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Ligand Manalpha(1-6)Man

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (7 results)

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Show Substrate (7 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.1.101

UDP-N-acetyl-D-glucosamine + Manalpha(1-6)Man = UDP + ?

658192

-

2.4.1.199

beta-mannosylphosphodecaprenol + 1,6-alpha-D-mannobiose = decaprenol phosphate + 1,6-alpha-D-mannosyltriose

638243

-

2.7.8.32

UDP-xylose + 6-O-alpha-D-mannopyranosyl-alpha-D-mannopyranose = UMP + 6-O-(6-O-alpha-D-xylosylphosphono-alpha-D-mannopyranosyl)-alpha-D-mannopyranose

704602

-

3.2.1.24

1,6-alpha-D-mannobiose + H2O = alpha-D-mannose

680469

-

3.2.1.24

Man-alpha(1-6)Man + H2O = alpha-D-mannose

698317

-

3.2.1.24

Manalpha(1-6)Man + H2O = D-mannose

698317

-

3.2.1.24

Manalpha1-6Man + H2O = alpha-mannose

656917

-

3.2.1.24

4 entries

Product in Enzyme-catalyzed Reactions (3 results)

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Show Product (3 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.2.1.152

Man-alpha-(1-6)Man-beta-(1-4)GlcNAc-beta-(1-4)GlcNAc-pyridylamide + H2O = Man-alpha-(1-6)Man + GlcNAc-beta-(1-4)GlcNAc-pyridylamide

0

-

3.2.1.152

Man-alpha-(1-6)Man-beta-(1-4)GlcNAc-beta-(1-4)GlcNAc-pyridylamine + H2O = GlcNAc-beta-(1-4)GlcNAc-pyridylamine + Man-alpha-(1-6)Man

0

-

3.2.1.152

Manalpha(1-6)Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-pyridylaminoside + H2O = Manalpha(1-6)Man + GlcNAcbeta(1-4)GlcNAc-pyridylaminoside

0

-

3.2.1.152

3 entries

Inhibitor in Enzyme-catalyzed Reactions (2 results)

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Show Inhibitors (2 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

3.2.1.114

in decreasing order of efficiency: alpha1,2, alpha 1,3 and alpha1,6-mannosylmannose

646575

-

3.2.1.24

50% inhibition at 100 mM

136002

-

Enzyme Kinetic Parameters

K_M Value (3 results)

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Show KM Value (3 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.4.1.199

35.7

-

-

638243

3.2.1.24

1.455

-

pH 6.5, 50°C

698317

3.2.1.24

1.455

-

pH 6.5, 50°C, 20 min

698317

3.2.1.24

2 entries

K_i Value (1 result)

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Show KI Value (1 entry)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

3.2.1.24

100

-

-

136002

References & Links

Literature References (8)

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Show Reference (8 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

136002

7240229

Purification and characterization of a phospholipid-dependent alpha-mannosidase from rabbit liver

1981

Forsee, W.T.; Schutzbach, J.S.

J. Biol. Chem.

256

6577-6582

638243

2480954

Synthesis of alpha 1-6-mannooligosaccharides in Mycobacterium smegmatis. Function of beta-mannosylphosphoryldecaprenol as the mannosyl donor

1989

Yokoyama, K.; Ballou, C.E.

J. Biol. Chem.

264

21621-21628

646575

4051507

Characterization of microsomal and cytosolic alpha-1,2-mannosidases from mung bean hypocotyls

1985

Forsee, W.T.

Arch. Biochem. Biophys.

242

48-57

656917

11319010

Rice alpha-mannosidase digesting the high mannose glycopeptide of glutelin

2001

Kishimoto, T.; Hori, H.; Takano, D.; Nakano, Y.; Watanabe, M.; Mitsui, T.

Physiol. Plant.

112

15-24

658192

12878032

Are there two forms of beta 2-N-acetylglucosaminyltransferase I in rat testicular and epididymal fluids?

2003

Nozaki, H.; Matsuzawa, T.; Nakamura, T.; Arai, I.; Urashima, T.

Biochim. Biophys. Acta

1649

140-145

680469

17015651

Molecular and biochemical characterization of alpha-glucosidase and alpha-mannosidase and their clustered genes from the thermoacidophilic archaeon Picrophilus torridus

2006

Angelov, A.; Putyrski, M.; Liebl, W.

J. Bacteriol.

188

7123-7131

698317

19038284

Class II alpha-mannosidase from Aspergillus fischeri: energetics of catalysis and inhibition

2009

Shashidhara, K.S.; Gaikwad, S.M.

Int. J. Biol. Macromol.

44

112-115

704602

19864415

A novel xylosylphosphotransferase activity discovered in Cryptococcus neoformans

2009

Reilly, M.C.; Levery, S.B.; Castle, S.A.; Klutts, J.S.; Doering, T.L.

J. Biol. Chem.

284

36118-36127

Links to other databases for Manalpha(1-6)Man

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Show Links (1 entry)

ChEBI

PubChem