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Glutathionylspermidine synthetase
1971
Tabor, H.; Tabor, C.W.
Methods Enzymol.
17
815-817
-
Biochemical studies on protein folding chaperones (HSP90 and cyclophilin) and on trypanosomal enzymes (trypanothione and glutathionylspermidine synthetases) (heat shock protein)
1995
Nadeau, K.C.
Diss. Abstr. Int. B
56
3744
Purification of glutathionylspermidine and trypanothione synthetase from Crithidia fasciculata
1992
Smith, K.; Nadeau, K.; Bradley, M.; Walsh, C.; Fairlamb, A.H.
Protein Sci.
1
874-883
Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata
1998
Tetaud, E.; Manai, F.; Barrett, M.P.; Nadeau, K.; Walsh, C.T.; Fairlamb, A.H.
J. Biol. Chem.
273
19383-19390
Characterization of the peptide substrate specificity of glutathionylspermidine synthetase from Crithidia fasciculata
1997
De Craecker, S.; Verbruggen, C.; Rajan, P.; Smith, K.; Haemers, A.; Fairlamb, A.H.
Mol. Biochem. Parasitol.
84
25-32
Aldehyde and phosphinate analogs of glutathione and glutathionylspermidine: potent, selective binding inhibitors of the E. coli bifunctional glutathionylspermidine synthetase/amidase
1997
Lin, C.H.; Chen, S.; Kwon, D.S.; Coward, J.K.; Walsh, C.T.
Chem. Biol.
4
859-866
Design, synthesis, and biochemical evaluation of phosphonate and phosphonamidate analogs of glutathionylspermidine as inhibitors of glutathionylspermidine synthetase/amidase from Escherichia coli
1997
Chen, S.; Lin, C.H.; Kwon, D.S.; Walsh, C.T.; Coward, J.K.
J. Med. Chem.
40
3842-3850
Glutathionylspermidine metabolism in Escherichia coli. Purification, cloning, overproduction, and characterization of a bifunctional glutathionylspermidine synthetase/amidase
1995
Bollinger, J.M.; Kwon, D.S.; Huisman, G.W.; Kolter, R.; Walsh, C.T.
J. Biol. Chem.
270
14031-14041
Biosynthesis of the trypanosomatid metabolite trypanothione: purification and characterization of trypanothione synthetase from Crithidia fasciculata
1990
Henderson, G.B.; Yamaguchi, M.; Novoa, L.; Fairlamb, A.H.; Cerami, A.
Biochemistry
29
3924-3929
Evidence for a glutathionyl-enzyme intermediate in the amidase activity of the bifunctional glutathionylspermidine synthetase/amidase from Escherichia coli
1997
Lin, C.H.; Kwon, D.S.; Bollinger, J.M.; Walsh, C.T.
Biochemistry
36
14930-14938
Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata
2002
Oza, S.L.; Ariyanayagam, M.R.; Fairlamb, A.H.
Biochem. J.
364
679-686
Glutathione-like tripeptides as inhibitors of glutathionylspermidine synthetase. Part 2: Substitution of the glycine part
2002
Amssoms, K.; Oza, S.L.; Augustyns, K.; Yamani, A.; Lambeir, A.M.; Bal, G.; Van der Veken, P.; Fairlamb, A.H.; Haemers, A.
Bioorg. Med. Chem. Lett.
12
2703-2705
-
Detection by HPLC of a trypanothione synthetase activity in vitro from Entamoeba histolytica
1999
Ondarza, R.N.; Hernandez, E.; Iturbe, A.; Hurtado, G.; Tamayo, E.M.
Biotechnol. Appl. Biochem.
30
41-45
A Single Enzyme Catalyses Formation of Trypanothione from Glutathione and Spermidine in Trypanosoma cruzi
2002
Oza, S.L.; Tetaud, E.; Ariyanayagam, M.R.; Warnon, S.S.; Fairlamb, A.H.
J. Biol. Chem.
277
35853-35861
Phenotypic analysis of trypanothione synthetase knockdown in the African trypanosome
2005
Ariyanayagam, M.R.; Oza, S.L.; Guther, M.L.S.; Fairlamb, A.H.
Biochem. J.
391
425-432
Valdiation of Trypanosoma brucei trypanothione synthetase as drug target
2004
Comini, M.A.; Guerrero, S.A.; Haile, S.; Menge, U.; Lunsdorf, H.; Flohe, L.
Free Radic. Biol. Med.
36
1289-1302
Trypanothione synthesis in Crithidia revisited
2005
Comini, M.; Menge, U.; Wissing, J.; Flohe, L.
J. Biol. Chem.
280
6850-6860
Trypanothione biosynthesis in Leishmania major
2005
Oza, S.L.; Shaw, M.P.; Wyllie, S.; Fairlamb, A.H.
Mol. Biochem. Parasitol.
139
107-116
Trypanothione-dependent glyoxalase I in Trypanosoma cruzi
2006
Greig, N.; Wyllie, S.; Vickers, T.J.; Fairlamb, A.H.
Biochem. J.
400
217-223
Specificity of the trypanothione-dependent Leishmania major glyoxalase I: structure and biochemical comparison with the human enzyme
2006
Ariza, A.; Vickers, T.J.; Greig, N.; Armour, K.A.; Dixon, M.J.; Eggleston, I.M.; Fairlamb, A.H.; Bond, C.S.
Mol. Microbiol.
59
1239-1248
Microbial glyoxalase enzymes: metalloenzymes controlling cellular levels of methylglyoxal
2008
Sukdeo, N.; Honek, J.F.
Drug Metabol. Drug Interact.
23
29-50
Protein S-thiolation by Glutathionylspermidine (Gsp): the role of Escherichia coli Gsp synthetase/amidase in redox regulation
2010
Chiang, B.Y.; Chen, T.C.; Pai, C.H.; Chou, C.C.; Chen, H.H.; Ko, T.P.; Hsu, W.H.; Chang, C.Y.; Wu, W.F.; Wang, A.H.; Lin, C.H.
J. Biol. Chem.
285
25345-25353
Structure and mechanism of Escherichia coli glutathionylspermidine amidase belonging to the family of cysteine; histidine-dependent amidohydrolases/peptidases
2011
Pai, C.H.; Wu, H.J.; Lin, C.H.; Wang, A.H.
Protein Sci.
20
557-566
Escherichia coli glutathionylspermidine synthetase/amidase: phylogeny and effect on regulation of gene expression
2013
Chattopadhyay, M.K.; Chen, W.; Tabor, H.
FEMS Microbiol. Lett.
338
132-140
Comparison of the functions of glutathionylspermidine synthetase/amidase from E. coli and its predicted homologues YgiC and YjfC
2012
Sui, L.; Warren, J.C.; Russell, J.P.; Stourman, N.V.
Int. J. Biochem. Mol. Biol.
3
302-312
Dissecting the catalytic mechanism of Trypanosoma brucei trypanothione synthetase by kinetic analysis and computational modeling
2013
Leroux, A.E.; Haanstra, J.R.; Bakker, B.M.; Krauth-Siegel, R.L.
J. Biol. Chem.
288
23751-23764
Molecular dynamics reveal binding mode of glutathionylspermidine by trypanothione synthetase
2013
Koch, O.; Cappel, D.; Nocker, M.; Jaeger, T.; Flohe, L.; Sotriffer, C.A.; Selzer, P.M.
PLoS ONE
8
e56788
Buthionine sulfoximine is a multitarget inhibitor of trypanothione synthesis in Trypanosoma cruzi
2017
Vazquez, C.; Mejia-Tlachi, M.; Gonzalez-Chavez, Z.; Silva, A.; Rodriguez-Zavala, J.S.; Moreno-Sanchez, R.; Saavedra, E.
FEBS Lett.
591
3881-3894
Genetic and chemical analyses reveal that trypanothione synthetase but not glutathionylspermidine synthetase is essential for Leishmania infantum
2014
Sousa, A.F.; Gomes-Alves, A.G.; Benitez, D.; Comini, M.A.; Flohe, L.; Jaeger, T.; Passos, J.; Stuhlmann, F.; Tomas, A.M.; Castro, H.
Free Radic. Biol. Med.
73
229-238
Identification of novel chemical scaffolds inhibiting trypanothione synthetase from pathogenic trypanosomatids
2016
Benitez, D.; Medeiros, A.; Fiestas, L.; Panozzo-Zenere, E.A.; Maiwald, F.; Prousis, K.C.; Roussaki, M.; Calogeropoulou, T.; Detsi, A.; Jaeger, T.; Sarlauskas, J.; Peterlin Masic, L.; Kunick, C.; Labadie, G.R.; Flohe, L.; Comini, M.A.
PLoS Negl. Trop. Dis.
10
e0004617
Stage-dependent expression and up-regulation of trypanothione synthetase in amphotericin B resistant Leishmania donovani
2014
Equbal, A.; Suman, S.S.; Anwar, S.; Singh, K.P.; Zaidi, A.; Sardar, A.H.; Das, P.; Ali, V.
PLoS ONE
9
e97600