Ligand Pyridine 2,5-dicarboxylate

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Basic Ligand Information

Molecular Structure
Picture of Pyridine 2,5-dicarboxylate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C7H5NO4
Pyridine 2,5-dicarboxylate
JXOHGGNKMLTUBP-HSUXUTPPSA-N
Synonyms:
2,5-Dicarboxypyridine, 2,5-Pyridinedicarboxylate, isocinchomeric acid, isocinchomeronic acid, Pyridine-2,5-dicarboxylate, pyridine-2,5-dicarboxylic acid, Pyridine 2,5-dicarboxylic acid

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2,5-Dicarboxypyridine + O2 = ?
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
14% increase of activity at 0.1 mM
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Inhibitor in Enzyme-catalyzed Reactions (20 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
1 mM 3% activity, 0.1 mM 11% activity
-
1 mM, 15% inhibition
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Enzyme Kinetic Parameters

Ki Value (12 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.05
-
pH 7.8, 37°C, Ki-value is determined using soluble extracts of cells expressing enzyme-FLAGHis
0.015
-
competitive inhibition with respect to 2-oxoglutarate and noncompetitive with respect to Fe2+ and the peptide substrate
0.04
-
-
14
-
pH 7.2

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.049
-
pH 7.5, 35°C

References & Links

Links to other databases for Pyridine 2,5-dicarboxylate

ChEBI
PubChem
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PubChem