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• Enzyme Kinetic Parameters
• • k_cat Value (Turnover Number)
  • K_M Value
  • K_i Value
  • IC₅₀ Value
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• • References
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Ligand lysophosphatidylethanolamine

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (12 results)

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Show Substrate (12 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.148

1-Acyl-2-arachidonoyl-glycerophosphocholine + lyso-phosphatidylethanolamine = 1-Acyl-2-lyso-glycerophosphocholine + arachidonoylphosphatidylethanolamine

16278

-

2.3.1.148

1-Acyl-2-arachidonoyl-sn-glycero-3-phosphophoinositol + lyso-phosphatidylethanolamine = 1-Acyl-2-lyso-sn-glycero-3-phosphoinositol + arachidonoylphosphatidylethanolamine

16278

-

2.3.1.148

lyso-Phosphatidylethanolamine + phospholipid = Phosphatidylethanolamine + lyso-phospholipid

16278

-

2.3.1.148

Phosphatidylcholine + lyso-phosphatidylethanolamine = lyso-Phosphatidylcholine + phosphatidylethanolamine

16278

-

2.3.1.148

4 entries

2.3.1.67

acetyl-CoA + lyso-phosphatidylethanolamine = CoA + 2-acetyl-1-acyl-phosphatidylethanolamine

487381

-

2.7.8.1

lysophosphatidylethanolamine + CMP = ?

644354

-

3.1.1.23

lysophosphatidylethanolamine + H2O = fatty acid + glycerophosphoethanolamine

751860

-

3.1.1.26

lysophosphatidylethanolamine + H2O = ?

94293, 94294, 94291

-

3.1.1.5

lysophosphatidylethanolamine + H2O = ?

702426

-

3.1.1.5

lysophosphatidylethanolamine + H2O = fatty acid + glycerylphosphoethanolamine

678790, 94366

-

3.1.1.5

2 entries

3.1.4.39

lysophosphatidyl ethanolamine + H2O = lysophosphatidic acid + ethanolamine

749951

-

7.6.2.1

ATP + H2O + lysophosphatidylethanolamine/out = ADP + phosphate + lysophosphatidylethanolamine/in

696476

-

Product in Enzyme-catalyzed Reactions (10 results)

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Show Product (10 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.148

1-acyl-2-lyso-glycerophosphocholine + arachidonoylphosphatidylethanolamine = 1-acyl-2-arachidonoyl-glycerophosphocholine + lyso-phosphatidylethanolamine

-

-

2.3.1.148

1-palmitoyl-2-lyso-glycerophosphocholine + arachidonoylphosphatidylethanolamine = 1-palmitoyl-2-arachidonoyl-glycerophosphocholine + lyso-phosphatidylethanolamine

-

-

2.3.1.148

2 entries

2.3.1.158

phosphatidylethanolamine + 1,2-diacylglycerol = 2-lysophosphatidylethanolamine + triacylglycerol

-

-

2.3.1.43

phosphatidylethanolamine + cholesterol = cholesteryl ester + lysophosphatidylethanolamine

-

-

3.1.1.32

diacyl-sn-glycero-3-phosphorylethanolamine + H2O = fatty acid + lysophosphatidylethanolamine

-

-

3.1.1.32

phosphatidylethanolamine + H2O = lysophosphatidylethanolamine + a carboxylate

-

-

3.1.1.32

phosphatidylethanolamine + H2O = lysophosphatidylethanolamine + a fatty acid anion

-

-

3.1.1.5

phosphatidylethanolamine + H2O = lysophosphatidylethanolamine + glycerophosphorylethanolamine + a carboxylate

-

-

3.1.1.5

phosphatidylethanolamine + H2O = lysophosphatidylethanolamine + glycerophosphorylethanolamine + a fatty acid

-

-

3.1.1.32

3 entries

3.1.1.5

2 entries

7.6.2.1

ATP + H2O + lysophosphatidylethanolamine/out = ADP + phosphate + lysophosphatidylethanolamine/in

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-

Activator in Enzyme-catalyzed Reactions (7 results)

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Show Activating Compound (7 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.2.5.1

highest stimulating activity among the phospholipid extracted from cell membranes tested, if the phospholipids are added directly to the assay mixtures. When water-soluble micellar preparations are substituted for direct addition of the phospholipid to the assay, all the phosphatides demonstrate higher specific activities for stimulating pyruvate oxidase, and the differences in their stimulating capacity are minimized

288359

-

1.3.3.3

3.4fold activation at 0.5 mg/ml

390964

-

2.7.1.107

activates

640361

-

3.1.2.2

-

171023

-

3.1.2.20

-

171023

-

3.1.4.17

stimulation

135218

-

3.5.1.28

-

171996

-

Inhibitor in Enzyme-catalyzed Reactions (5 results)

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Show Inhibitors (5 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

3.1.2.2

weakly inhibitory

646153

-

3.1.2.20

weakly inhibitory

646153

-

3.1.3.4

-

134894

-

3.1.4.2

50.9% residual activity at 4 mM

750552

-

3.2.1.104

-

208429

-

Enzyme Kinetic Parameters

K_M Value (3 results)

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Show KM Value (3 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

3.1.1.23

0.22

-

pH 8.0, 30°C, AtMAGL4

751860

3.1.1.23

0.24

-

pH 8.0, 30°C, AtMAGL4

751860

3.1.1.23

0.28

-

pH 8.0, 30°C, AtMAGL1

751860

3.1.1.23

3 entries

References & Links

Literature References (22)

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Show Reference (22 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

16278

1641397

The role of transacylases in the metabolism of arachidonate and platelet activating factor

1992

Snyder, F.; Lee, T.C.; Blank, M.L.

Prog. Lipid Res.

31

65-86

94291

-

Purification of a lipolytic acyl-hydrolase from Phaseolus vulgaris leaves by affinity chromatography on palmitolyated gauze and its properties

1979

Matsuda, H.; Tanaka, G.; Morita, K.; Hirayama, O.

Agric. Biol. Chem.

43

563-570

94293

454635

Purification and properties of a lipolytic acyl-hydrolase from potato leaves

1979

Matsuda, H.; Hirayama, O.

Biochim. Biophys. Acta

573

155-165

94294

236765

Purification and properties of a lipid acyl-hydrolase from potato tubers

1975

Hirayama, O.; Matsuda, H.; Takeda, H.; Maenaka, K.; Takatsuka, H.

Biochim. Biophys. Acta

384

127-137

94366

8782402

Purification and some properties of phospholipase B from Schizosaccharomyces pombe

1996

Oishi, H.; Tsuda, S.; Watanabe, Y.; Tamai, Y.

Biosci. Biotechnol. Biochem.

60

1087-1092

134894

1770306

Stimulation and inhibition of the activity of rat liver cytosolic phosphatidate phosphohydrolase by various phospholipids

1991

Humble, E.; Berglund, L.

J. Lipid Res.

32

1869-1873

135218

6329099

Properties of a cyclic nucleotide phosphodiesterase of amphibian oocytes that is activated by calmodulin and calcium, by tryptic proteolysis, and by phospholipids

1984

Orellana, O.; Jedlicki, E.; Allende, C.C.; Allende, J.E.

Arch. Biochem. Biophys.

231

345-354

171023

8105781

Purification, characterization and modulation of a microsomal carboxylesterase in rat liver for the hydrolysis of acyl-CoA

1993

Mukherjee, J.J.; Jay, F.T.; Choy, P.C.

Biochem. J.

295

81-86

171996

2885030

Nature of the interactions involved in the lipid-protein complexes of the Escherichia coli N-acetylmuramoyl-L-alanine amidase

1987

Vanderwinkel, E.; De Vlieghere, M.; Charles, P.; Baptist, V.

Biochim. Biophys. Acta

913

238-244

208429

-

Modulation of activities of steryl glucoside hydrolase and UDPG:sterol glucosyltransferase from Sinapis alba by detergents and lipids

1986

Kalinowska, M.; Wojciechowski, Z.A.

Phytochemistry

25

45-49

288359

4323230

Crystalline pyruvate oxidase from Escherichia coli. II. Activation by phospholipids

1971

Cunningham, C.C.; Hager, L.P.

J. Biol. Chem.

246

1575-1582

390964

7372605

Coproporphyrinogen oxidase. I. Purification, properties, and activation by phospholipids

1980

Yoshinaga, T.; Sano, S.

J. Biol. Chem.

255

4722-4726

487381

3196734

Biosynthesis of paf-acether. XI. Regulation of acetyltransferase by enzyme-substrate imbalance

1988

Ninio, E.; Joly, F.; Bessou, G.

Biochim. Biophys. Acta

963

288-294

640361

6303781

Lipid dependence of diacylglycerol kinase from Escherichia coli

1983

Bohnenberger, E.; Sandermann, H.

Eur. J. Biochem.

132

645-650

644354

2556161

Hamster liver cholinephosphotransferase and ethanolaminephosphotransferase are separate enzymes

1989

O, K.M.; Siow, Y.L.; Choy, P.C.

Biochem. Cell Biol.

67

680-686

646153

3674876

Purification of long-chain acyl-CoA hydrolase from bovine heart microsomes and regulation of activity by lysophospholipids

1987

Sanjanwala, M.; Sun, G.Y.; MacQuarrie, R.A.

Arch. Biochem. Biophys.

258

299-306

678790

16495653

Purification and characterization of phospholipase B from Candida utilis

2006

Fujino, S.; Akiyama, D.; Akaboshi, S.; Fujita, T.; Watanabe, Y.; Tamai, Y.

Biosci. Biotechnol. Biochem.

70

377-386

696476

19268715

The yeast plasma membrane P4-ATPases are major transporters for lysophospholipids

2009

Riekhof, W.R.; Voelker, D.R.

Biochim. Biophys. Acta

179

620-627

702426

19501189

Subcellular localization and lysophospholipase/transacylation activities of human group IVC phospholipase A2 (cPLA2gamma)

2009

Yamashita, A.; Tanaka, K.; Kamata, R.; Kumazawa, T.; Suzuki, N.; Koga, H.; Waku, K.; Sugiura, T.

Biochim. Biophys. Acta

1791

1011-1022

749951

25596343

Glycerophosphodiesterase GDE4 as a novel lysophospholipase D a possible involvement in bioactive N-acylethanolamine biosynthesis

2015

Tsuboi, K.; Okamoto, Y.; Rahman, I.A.; Uyama, T.; Inoue, T.; Tokumura, A.; Ueda, N.

Biochim. Biophys. Acta

1851

537-548

750552

27833852

Molecular cloning, heterologous expression, and enzymatic characterization of lysoplasmalogen-specific phospholipase D from Thermocrispum sp.

2016

Matsumoto, Y.; Kashiwabara, N.; Oyama, T.; Murayama, K.; Matsumoto, H.; Sakasegawa, S.; Sugimori, D.

FEBS Open Bio

6

1113-1130

751860

26932457

Molecular and biochemical characterizations of the monoacylglycerol lipase gene family of Arabidopsis thaliana

2016

Kim, R.J.; Kim, H.J.; Shim, D.; Suh, M.C.

Plant J.

85

758-771

Links to other databases for lysophosphatidylethanolamine

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Show Links (1 entry)

ChEBI

PubChem

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