Ligand Tetrapolyphosphate

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Basic Ligand Information

Molecular Structure
Picture of Tetrapolyphosphate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
H6O13P4
Tetrapolyphosphate
YDHWWBZFRZWVHO-UHFFFAOYSA-H
Synonyms:
(phosphate)4, poly(P)4, Tetraphosphate, Tetrapolyphosphates

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (14 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(phosphate)4 + D-glucose = (phosphate)3 + D-glucose 6-phosphate
show the reaction diagram
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tetrapolyphosphate + NADH = tripolyphosphate + NADPH
show the reaction diagram
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UDP-glucose + tetrapolyphosphate = uridine-5'-pentaphosphate + D-glucose-1-phosphate
show the reaction diagram
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tetraphosphate + [microsomal membrane protein] = triphosphate + phosphorylated [microsomal membrane protein]
show the reaction diagram
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tetrapolyphosphate + H2O = ?
show the reaction diagram
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tetrapolyphosphate + H2O = ?
show the reaction diagram
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ATP + tetrapolyphosphate = adenosine 5'-pentaphosphate
show the reaction diagram
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4-coumarate + MgATP2- + tetrapolyphosphate = adenosine 5'-pentaphosphate + ?
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Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(phosphate)5 + D-glucose = (phosphate)4 + D-glucose 6-phosphate
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
10 mM, stimulates
-
activation, removes lag-phase in synthesis at low ATP-levels, not phosphate, diphosphate or tripolyphosphate
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Inhibitor in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
inhibits reaction with ATP
-
50% inhibition at 2000fold polymer molar excess over the long-chain polyP substrate
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Metals and Ions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activation, only peptide hydrolysis, in the presence of Mg2+
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (5 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
8.7
-
in 100 mM HEPES, pH 7.3, containing 20 mM MgCl2, at 30°C
2.5
-
pH 7.0, temperature not specified in the publication

KM Value (13 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.5
-
pH 7.0, temperature not specified in the publication

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.18
-
-

References & Links

Links to other databases for Tetrapolyphosphate

ChEBI
PubChem
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PubChem