Ligand desmosterol

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Basic Ligand Information

Molecular Structure
Picture of desmosterol (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C27H44O
desmosterol
AVSXSVCZWQODGV-DPAQBDIFSA-N
Synonyms:
5alpha-cholesta-5,24-dien-3beta-ol, cholesta-5,24-dien-3beta-ol

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
PROVEN IN VIVO REACTION
ENZYME 3D STRUCTURE
show the reaction diagram
desmosterol + NADP+ = 7-dehydrodesmosterol + NADPH + H+
-

In Vivo Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
PROVEN IN VIVO REACTION
ENZYME 3D STRUCTURE
-
show the reaction diagram
7-dehydrodesmosterol + NADPH = desmosterol + NADP+
-
-
show the reaction diagram
(24R,241R)-fucosterol epoxide = desmosterol + acetaldehyde
-

Substrate in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
REACTION
ENZYME 3D STRUCTURE
show the reaction diagram
desmosterol + O2 = cholesta-5,24-dien-3-one + H2O2
-
show the reaction diagram
desmosterol + NADP+ = 7-dehydrodesmosterol + NADPH + H+
-
show the reaction diagram
desmosterol + S-adenosyl-L-methionine = 24-methylenedesmosterol + S-adenosyl-L-homocysteine
-
show the reaction diagram
oleoyl-CoA + desmosterol = CoA + desmosteryl oleate
-

Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
REACTION
ENZYME 3D STRUCTURE
-
show the reaction diagram
7-dehydrodesmosterol + NADPH = desmosterol + NADP+
-
show the reaction diagram
(24R,241R)-fucosterol epoxide = desmosterol + acetaldehyde
-

Inhibitor in Enzyme-catalyzed Reactions (3 results)

COMMENTARY
EC NUMBER
LITERATURE
ENZYME 3D STRUCTURE
a potent inhibitor of CH25H
-
a potent inhibitor of CH25H; a potent inhibitor of CH25H; a potent inhibitor of CH25H
-
competitive versus sterol and S-adenosyl-L-methionine
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Enzyme Kinetic Parameters

KM Value (8 results)

COMMENTARY
EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
LITERATURE
desmosterol
pH 7.6, 37°C
26.3
-
-
0.063
-
lanosta-7,24-dienol
0.067
-
pH 7.5, 35°C
0.038
-

Ki Value (4 results)

COMMENTARY
EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
LITERATURE
versus S-adenosyl-L-methionine
versus sterol

References & Links

Links to other databases for desmosterol

ChEBI
PubChem
-
PubChem