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Ligand 24-methylenecholesterol Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information Molecular Structure
C2 8 H4 6 O
24-methylenecholesterol
INDVLXYUCBVVKW-PXBBAZSNSA-N
24-methylene cholesterol, 24-Methylenedesmosterol
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)
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24-methylenecholesterol + NADPH + H+ = campesterol + NADP+
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Substrate in Enzyme-catalyzed Reactions (4 results)
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24-methylenecholesterol + NADPH + H+ = campesterol + NADP+
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24-methylenecholesterol + NADPH + H+ = dihydrobrassicasterol + NADP+
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24-methylenecholesterol + S-adenosyl-L-methionine = 24-ethylidenecholesterol + S-adenosyl-L-homocysteine
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24-methylene cholesterol + UDP-glucose = UDP + 24-methylene-cholesterol 3-beta-D-glucoside
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Product in Enzyme-catalyzed Reactions (2 results)
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desmosterol + S-adenosyl-L-methionine = 24-methylenedesmosterol + S-adenosyl-L-homocysteine
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desmosterol + S-adenosyl-L-methionine = 24-methylenedesmosterol + S-adenosyl-L-homocysteine
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Enzyme Kinetic Parameters
kcat Value (Turnover Number) (1 result)
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0.38
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for the cytosolic enzyme
KM Value (1 result)
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0.024
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for the cytosolic enzyme
References & Links Literature References (4)
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A sterol methyltransferase from bean rust uredospores Uromyces phaseoli
1976
Lin, H.K.; Knoche, H.W.
Phytochemistry
15
683-687
Purification and physico-kinetic characterization of 3beta-hydroxy specific sterol glucosyltransferase from Withania somnifera (L) and its stress response
2007
Madina, B.R.; Sharma, L.K.; Chaturvedi, P.; Sangwan, R.S.; Tuli, R.
Biochim. Biophys. Acta
1774
392-402
Ajuga DELTA24-sterol reductase catalyzes the direct reductive conversion of 24-methylenecholesterol to campesterol
2016
Tsukagoshi, Y.; Suzuki, H.; Seki, H.; Muranaka, T.; Ohyama, K.; Fujimoto, Y.
J. Biol. Chem.
291
8189-8198
Function and molecular regulation of DWARF1 as a C-24 reductase in brassinosteroid biosynthesis in Arabidopsis
2018
Youn, J.H.; Kim, T.W.; Joo, S.H.; Son, S.H.; Roh, J.; Kim, S.; Kim, T.W.; Kim, S.K.
J. Exp. Bot.
69
1873-1886
Links to other databases for 24-methylenecholesterol