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Ligand 2-fluoroadenine

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

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Show Natural Product (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.2.1

9-beta-D-arabinosyl-2-fluoroadenine + phosphate = 2-fluoroadenine + beta-D-arabinose 1-phosphate

0

3gb9, 3D-view

Substrate in Enzyme-catalyzed Reactions (7 results)

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Show Substrate (7 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.2.5

guanosine + 2-fluoroadenine = guanine + 2-fluoroadenosine

759220

-

2.4.2.6

2',3'-dideoxyadenosine + 2-fluoroadenine = 2-fluoro-2',3'-dideoxyadenosine + adenine

759065

-

2.4.2.6

2'-deoxyguanosine + 2-fluoroadenine = 2-fluoro-2'-deoxyadenosine + guanine

759063, 759065

-

2.4.2.6

2-fluoro-2'-deoxyinosine + 2-fluoroadenine = 2-fluoro-2'-deoxyadenosine + 2-fluoroinosine

759065

-

2.4.2.6

9-beta-D-arabinofuranosyl adenine + 2-fluoroadenine = 9-beta-D-arabinofuranosyl 2-fluoroadenine + adenine

759065

-

2.4.2.6

9-beta-D-arabinofuranosyl guanine + 2-fluoroadenine = 9-beta-D-arabinofuranosyl 2-fluoroadenine + guanine

759065

-

2.4.2.6

5 entries

2.4.2.7

2-fluoroadenine + 5-phospho-alpha-D-ribose 1-diphosphate = 2-fluoro-AMP + diphosphate

758925, 759089, 760125

-

Product in Enzyme-catalyzed Reactions (4 results)

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Show Product (4 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.2.1

2-fluoroadenosine + phosphate = 2-fluoroadenine + alpha-D-ribose 1-phosphate

0

3gb9, 3D-view

2.4.2.1

5'-deoxy-5'-iodo-2-fluoroadenosine + phosphate = 2-fluoroadenine + 5-deoxy-5-iodo-alpha-D-ribose 1-phosphate

0

3gb9, 3D-view

2.4.2.1

9-beta-D-arabinosyl-2-fluoroadenine + phosphate = 2-fluoroadenine + beta-D-arabinose 1-phosphate

0

3gb9, 3D-view

2.4.2.1

3 entries

2.4.2.7

2-fluoro-AMP + diphosphate = 2-fluoroadenine + 5-phospho-alpha-D-ribose 1-diphosphate

0

-

3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

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Show 3D Structure of Enzyme-Ligand-Complex (PDB) (1 entry)

EC NUMBER

ENZYME 3D STRUCTURE

2.4.2.1

3gb9, 3D-view

Enzyme Kinetic Parameters

References & Links

Literature References (6)

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Show Reference (6 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

758925

30640018

Structural and functional characterization of thermostable biocatalysts for the synthesis of 6-aminopurine nucleoside-5-monophospate analogues

2019

Arco, J.D.; Perez, E.; Naitow, H.; Matsuura, Y.; Kunishima, N.; Fernandez-Lucas, J.

Biores. Technol.

276

244-252

759063

31264760

Structure-guided tuning of a selectivity switch towards ribonucleosides in Trypanosoma brucei purine nucleoside 2-deoxyribosyltransferase

2019

Del Arco, J.; Mills, A.; Gago, F.; Fernandez-Lucas, J.

ChemBioChem

20

2996-3000

759065

-

Enzymatic synthesis of therapeutic nucleosides using a highly versatile purine nucleoside 2'-deoxyribosyltransferase from Trypanosoma brucei

2018

Perez, E.; Sanchez-Murcia, P.; Jordaan, J.; Blanco, M.; Mancheno, J.; Gago, F.; Fernandez-Lucas, J.

ChemCatChem

10

4406-4416

759089

-

Crystallization and preliminary X-ray diffraction study of recombinant adenine phosphoribosyltransferase from the thermophilic bacterium Thermus thermophilus strain HB27

2017

Sinitsyna, E.; Timofeev, V.; Tuzova, E.; Kostromina, M.; Murav'eva, T.; Esipov, R.; Kuranova, I.

Crystallogr. Rep.

62

580-583

759220

32612982

N-Ribosyltransferase from Archaeoglobus veneficus a novel halotolerant and thermostable biocatalyst for the synthesis of purine ribonucleoside analogs

2020

Acosta, J.; Del Arco, J.; Pisabarro, V.; Gago, F.; Fernandez-Lucas, J.

Front. Bioeng. Biotechnol.

8

593

760125

-

Three-dimensional structure of recombinant adenine phosphoribosyltransferase from thermophilic bacterial strain Thermus thermophilus HB27

2018

Esipov, R.; Timofeev, V.; Sinitsyna, E.; Tuzova, E.; Esipova, L.; Kostromina, M.; Kuranova, I.; Miroshnikov, A.

Russ. J. Bioorg. Chem.

44

504-510

Links to other databases for 2-fluoroadenine

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Show Links (1 entry)

ChEBI

PubChem