Ligand 4-methyltryptamine
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Basic Ligand Information
Molecular Structure

C11H14N2
4-methyltryptamine
QCUCAQZMPVIYAJ-UHFFFAOYSA-N
2-(4-methyl-1H-indol-3-yl)ethanamine
Roles as Enzyme Ligand
Substrate in Enzyme-catalyzed Reactions (3 results)
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4-methyltryptamine + secologanin = 4-methyl-3-alpha(S)-strictosidine + H2O
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4-methyltryptamine + secologanin = ? + H2O
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2-(4-methyl-1H-indol-3-yl)ethanamine + secologanin = (4S,5R,6S)-4-((S)-5-methyl-2,3,4,9-tetrahydro-1H-b-carbolin-1-ylmethyl)-6-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-5-vinyl-5,6-dihydro-4H-pyran-3-carboxylic acid methyl ester + H2O
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Product in Enzyme-catalyzed Reactions (1 result)
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4-methyl-L-tryptophan = 4-methyltryptamine + CO2
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Enzyme Kinetic Parameters
kcat Value (Turnover Number) (1 result)
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HPLC, neutral pH, micromolar to low millimolar substrate concentrations
0.0031
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KM Value (1 result)
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HPLC, neutral pH, micromolar to low millimolar substrate concentrations
0.08
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References & Links
Literature References (4)
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Plant aromatic L-amino acid decarboxylases: evolution, biochemistry, regulation, and metabolic engineering applications
2000
Facchini, P.J.; Huber-Allanach, K.L.; Tari, L.W.
Phytochemistry
54
121-138
Substrate specificity of strictosidine synthase
2006
McCoy, E.; Galan, M.C.; O'Connor S.E.
Bioorg. Med. Chem. Lett.
16
2475-2478
3D-Structure and function of strictosidine synthase - the key enzyme of monoterpenoid indole alkaloid biosynthesis
2008
Stoeckigt, J.; Barleben, L.; Panjikar, S.; Loris, E.A.
Plant Physiol. Biochem.
46
340-355
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Biosynthetic system of camptothecin: An anticancer plant product
2010
Yamazaki, M.; Asano, T.; Yamazaki, Y.; Sirikantaramas, S.; Sudo, H.; Saito, K.
Pure Appl. Chem.
82
213-218
Links to other databases for 4-methyltryptamine