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Ligand 16alpha-hydroxyprogesterone
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Basic Ligand Information
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open all tablesRoles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)
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EC NUMBER 
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
16alpha-hydroxyprogesterone + UDP-glucuronate = UDP + 16alpha-hydroxyprgesterone-16-O-D-glucuronate
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In Vivo Product in Enzyme-catalyzed Reactions (2 results)
EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2 progesterone + 2 AH2 + 2 O2 = 17alpha-hydroxyprogesterone + 16alpha-hydroxyprogesterone + 2 A + 2 H2O
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progesterone + [reduced NADPH-hemoprotein reductase] + O2 = 17alpha-hydroxyprogesterone + 16alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O
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Substrate in Enzyme-catalyzed Reactions (7 results)
EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
16alpha-hydroxyprogesterone + UDP-glucuronate = UDP + 16alpha-hydroxyprgesterone-16-O-D-glucuronate
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Product in Enzyme-catalyzed Reactions (8 results)
EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
progesterone + [reduced NADPH-hemoprotein reductase] + O2 = 16alpha-hydroxy-progesterone + [oxidized NADPH-hemoprotein reductase] + H2O
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progesterone + [reduced NADPH-hemoprotein reductase] + O2 = 16alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O
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2 progesterone + 2 AH2 + 2 O2 = 17alpha-hydroxyprogesterone + 16alpha-hydroxyprogesterone + 2 A + 2 H2O
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progesterone + [reduced NADPH-hemoprotein reductase] + O2 = 16alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O
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progesterone + [reduced NADPH-hemoprotein reductase] + O2 = 17alpha-hydroxyprogesterone + 16alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O
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progesterone + [reduced NADPH-hemoprotein reductase] + O2 = 16alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O
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progesterone + NADPH + H+ + O2 = 16alpha-hydroxyprogesterone + 2beta,16alpha-dihydroxyprogesterone + NADP+ + H2O
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Inhibitor in Enzyme-catalyzed Reactions (1 result)
Enzyme Kinetic Parameters
KM Value (6 results)
EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
Ki Value (1 result)
References & Links
Literature References (9)
Links to other databases for 16alpha-hydroxyprogesterone
ChEBI
PubChem
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Release 2023.1 (January 2023)
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