Ligand melphalan

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Basic Ligand Information

Molecular Structure
Picture of melphalan (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C13H18ClN2O2
melphalan
SGDBTWWWUNNDEQ-UHFFFAOYSA-N
Synonyms:
melphalan[side 1], melphalan[side 2]

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
melphalan + H2O = ?
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
melphalan + H2O = ?
show the reaction diagram
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ATP + H2O + melphalan[side 1] = ADP + phosphate + melphalan[side 2]
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
benzyloxycarbonyl-Gly-L-Pro-melphalan + H2O = benzyloxycarbonyl-Gly-L-Pro + melphalan
show the reaction diagram
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ATP + H2O + melphalan[side 1] = ADP + phosphate + melphalan[side 2]
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
50% inhibition at 0.009 mM, parental 2008 cell, at 0.0088, 2008/C13* cell, at 0.0057 mM, 2008 cell expressing isoform 2
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Enzyme Kinetic Parameters

References & Links

Links to other databases for melphalan

ChEBI
PubChem
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PubChem