Ligand DELTA1-pyrroline-2-carboxylate

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Basic Ligand Information

Molecular Structure
Picture of DELTA1-pyrroline-2-carboxylate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C5H7NO2
DELTA1-pyrroline-2-carboxylate
RHTAIKJZSXNELN-UHFFFAOYSA-N
Synonyms:
1-pyrroline-2-carboxylate, 1-pyrroline 2-carboxylate, 3,4-dihydro-2H-pyrrole-5-carboxylic acid, DELTA-1-pyrroline-2-carboxylate, DELTA1-pyrrolidine 2-carboxylate, delta1-pyrroline 2-carboxylate


Show all pahtways known for Show all BRENDA pathways known for DELTA1-pyrroline-2-carboxylate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
DELTA1-pyrrolidine 2-carboxylate + NADPH + H+ = L-proline + NADP+
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
cis-3-hydroxy-L-proline = 1-pyrroline-2-carboxylate + H2O
show the reaction diagram
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trans-3-hydroxy-L-proline = 1-pyrroline 2-carboxylate + H2O
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (14 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
DELTA1-pyrrolidine 2-carboxylate + NADPH + H+ = L-proline + NADP+
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (23 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-proline + NADP+ = 1-pyrroline-2-carboxylate + NADPH + H+
show the reaction diagram
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L-proline + NAD+ = DELTA1-pyrroline-2-carboxylate + NADH + H+
show the reaction diagram
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cis-3-hydroxy-L-proline = 1-pyrroline-2-carboxylate + H2O
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (14 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
41.67
-
purified recombinant His-tagged enzyme, with NADPH, pH 7.0, 30°C
6.6
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pH 7.2, 37°C

KM Value (17 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.447
-
purified recombinant His-tagged enzyme, with NADPH, pH 7.0, 30°C
0.045
-
pH 7.2, 37°C

References & Links

Links to other databases for DELTA1-pyrroline-2-carboxylate

ChEBI
PubChem
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PubChem