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Ligand (methylthio)acetic acid

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

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Show Natural Product (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.1.1.3

dimethylthetin + L-homocysteine = S-methylthioglycolate + L-methionine

0

-

Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Substrate (1 entry)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.5.3.24

methylthioacetate + 5,6,7,8-tetrahydrofolate + O2 = ?

764129

-

Product in Enzyme-catalyzed Reactions (12 results)

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Show Product (12 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.1.1.3

dimethylsulfonioacetate + DL-homocysteine = (methylsulfanyl)acetate + L-methionine

0

-

2.1.1.3

dimethylthetin + L-homocysteine = S-methylthioglycolate + L-methionine

0, 485244, 485245

-

2.1.1.9

ethanethioic S-acid + S-adenosyl-L-methionine = S-methylethanethioate + S-adenosyl-L-homocysteine

0

-

2.1.1.9

mercaptoacetic acid + S-adenosyl-L-methionine = S-methylmercaptoacetic acid + S-adenosyl-L-homocysteine

0

-

2.1.1.3

2 entries

2.1.1.9

2 entries

3.1.1.1

methanethiol + acetyl-CoA = methanethioacetate + coenzyme A

651608

-

3.1.2.12

fluorescein-3',6'-bis(oxy)methylene bis[(methylsulfanyl)acetate] + H2O = fluorescein-3'-oxymethyl (methylsulfanyl)acetate + (methylsulfanyl)acetate

0

-

3.1.2.6

fluorescein-3',6'-bis(oxy)methylene bis[(methylsulfanyl)acetate] + H2O = fluorescein-3'-oxymethyl (methylsulfanyl)acetate + (methylsulfanyl)acetate

0

-

3.5.1.14

methyl-mercaptoacetyl-DL-alanine + H2O = methylmercaptoacetate + DL-alanine

0

-

3.5.1.14

methylmercaptoacetyl-DL-phenylalanine + H2O = methylmercaptoacetate + DL-phenylalanine

0

-

3.5.5.1

(methylthio)acetonitrile + H2O = (methylthio)acetic acid + NH3

0

-

3.5.5.1

(methylthio)acetonitrile + H2O = 2-(methylthio)acetic acid + NH3

0

-

3.5.1.14

2 entries

3.5.5.1

2 entries

3.5.5.5

methylthioacetonitrile + H2O = methylthioacetic acid + NH3

0

-

Inhibitor in Enzyme-catalyzed Reactions (11 results)

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Show Inhibitors (11 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.5.3.1

-

685219

1el9, 3D-view

1.5.3.1

-

685219

3ad7, 3D-view

1.5.3.1

-

685219

3qss, 3D-view

1.5.3.1

comparison of complexes with wild-type and mutant Y317F

672010

1el9, 3D-view

1.5.3.1

comparison of complexes with wild-type and mutant Y317F

672010

3ad7, 3D-view

1.5.3.1

comparison of complexes with wild-type and mutant Y317F

672010

3qss, 3D-view

1.5.3.1

competitive

685282

1el9, 3D-view

1.5.3.1

competitive

685282

3ad7, 3D-view

1.5.3.1

competitive

685282

3qss, 3D-view

1.5.3.24

-

765019

-

1.5.3.24

competitive inhibition with respect to sarcosine

765018

-

1.5.3.1

9 entries

1.5.3.24

2 entries

3D Structure of Enzyme-Ligand-Complex (PDB) (30 results)

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Show 3D Structure of Enzyme-Ligand-Complex (PDB) (30 entries)

EC NUMBER

ENZYME 3D STRUCTURE

1.5.3.1

1el9, 3D-view

1.5.3.1

3ad7, 3D-view

1.5.3.1

3qss, 3D-view

1.5.3.1

1el9, 3D-view

1.5.3.1

3ad7, 3D-view

1.5.3.1

3qss, 3D-view

1.5.3.1

1el9, 3D-view

1.5.3.1

3ad7, 3D-view

1.5.3.1

3qss, 3D-view

1.5.3.1

1el9, 3D-view

1.5.3.1

3ad7, 3D-view

1.5.3.1

3qss, 3D-view

1.5.3.1

1el9, 3D-view

1.5.3.1

3ad7, 3D-view

1.5.3.1

3qss, 3D-view

1.5.3.1

1el9, 3D-view

1.5.3.1

3ad7, 3D-view

1.5.3.1

3qss, 3D-view

1.5.3.1

1el9, 3D-view

1.5.3.1

3ad7, 3D-view

1.5.3.1

3qss, 3D-view

1.5.3.1

1el9, 3D-view

1.5.3.1

3ad7, 3D-view

1.5.3.1

3qss, 3D-view

1.5.3.1

1el9, 3D-view

1.5.3.1

3ad7, 3D-view

1.5.3.1

3qss, 3D-view

1.5.3.1

1el9, 3D-view

1.5.3.1

3ad7, 3D-view

1.5.3.1

3qss, 3D-view

1.5.3.1

30 entries

Enzyme Kinetic Parameters

K_i Value (1 result)

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Show KI Value (1 entry)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.5.3.24

2.05

-

at pH 8.0 and 25°C

765018

References & Links

Literature References (9)

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Show Reference (9 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

485244

13584318

Thetin-homocysteine transmethylase: some further characteristics of the enzyme from rat liver

1958

Maw, G.A.

Biochem. J.

70

168-173

485245

13315256

Thetin-homocysteine transmethylase: a preliminary manometric study of the enzyme from rat liver

1956

Maw, G.A.

Biochem. J.

63

116-124

651608

12452955

The EstA esterase is responsible for the main capacity of Lactococcus lactis to synthesize short chain fatty acid esters in vitro

2002

Nardi, M.; Fiez-Vandal, C.; Tailliez, P.; Monnet, V.

J. Appl. Microbiol.

93

994-1002

672010

16363800

Ionization of zwitterionic amine substrates bound to monomeric sarcosine oxidase

2005

Zhao, G.; Jorns, M.S.

Biochemistry

44

16866-16874

685219

18251505

Arginine 49 is a bifunctional residue important in catalysis and biosynthesis of monomeric sarcosine oxidase: a context-sensitive model for the electrostatic impact of arginine to lysine mutations

2008

Hassan-Abdallah, A.; Zhao, G.; Chen, Z.W.; Mathews, F.S.; Schuman Jorns, M.

Biochemistry

47

2913-2922

685282

18693755

Identification of the oxygen activation site in monomeric sarcosine oxidase: role of lys265 in catalysis

2008

Zhao, G.; Bruckner, R.C.; Jorns, M.S.

Biochemistry

47

9124-9135

764129

11330998

Organization of the multiple coenzymes and subunits and role of the covalent flavin link in the complex heterotetrameric sarcosine oxidase

2001

Eschenbrenner, M.; Chlumsky, L.J.; Khanna, P.; Strasser, F.; Jorns, M.S.

Biochemistry

40

5352-5367

765018

20675294

Channeling and conformational changes in the heterotetrameric sarcosine oxidase from Corynebacterium sp. U-96

2010

Moriguchi, T.; Ida, K.; Hikima, T.; Ueno, G.; Yamamoto, M.; Suzuki, H.

J. Biochem.

148

491-505

765019

22528666

Deuterium kinetic isotope effects in heterotetrameric sarcosine oxidase from Corynebacterium sp. U-96 the anionic form of the substrate in the enzyme-substrate complex is a reactive species

2012

Saito, M.; Itoh, A.; Suzuki, H.

J. Biochem.

151

633-642

Links to other databases for (methylthio)acetic acid

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ChEBI

PubChem