Ligand 5,6,7,8-tetrahydromethanopterin

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Basic Ligand Information

Molecular Structure
Picture of 5,6,7,8-tetrahydromethanopterin (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C30H45N6O16P
5,6,7,8-tetrahydromethanopterin
SCBIBGUJSMHIAI-LHIIQLEZSA-N
Synonyms:
tetrahydromethanopterin


Show all pahtways known for Show all BRENDA pathways known for 5,6,7,8-tetrahydromethanopterin

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
5,6,7,8-tetrahydromethanopterin + oxidized acceptor = 7,8-dihydromethanopterin + reduced acceptor
show the reaction diagram
-
5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M = 5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + H+
show the reaction diagram
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5,6,7,8-tetrahydromethanopterin + formaldehyde = 5,10-methylenetetrahydromethanopterin + H2O
show the reaction diagram
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5,6,7,8-tetrahydromethanopterin + formaldehyde = 5,10-methylenetetrahydromethanopterin + H2O
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
7,8-dihydromethanopterin + NAD(P)H + H+ = 5,6,7,8-tetrahydromethanopterin + NAD(P)+
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
5,6,7,8-tetrahydromethanopterin + oxidized acceptor = 7,8-dihydromethanopterin + reduced acceptor
show the reaction diagram
-
tetrahydromethanopterin + L-Ser = glycine + ?
show the reaction diagram
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CH3-CO-S-CoA + H+ + tetrahydromethanopterin = CH3-tetrahydromethanopterin + CO + HS-CoA
show the reaction diagram
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5,6,7,8-tetrahydromethanopterin + formaldehyde = 5,10-methylenetetrahydromethanopterin + H2O
show the reaction diagram
-
5,6,7,8-tetrahydromethanopterin + formaldehyde = 5,10-methylenetetrahydromethanopterin + H2O
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
7,8-dihydromethanopterin + NAD(P)H + H+ = 5,6,7,8-tetrahydromethanopterin + NAD(P)+
show the reaction diagram
-
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methanofuran + 5-formyl-5,6,7,8-tetrahydromethanopterin = formylmethanofuran + 5,6,7,8-tetrahydromethanopterin
show the reaction diagram
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-

Enzyme Cofactor/Cosubstrate (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
dependent on
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (3 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
3.53
-
pH 7.4, 37°C

KM Value (11 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.88
-
-
0.1
-
pH 7.4, 37°C
1
-
30°C, pH 8.0

References & Links

Links to other databases for 5,6,7,8-tetrahydromethanopterin

ChEBI
PubChem
ChEBI
PubChem