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Ligand 4-aminobenzoic acid ethyl ester Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information Molecular Structure
C9 H1 1 NO2
4-aminobenzoic acid ethyl ester
BLFLLBZGZJTVJG-UHFFFAOYSA-N
4-amino-ethylbenzoate, ethyl 4-aminobenzoate
Roles as Enzyme Ligand
Substrate in Enzyme-catalyzed Reactions (2 results)
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4-aminobenzoic acid ethyl ester + H2O = 4-aminobenzoic acid + ethanol
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ethyl 4-aminobenzoate + H2O = 4-aminobenzoate + ethanol
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Product in Enzyme-catalyzed Reactions (1 result)
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ethyl 4-[(phenylacetyl)amino] benzoate + H2O = phenylacetate + 4-amino-ethylbenzoate
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Inhibitor in Enzyme-catalyzed Reactions (1 result)
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Enzyme Kinetic Parameters
KM Value (2 results)
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0.356
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isoform hCE1, 37°C
1.198
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isoform hCE2, 37°C
IC50 Value (1 result)
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0.001399
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pH 6.5, 41°C, recombinant enzyme
References & Links Literature References (3)
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Substrate specificity of carboxylesterase isozymes and their contribution to hydrolase activity in human liver and small intestine
2006
Imai, T.; Taketani, M.; Shii, M.; Hosokawa, M.; Chiba, K.
Drug Metab. Dispos.
34
1734-1741
Differences in intestinal hydrolytic activities between cynomolgus monkeys and humans evaluation of substrate specificities using recombinant carboxylesterase 2 isozymes
2016
Igawa, Y.; Fujiwara, S.; Ohura, K.; Hirokawa, T.; Nishizawa, Y.; Uehara, S.; Uno, Y.; Imai, T.
Mol. Pharm.
13
3176-3186
Characterization of human S-adenosyl-homocysteine hydrolase in vitro and identification of its potential inhibitors
2017
Hao, W.; Li, Y.; Shan, Q.; Han, T.; Li, W.; He, S.; Zhu, K.; Li, Y.; Tan, X.; Gu, J.
J. Enzyme Inhib. Med. Chem.
32
1209-1215
Links to other databases for 4-aminobenzoic acid ethyl ester
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