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BRENDA support

Ligand phosphomevalonate

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Basic Ligand Information

Molecular Structure
Picture of phosphomevalonate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H13O7P
phosphomevalonate
OKZYCXHTTZZYSK-UHFFFAOYSA-M
Synonyms:
(R,S)-5-phosphomevalonate, 5-phosphomevalonate, mevalonate-5-phosphate, mevalonate 5-phosphate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + mevalonate 5-phosphate = ADP + phosphate + isopentenyl phosphate + CO2
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + mevalonate = ADP + phosphomevalonate
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
mevalonate-5-phosphate + H2O = mevalonate + phosphate
show the reaction diagram
-
ATP + mevalonate 5-phosphate = ADP + phosphate + isopentenyl phosphate + CO2
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (14 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ADPbetaS + 5-diphosphomevalonate = ATPbetaS + 5-phosphomevalonate
show the reaction diagram
-

Inhibitor in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
mixed inhibition
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (1 result)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
10.2
-
pH 7.5, 30°C

KM Value (7 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.075
-
pH 7.5, 30°C

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0077
-
pH 7.0, 25°C

References & Links

Links to other databases for phosphomevalonate

ChEBI
PubChem
-
PubChem