Ligand GDP-mannose

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Basic Ligand Information

Molecular Structure
Picture of GDP-mannose (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C16H25N5O16P2
GDP-mannose
MVMSCBBUIHUTGJ-GDJBGNAASA-N
Synonyms:
alpha-GDP-mannose, GDP-alpha-D-mannopyranose, GDP-alpha-D-mannose, GDP-D-mannose, GDPmannose
Pathway Source
Pathways


Show all pahtways known for Show all BRENDA pathways known for GDP-mannose

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (65 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
GDPmannose + tRNAAsp-queuosine = GDP + tRNAAsp-O-5''-beta-D-mannosylqueuosine
show the reaction diagram
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GDP-mannose + oligosaccharide acceptor = ?
show the reaction diagram
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GDP-mannose + GlcA-beta-(1->2)-D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphospho-dicis,octatrans-undecaprenol = GDP + D-Man-beta-(1->4)-GlcA-beta-(1->2)-D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphospho-dicis,octatrans-undecaprenol
show the reaction diagram
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GDP-mannose + D-glycerate = 2-O-(alpha-D-mannopyranosyl)-D-glycerate + GDP
show the reaction diagram
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GDP-mannose + 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate = GDP + 2-(2-O-(alpha-D-mannopyranosyl)-alpha-D-glucopyranosyl)-3-phospho-D-glycerate
show the reaction diagram
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GDP-D-mannose + (glucomannan)n = GDP + (glucomannan)n+1
show the reaction diagram
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GDP-alpha-D-mannose + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = GDP + alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
show the reaction diagram
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GDP-alpha-D-mannose + alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = GDP + alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
show the reaction diagram
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GDP-alpha-D-mannose + sordaricin = 2'-O-beta-D-mannosylsordaricin + GDP
show the reaction diagram
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GDP-alpha-D-mannose + a very-long-chain inositol phospho-(2'R)-2'-hydroxyphytoceramide = a very-long-chain mannosylinositol phospho-(2'R)-2'-hydroxyphytoceramide + GDP
show the reaction diagram
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GDP-mannose + heteroglycan = GDP + 1,2(or 1,3)-alpha-D-mannosylheteroglycan
show the reaction diagram
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GDP-alpha-D-mannose + 1,2-di-O-C16/C18:1-(alpha-D-glucopyranosyluronic acid)-(1->3)-glycerol = GDP + 1,2-di-O-C16/C18:1-(alpha-D-mannopyranosyl)-(1->4)-(alpha-D-glucopyranosyluronic acid)-(1->3)-glycerol
show the reaction diagram
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diphosphate + GDP-mannose = GTP + alpha-D-mannose 1-phosphate
show the reaction diagram
GDPmannose + phosphate = GDP + mannose 1-phosphate
show the reaction diagram
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GDPmannose + diphosphate = GTP + D-mannose 1-phosphate
show the reaction diagram
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GDP-mannose + endogenous acceptor molecule = GDP + endogenous acceptor molecule modified
show the reaction diagram
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GDP-mannose + H2O = GMP + D-mannose-1-phosphate
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
GDP + alpha-D-mannose 1-phosphate = phosphate + GDP-mannose
show the reaction diagram
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GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (168 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
GDPmannose + tRNAAsp-queuosine = GDP + tRNAAsp-O-5''-beta-D-mannosylqueuosine
show the reaction diagram
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GDP-mannose + D-fructose 6-phosphate = GDP + beta-D-fructofuranosyl-alpha-D-mannopyranoside 6F-phosphate
show the reaction diagram
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GDP-mannose + GlcA-beta-(1->2)-D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphospho-dicis,octatrans-undecaprenol = GDP + D-Man-beta-(1->4)-GlcA-beta-(1->2)-D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphospho-dicis,octatrans-undecaprenol
show the reaction diagram
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GDP-alpha-D-mannose + Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)(Manalpha(1-6))Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-PP-dolichol = GDP + Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)(Manalpha(1-3)Manalpha(1-6))Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-PP-dolichol
show the reaction diagram
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GDP-mannose + 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate = GDP + 2-(2-O-(alpha-D-mannopyranosyl)-alpha-D-glucopyranosyl)-3-phospho-D-glycerate
show the reaction diagram
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GDP-D-mannose + 2-deoxystreptamine = ?
show the reaction diagram
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GDP-alpha-D-mannopyranose + methyl alpha-D-mannopyrannoside = UDP + ?
show the reaction diagram
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GDP-D-mannose + (glucomannan)n = GDP + (glucomannan)n+1
show the reaction diagram
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GDP-alpha-D-mannose + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = GDP + alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
show the reaction diagram
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GDP-alpha-D-mannose + alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = GDP + alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
show the reaction diagram
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GDP-alpha-D-mannose + sordaricin = 2'-O-beta-D-mannosylsordaricin + GDP
show the reaction diagram
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GDP-alpha-D-mannose + a very-long-chain inositol phospho-(2'R)-2'-hydroxyphytoceramide = a very-long-chain mannosylinositol phospho-(2'R)-2'-hydroxyphytoceramide + GDP
show the reaction diagram
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GDP-alpha-D-mannose + [(1->2)-beta-D-mannosyl]8 = GDP + [(1->2)-beta-D-mannosyl]9
show the reaction diagram
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GDP-alpha-D-mannose + 1,2-di-O-C16/C18:1-(alpha-D-glucopyranosyluronic acid)-(1->3)-glycerol = GDP + 1,2-di-O-C16/C18:1-(alpha-D-mannopyranosyl)-(1->4)-(alpha-D-glucopyranosyluronic acid)-(1->3)-glycerol
show the reaction diagram
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GDPmannose + phosphate = GDP + mannose 1-phosphate
show the reaction diagram
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GDPmannose + diphosphate = GTP + D-mannose 1-phosphate
show the reaction diagram
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GDP-mannose + phosphate = GDP + D-mannose 1-phosphate
show the reaction diagram
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GDP-alpha-D-mannose + phosphate = alpha-D-mannose 1-phosphate + GDP
show the reaction diagram
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GDP-mannose + endogenous acceptor molecule = GDP + endogenous acceptor molecule modified
show the reaction diagram
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GDP-mannose + H2O = ?
show the reaction diagram
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GDP-mannose + H2O = GMP + D-mannose 1-phosphate
show the reaction diagram
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GDP-mannose + H2O = ?
show the reaction diagram
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GDP-mannose + H2O = ?
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (16 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
GDP + alpha-D-mannose 1-phosphate = phosphate + GDP-mannose
show the reaction diagram
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GTP + D-mannose 1-phosphate = diphosphate + GDP-mannose
show the reaction diagram
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GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose
show the reaction diagram
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alpha-D-mannose 1-phosphate + GDP = GDP-alpha-D-mannose + phosphate
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
stimulates
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activation, protection
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stimulation
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stimulates by protecting the substrate UDP-GlcNAc from degradation
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Inhibitor in Enzyme-catalyzed Reactions (24 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive inhibitor
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competitive, 85% inhibition
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competitive inhibition of phosphodiesterase activity
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0.2 mM, 17% inhibition; 0.2 mM, 19% inhibition
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3D Structure of Enzyme-Ligand-Complex (PDB) (62 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (49 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
3.9
-
pH 7.5, 30°C, recombinant holoenzyme
1.43
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pH 8.0, 37°C
151
-
pH 6.0, 37°C

KM Value (126 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.032
-
pH 8.0, 37°C
0.018
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pH 7.0, 37°
0.7
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pH 7.6, 95°C
0.00067
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6.2
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pH 8.0, 30°C

Ki Value (13 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.72
-
competitive inhibition
0.29
-
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0.24
-
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IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.008
-
feedback inhibition

References & Links

Links to other databases for GDP-mannose

ChEBI
PubChem
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PubChem