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Ligand 7-methylguanine Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information Molecular Structure
C6 H7 N5 O
7-methylguanine
FZWGECJQACGGTI-UHFFFAOYSA-N
2-amino-7-methylhypoxanthine, 7-methyl guanine
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
7-methylguanine + alpha-D-ribose 1-phosphate = 7-methylguanosine + phosphate
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In Vivo Product in Enzyme-catalyzed Reactions (5 results)Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
7-methylguanosine + phosphate = 7-methylguanine + alpha-D-ribose 1-phosphate
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alkylated DNA + H2O = 7-methylguanine + ?
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alkylated DNA + H2O = 3-methyladenine + 7-methylguanine + DNA
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alkylated DNA + H2O = 3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
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alkylated DNA + H2O = 7-methyladenine + 7-methylguanine + 3-methyladenine + 3-methylguanine + purine + 6-chloropurine + xanthine + DNA
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Substrate in Enzyme-catalyzed Reactions (1 result)
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7-methylguanine + alpha-D-ribose 1-phosphate = 7-methylguanosine + phosphate
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Product in Enzyme-catalyzed Reactions (17 results)
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7-methylguanosine + phosphate = 7-methylguanine + alpha-D-ribose 1-phosphate
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7-methyl guanosine + H2O = D-ribose + 7-methyl guanine
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7-methylguanosine + H2O = D-ribose + 7-methylguanine
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7-methylguanosine + H2O = 7-methylguanine + D-ribose
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alkylated DNA + H2O = 7-methylguanine + ?
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7-methylguanine residues in alkylated DNA + H2O = 7-methylguanine + DNA
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alkylated DNA + H2O = 3-methyladenine + 3-methylguanine + 7-methyladenine + 7-methylguanine + DNA
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alkylated DNA + H2O = 3-methyladenine + 3-methylguanine + 7-methylguanine + 7-methyladenine + ?
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alkylated DNA + H2O = 3-methyladenine + 7-methylguanine + 3-methylguanine
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alkylated DNA + H2O = 3-methyladenine + 7-methylguanine + 7-methyladenine + DNA
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alkylated DNA + H2O = 3-methyladenine + 7-methylguanine + ?
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alkylated DNA + H2O = 3-methyladenine + 7-methylguanine + DNA
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alkylated DNA + H2O = 3-methyladenine + 7-methylguanine + hypoxanthine + DNA
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alkylated DNA + H2O = 3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + 1,N6-ethenoadenine + hypoxanthine + DNA
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alkylated DNA + H2O = 3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA
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alkylated DNA + H2O = 7-methyladenine + 7-methylguanine + 3-methyladenine + 3-methylguanine + purine + 6-chloropurine + xanthine + DNA
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7-methylguanosine + H2O = 7-methylguanine + D-ribose
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Inhibitor in Enzyme-catalyzed Reactions (5 results)
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0.05 mM, 94% inhibition of exchange between free guanine with guanine
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3D Structure of Enzyme-Ligand-Complex (PDB) (9 results)
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Enzyme Kinetic Parameters
Ki Value (4 results)
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0.082
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25°C, pH 7.0, with 7-methylguanosine as varied substrate
0.001
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pH and temperature not specified in the publication
0.00555
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in 25 mM Tris-HCl, 137 mM NaCl, 2.7 mM KCl, at pH 7.4 and 25°C
References & Links Literature References (6)
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Structure-activity relationships for the binding of ligands to xanthine or guanine phosphoribosyltransferase from Toxoplasma gondii
1995
Naguib, F.N.M.; Iltzsch, M.H.; el Kouni, M.M.; Panzica, R.P.; el Kouni, M.H.
Biochem. Pharmacol.
50
1685-1693
tRNA-guanine transglycosylase from E. coli: a ping-pong kinetic mechanism is consistent with nucleophilic catalysis
2003
Goodenough-Lashua, D.M.; Garcia, G.A.
Bioorg. Chem.
31
331-344
Probing the mechanism of purine nucleoside phosphorylase by steady-state kinetic studies and ligand binding characterization determined by fluorimetric titrations
2006
Wielgus-Kutrowska, B.; Bzowska, A.
Biochim. Biophys. Acta
1764
887-902
Identification of small molecule compounds with higher binding affinity to guanine deaminase (cypin) than guanine
2010
Fernandez, J.R.; Sweet, E.S.; Welsh, W.J.; Firestein, B.L.
Bioorg. Med. Chem.
18
6748-6755
Substrate and inhibitor specificity of tRNA-guanine ribosyltransferase
1984
Farkas, W.; Jacobson, K.; Katze, J.
Biochim. Biophys. Acta
781
64-75
Site-selective ribosylation of fluorescent nucleobase analogs using purine-nucleoside phosphorylase as a catalyst effects of point mutations
2016
Stachelska-Wierzchowska, A.; Wierzchowski, J.; Bzowska, A.; Wielgus-Kutrowska, B.
Molecules
21
44
Links to other databases for 7-methylguanine
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