Ligand lysophosphatidylethanolamine

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Basic Ligand Information

Molecular Structure
Picture of lysophosphatidylethanolamine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C9H19NO7PR
lysophosphatidylethanolamine
JCAIWDXKLCEQEO-ATPOGHATSA-N
Synonyms:
1(or 2)-acyl-sn-glycero-3-phosphoethanolamine, 1-alkyl-2-lyso-sn-glycero-3-phosphoethanolamine, 1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine, 2-lyso-phosphatidylethanolamine, 2-lysophosphatidylethanolamine, L-alpha-lysophosphatidylethanolamine, lyso-phosphatidylethanolamine, lysophosphatidyl ethanolamine

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
acetyl-CoA + lyso-phosphatidylethanolamine = CoA + 2-acetyl-1-acyl-phosphatidylethanolamine
show the reaction diagram
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lysophosphatidylethanolamine + CMP = ?
show the reaction diagram
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lysophosphatidylethanolamine + H2O = fatty acid + glycerophosphoethanolamine
show the reaction diagram
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lysophosphatidylethanolamine + H2O = ?
show the reaction diagram
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lysophosphatidyl ethanolamine + H2O = lysophosphatidic acid + ethanolamine
show the reaction diagram
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ATP + H2O + lysophosphatidylethanolamine/out = ADP + phosphate + lysophosphatidylethanolamine/in
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
phosphatidylethanolamine + 1,2-diacylglycerol = 2-lysophosphatidylethanolamine + triacylglycerol
show the reaction diagram
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phosphatidylethanolamine + cholesterol = cholesteryl ester + lysophosphatidylethanolamine
show the reaction diagram
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ATP + H2O + lysophosphatidylethanolamine/out = ADP + phosphate + lysophosphatidylethanolamine/in
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
highest stimulating activity among the phospholipid extracted from cell membranes tested, if the phospholipids are added directly to the assay mixtures. When water-soluble micellar preparations are substituted for direct addition of the phospholipid to the assay, all the phosphatides demonstrate higher specific activities for stimulating pyruvate oxidase, and the differences in their stimulating capacity are minimized
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3.4fold activation at 0.5 mg/ml
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activates
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stimulation
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Inhibitor in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
weakly inhibitory
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weakly inhibitory
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50.9% residual activity at 4 mM
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Enzyme Kinetic Parameters

KM Value (3 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

References & Links

Links to other databases for lysophosphatidylethanolamine

ChEBI
PubChem
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PubChem