Ligand Luteolin 7-O-glucoside

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Basic Ligand Information

Molecular Structure
Picture of Luteolin 7-O-glucoside (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C21H20O11
Luteolin 7-O-glucoside
PEFNSGRTCBGNAN-QNDFHXLGSA-N
Synonyms:
7-O-beta-D-glucosyl-3',4',5,7-tetrahydroxyflavone, 7-O-beta-D-glucosyl-5,7,3',4'-tetrahydroxyflavone, 7-O-beta-D-glucosyl-luteolin, 7-O-beta-D-glucosylluteolin, cynaroside, luteolin-7-beta-D-glucopyranoside, luteolin-7-beta-glucopyranoside, luteolin-7-beta-glucoside, luteolin-7-glucoside, Luteolin-7-glycoside, luteolin-7-O-beta-D-glucopyranoside, luteolin-7-O-glucoside, luteolin 7-O-beta-D-glucopyranoside, luteolin 7-O-beta-D-glucoside, luteolin glucoside

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
luteolin-7-beta-glucopyranoside + H2O = luteolin + beta-D-glucose
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
Luteolin-7-glycoside + O2 = ?
show the reaction diagram
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S-adenosyl-L-methionine + luteolin 7-O-glucoside = S-adenosyl-L-homocysteine + 3'-methoxyluteolin 7-O-glucoside
show the reaction diagram
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luteolin 7-O-glucoside + malonyl-CoA = CoA + luteolin 7-O-glucoside 6''-O-malonylester
show the reaction diagram
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UDP-L-rhamnose + luteolin 7-O-glucoside = UDP + luteolin 7-O-[beta-L-rhamnosyl-(1-2)-beta-D-glucoside]
show the reaction diagram
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luteolin 7-O-beta-D-glucopyranoside + H2O = luteolin + D-glucose
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (13 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
UDP-alpha-D-glucose + luteolin = UDP + luteolin 7-O-beta-D-glucoside
show the reaction diagram
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UDP-alpha-D-glucose + luteolin = UDP + luteolin 7-O-beta-D-glucoside
show the reaction diagram
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UDP-glucose + luteolin = UDP + luteolin 7-O-beta-D-glucoside
show the reaction diagram
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UDP-glucose + luteolin = UDP + luteolin 3'-O-beta-D-glucoside + luteolin 7-O-beta-D-glucoside + luteolin 7,3'-di-O-beta-D-glucoside
show the reaction diagram
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UDP-alpha-D-glucose + luteolin = UDP + cynaroside
show the reaction diagram
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sucrose + luteolin = D-fructose + luteolin glucoside
show the reaction diagram
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UDP-alpha-D-glucose + luteolin = UDP + luteolin 7-O-beta-D-glucoside
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
noncompetitive, IC50: 0.500 mM
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50% inhibition at 0.01mg/ml
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IC50: 0.0351 mM, PDB2
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IC50 is 0.28 mM
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (4 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
22.7
-
-
0.00022
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recombinant enzyme, pH 7.5, temperature not specified in the publication

KM Value (6 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.147
-
recombinant enzyme, pH 7.5, temperature not specified in the publication

IC50 Value (7 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.5
-
noncompetitive, IC50: 0.500 mM
0.0024
-
pH 7.5, 22°C
0.0351
-
IC50: 0.0351 mM, PDB2
0.28
-
IC50 is 0.28 mM
0.28
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37°C

References & Links

Links to other databases for Luteolin 7-O-glucoside

ChEBI
PubChem
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PubChem