med. Chem.

25

1-17

749400

27155371

Modulation of expression and activity of intestinal multidrug resistance-associated protein 2 by xenobiotics

2016

Tocchetti, G.N.; Rigalli, J.P.; Arana, M.R.; Villanueva, S.S.M.; Mottino, A.D.

Toxicol. Appl. Pharmacol.

303

45-57

750021

29421708

Characterization and structure-activity relationship studies of flavonoids as inhibitors against human carboxylesterase 2

2018

Weng, Z.M.; Ge, G.B.; Dou, T.Y.; Wang, P.; Liu, P.K.; Tian, X.H.; Qiao, N.; Yu, Y.; Zou, L.W.; Zhou, Q.; Zhang, W.D.; Hou, J.

Bioorg. Chem.

77

320-329

753237

27754592

Validation of flavonoids as potential dipeptidyl peptidase III inhibitors Experimental and computational approach

2017

Agic, D.; Brkic, H.; Tomic, S.; Karacic, Z.; Spoljarevic, M.; Lisjak, M.; Beslo, D.; Abramic, M.

Chem. Biol. Drug Des.

89

619-627

755552

26162346

Molecular interactions of flavonoids to pepsin Insights from spectroscopic and molecular docking studies

2015

Zeng, H.J.; Yang, R.; Liang, H.; Qu, L.B.

Spectrochim. Acta A. Mol. Biomol. Spectrosc.

151

576-590

755826

29043664

Substrate scope of O-methyltransferase from Streptomyces peucetius for biosynthesis of diverse natural products methoxides

2018

Parajuli, P.; Pandey, R.P.; Nguyen, T.H.T.; Dhakal, D.; Sohng, J.K.

Appl. Biochem. Biotechnol.

184

1404-1420

755859

32005733

Engineering of cyclodextrin glycosyltransferase reveals pH-regulated mechanism of enhanced long-chain glycosylated sophoricoside specificity

2020

Han, R.; Ni, J.; Zhou, J.; Dong, J.; Xu, G.; Ni, Y.

Appl. Environ. Microbiol.

86

e00004-20

756819

27379141

An alternative pathway for formononetin biosynthesis in Pueraria lobata

2016

Li, J.; Li, C.; Gou, J.; Wang, X.; Fan, R.; Zhang, Y.

Front. Plant Sci.

7

861

757354

28660368

High production of genistein diglucoside derivative using cyclodextrin glycosyltransferase from Paenibacillus macerans

2017

Han, R.; Ge, B.; Jiang, M.; Xu, G.; Dong, J.; Ni, Y.

J. Ind. Microbiol. Biotechnol.

44

1343-1354

757717

28481281

The functional characterization of a site-specific apigenin 4'-O-methyltransferase synthesized by the liverwort species Plagiochasma appendiculatum

2017

Liu, H.; Xu, R.X.; Gao, S.; Cheng, A.X.

Molecules

22

759

757983

28633497

Genome-wide identification and functional characterization of UDP-glucosyltransferase genes involved in flavonoid biosynthesis in Glycine max

2017

Yin, Q.; Shen, G.; Di, S.; Fan, C.; Chang, Z.; Pang, Y.

Plant Cell Physiol.

58

1558-1572

758013

27775193

Draft genome assembly and annotation of Glycyrrhiza uralensis, a medicinal legume

2017

Mochida, K.; Sakurai, T.; Seki, H.; Yoshida, T.; Takahagi, K.; Sawai, S.; Uchiyama, H.; Muranaka, T.; Saito, K.

Plant J.

89

181-194

758337

-

Biosynthesis of natural and non-natural genistein glycosides

2017

Parajuli, P.; Pandey, R.; Huyen Nguyen, T.; Shrestha, B.; Yamaguchi, T.; Sohng, J.

RSC Adv.

7

16217-16231

759388

30821967

Identification and characterization of two new 1-O-acyl-glucose-ester forming glucosyltransferases from Erigeron breviscapus

2019

Yang, Y.; Liu, M.; Zhang, W.; Cao, Y.; Li, C.; Wang, W.

J. Agric. Food Chem.

67

2848-2855

760024

28355308

Structural basis for non-genuine phenolic acceptor substrate specificity of Streptomyces roseochromogenes prenyltransferase CloQ from the ABBA/PT-barrel superfamily

2017

Araya-Cloutier, C.; Martens, B.; Schaftenaar, G.; Leipoldt, F.; Gruppen, H.; Vincken, J.

PLoS ONE

12

e0174665

760473

26253470

Genistein inhibits activities of methylenetetrahydrofolate reductase and lactate dehydrogenase, enzymes which use NADH as a substrate

2015

Grabowski, M.; Banecki, B.; Kadzinski, L.; Jakobkiewicz-Banecka, J.; Kazmierkiewicz, R.; Gabig-Ciminska, M.; Wegrzyn, G.; Wegrzyn, A.; Banecka-Majkutewicz, Z.

Biochem. Biophys. Res. Commun.

465

363-367

760811

24893262

Assessing acceptor substrate promiscuity of YjiC-mediated glycosylation toward flavonoids

2014

Pandey, R.; Gurung, R.; Parajuli, P.; Koirala, N.; Tuoi, L.; Sohng, J.

Carbohydr. Res.

393

26-31

760865

28274719

Kinetic features of carbonyl reductase 1 acting on glutathionylated aldehydes

2017

Moschini, R.; Rotondo, R.; Renzone, G.; Balestri, F.; Cappiello, M.; Scaloni, A.; Mura, U.; Del-Corso, A.

Chem. Biol. Interact.

276

127-132

761005

30143203

Mutational analyses for product specificity of YjiC towards alpha-mangostin mono-glucoside

2018

Kim, T.; Le, T.; Nguyen, H.; Cho, K.; Sohng, J.

Enzyme Microb. Technol.

118

76-82

761552

28286122

Regioselective production of sulfated polyphenols using human cytosolic sulfotransferase-expressing Escherichia coli cells

2017

Shimohira, T.; Kurogi, K.; Hashiguchi, T.; Liu, M.C.; Suiko, M.; Sakakibara, Y.

J. Biosci. Bioeng.

124

84-90

761566

28315700

Exploiting the aglycon promiscuity of glycosyltransferase Bs-YjiC from Bacillus subtilis and its application in synthesis of glycosides

2017

Dai, L.; Li, J.; Yao, P.; Zhu, Y.; Men, Y.; Zeng, Y.; Yang, J.; Sun, Y.

J. Biotechnol.

248

69-76

761752

28259640

Structural basis for inhibition of 17beta-hydroxysteroid dehydrogenases by phytoestrogens The case of fungal 17beta-HSDcl

2017

Cassetta, A.; Stojan, J.; Krastanova, I.; Kristan, K.; Brunskole Svegelj, M.; Lamba, D.; Lanisnik Rizner, T.

J. Steroid Biochem. Mol. Biol.

171

80-93

762899

30826252

Endocrine disruptors of inhibiting testicular 3beta-hydroxysteroid dehydrogenase

2019

Zhang, S.; Mo, J.; Wang, Y.; Ni, C.; Li, X.; Zhu, Q.; Ge, R.S.

Chem. Biol. Interact.

303

90-97

763213

25998248

Functional analysis of conserved motifs in a bacterial tyrosine kinase, BtkB, from Myxococcus xanthus

2015

Kato, T.; Shirakawa, Y.; Takegawa, K.; Kimura, Y.

J. Biochem.

158

385-392

765855

31629072

A rapid assay of human thyroid peroxidase activity

2020

Dong, H.; Godlewska, M.; Wade, M.G.

Toxicol. In Vitro

62

104662