Ligand RhoA

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Basic Ligand Information

Molecular Structure
Picture of RhoA (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C26H43N9O11R2S
RhoA
AFNHHLILYQEHKK-DTWKUNHWSA-N

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
UDP-alpha-D-glucose + RhoA = UDP + D-glucosyl-RhoA
show the reaction diagram
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ATP + RhoA = ADP + phosphorylated RhoA
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RhoA + H2O = ?
show the reaction diagram
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RhoA + H2O = ?
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
NAD+ + RhoA = nicotinamide (ADP-D-ribosyl)-RhoA
show the reaction diagram
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RhoA + NAD+ = Nomega-(ADP-D-ribosyl)-L-asparagine41-RhoA + nicotinamide
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geranylgeranyl diphosphate + RhoA = diphosphate + S-geranylgeranyl-RhoA
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ATP + RhoA = ADP + phosphorylated RhoA
show the reaction diagram
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RhoA + H2O = ?
show the reaction diagram
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RhoA + H2O = ?
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
PLC-epsilon is a direct downstream efector for RhoA. RhA-dependent activation of PLC-epsilon depends on a unique insert within the catalytic core of the phospholipase
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MRDI is induced by RhoA and mediates RhoA-dependent cell invasion
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Inhibitor in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
V14-RhoA, strong binding to the C-terminal catalytic domain, negative regulation
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Enzyme Kinetic Parameters

References & Links

Links to other databases for RhoA

ChEBI
PubChem
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PubChem