Ligand 1-arachidonoyl-lysophosphatidic acid

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Basic Ligand Information

Molecular Structure
Picture of 1-arachidonoyl-lysophosphatidic acid (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C23H39O7P
1-arachidonoyl-lysophosphatidic acid
XBFQFMCUPHZKTI-NZRYSPDRSA-N
Synonyms:
1-arachidonoyl-2-lyso-sn-glycerol 3-phosphate, 1-arachidonoyl-2-lysophosphatidic acid, 1-arachidoyl-sn-glycerol 3-phosphate, AA/Lyso-PA

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
AA/Lyso-PA + O2 = 15-HPETE/lyso-PA + 13-HPETE/lyso-PA + 15-HPETE/lyso-PA + 11-HPETE/lyso-PA + 5-HPETE/lyso-PA
show the reaction diagram
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1-arachidonoyl-2-lyso-sn-glycerol 3-phosphate + H2O = 1-arachidonoyl-sn-glycerol + phosphate
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
arachidoyl-CoA + sn-glycerol 3-phosphate = CoA + 1-arachidoyl-sn-glycerol 3-phosphate
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
32% inhibition
-
Clarification of the structural importance of acyl chain for the inhibitory effect of lysophosphatidic acid on lysoPLD activity. Lysophosphatidic acids with polyunsaturated acyl chains are more potent than those with saturated acyl chains in the inhibition of serum lysoPLD activity
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (1 result)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
250
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pH 7.0, 30°C

KM Value (2 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

References & Links

Links to other databases for 1-arachidonoyl-lysophosphatidic acid

ChEBI
PubChem
ChEBI
PubChem