We're sorry, but BRENDA doesn't work properly without JavaScript. Please make sure you have JavaScript enabled in your browser settings.
Ligand 4-aminobenzoic acid ethyl ester Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information Molecular Structure
C9 H1 1 NO2
4-aminobenzoic acid ethyl ester
BLFLLBZGZJTVJG-UHFFFAOYSA-N
4-amino-ethylbenzoate, ethyl 4-aminobenzoate
Roles as Enzyme Ligand
Substrate in Enzyme-catalyzed Reactions (2 results)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
4-aminobenzoic acid ethyl ester + H2O = 4-aminobenzoic acid + ethanol
-
ethyl 4-aminobenzoate + H2O = 4-aminobenzoate + ethanol
-
Product in Enzyme-catalyzed Reactions (1 result)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ethyl 4-[(phenylacetyl)amino] benzoate + H2O = phenylacetate + 4-amino-ethylbenzoate
-
-
Inhibitor in Enzyme-catalyzed Reactions (1 result)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Enzyme Kinetic Parameters
KM Value (2 results)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.356
-
isoform hCE1, 37°C
1.198
-
isoform hCE2, 37°C
IC50 Value (1 result)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.001399
-
pH 6.5, 41°C, recombinant enzyme
References & Links Literature References (3)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Substrate specificity of carboxylesterase isozymes and their contribution to hydrolase activity in human liver and small intestine
2006
Imai, T.; Taketani, M.; Shii, M.; Hosokawa, M.; Chiba, K.
Drug Metab. Dispos.
34
1734-1741
Differences in intestinal hydrolytic activities between cynomolgus monkeys and humans evaluation of substrate specificities using recombinant carboxylesterase 2 isozymes
2016
Igawa, Y.; Fujiwara, S.; Ohura, K.; Hirokawa, T.; Nishizawa, Y.; Uehara, S.; Uno, Y.; Imai, T.
Mol. Pharm.
13
3176-3186
Characterization of human S-adenosyl-homocysteine hydrolase in vitro and identification of its potential inhibitors
2017
Hao, W.; Li, Y.; Shan, Q.; Han, T.; Li, W.; He, S.; Zhu, K.; Li, Y.; Tan, X.; Gu, J.
J. Enzyme Inhib. Med. Chem.
32
1209-1215
Links to other databases for 4-aminobenzoic acid ethyl ester
BRENDA home
close all tables 
open all tables
top
