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Ligand 4-methoxybenzoic acid

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Basic Ligand Information

Molecular Structure
Picture of 4-methoxybenzoic acid (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C8H8O3
4-methoxybenzoic acid
ZEYHEAKUIGZSGI-UHFFFAOYSA-N
Synonyms:
4-anisic acid, 4-methoxy-benzoate, 4-Methoxybenzoate, anisate, Anisic acid, p-anisic acid, p-methoxybenzoate, p-methoxybenzoic acid

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
S-adenosyl-L-methionine + 4-methoxybenzoate = methyl 4-methoxybenzoate + S-adenosyl-L-homocysteine
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
4-methoxybenzonitrile + 2 H2O = 4-methoxybenzoic acid + NH3
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (16 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
anisic acid + ? = anisaldehyde + ?
show the reaction diagram
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4-Methoxybenzoate + reduced carbamoyl methyl viologen = 4-Methoxybenzaldehyde + carbamoyl methyl viologen
show the reaction diagram
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S-adenosyl-L-methionine + 4-methoxybenzoate = methyl 4-methoxybenzoate + S-adenosyl-L-homocysteine
show the reaction diagram
-
UDPglucose + anisate = UDP + 1-O-anisoyl-beta-D-glucose
show the reaction diagram
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4-Methoxybenzoate + CoA + ATP = 4-Methoxybenzoyl-CoA + AMP + diphosphate
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (26 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
4-anisaldehyde + O2 = 4-anisic acid + H2O2
show the reaction diagram
-
4-anisaldehyde + O2 = 4-anisic acid + H2O2
show the reaction diagram
4-methoxybenzaldehyde + H2O + O2 = 4-methoxybenzoate + H2O2
show the reaction diagram
-
p-methoxybenzaldehyde + NAD+ + H2O = p-methoxybenzoate + NADH + H+
show the reaction diagram
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4-methoxy-benzaldehyde + NAD+ + H2O = 4-methoxy-benzoate + NADH + H+
show the reaction diagram
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4-methoxybenzaldehyde + NAD+ + H2O = 4-methoxybenzoate + NADH + H+
show the reaction diagram
-
4-methoxybenzaldehyde + NAD+ + H2O = 4-methoxybenzoate + NADH + 2 H+
show the reaction diagram
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4-methoxybenzaldehyde + H2O + NADP+ = 4-methoxybenzoate + NADPH + 2 H+
show the reaction diagram
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4-methoxybenzaldehyde + NAD+ + H2O = 4-methoxybenzoate + NADH + H+
show the reaction diagram
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4-Methoxybenzaldehyde + benzyl viologen = 4-Methoxybenzoate + reduced carbamoyl methyl viologen
show the reaction diagram
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p-anisaldehyde + H2O + benzylviologen = p-anisic acid + reduced benzylviologen
show the reaction diagram
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ethyl 4-methoxybenzoate + H2O = ethanol + 4-methoxybenzoate
show the reaction diagram
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1-O-anisoyl-beta-D-glucose + H2O = anisic acid + glucose
show the reaction diagram
-
4-methoxybenzoyl-CoA + H2O = 4-methoxybenzoate + CoA
show the reaction diagram
-
4-methoxybenzonitrile + 2 H2O = 4-methoxybenzoic acid + NH3
show the reaction diagram
-

Inhibitor in Enzyme-catalyzed Reactions (11 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive
5 mM, 55% loss of activity
-
2.5 mM, 27% inhibition
-

3D Structure of Enzyme-Ligand-Complex (PDB) (55 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (7 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
37.9
-
pH 7.4, 30°C
0.018
-
pH 6.5, 25°C, recombinant enzyme

KM Value (9 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
2.1
-
-
0.1373
-
pH 6.5, 25°C, recombinant enzyme

Ki Value (3 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.018
-
pH 7.4

IC50 Value (2 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE

References & Links

Links to other databases for 4-methoxybenzoic acid

ChEBI
PubChem
ChEBI
PubChem