Ligand malondialdehyde

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Basic Ligand Information

Molecular Structure
Picture of malondialdehyde (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C3H4O2
malondialdehyde
YPXWWSJGANMFFQ-AQAMAIGXSA-O
Synonyms:
1,3-propandione, Malonic aldehyde, malonic dialdehyde

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
malondialdehyde + NAD+ + H2O = ?
show the reaction diagram
-
malondialdehyde + NAD(P)+ + H2O = ? + NAD(P)H + H+
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = 12-L-hydroxy-5,8,10-heptadecaotrienoic acid + malondialdehyde
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (11 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
malondialdehyde + NADPH = ?
show the reaction diagram
-
malondialdehyde + NADPH + H+ = ?
show the reaction diagram
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1,3-propandione + ferricyanide = 3-hydroxypropanal + ferrocyanide
show the reaction diagram
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malondialdehyde + CoA + NAD+ = ?
show the reaction diagram
-
malondialdehyde + NADP+ = ?
show the reaction diagram
-
malonic dialdehyde = methylglyoxal
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Inhibitor in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
at concentration above 0.8 mM substrate inhibition
-
50% inhibition at 37°C, after 1 h at 5 mM, lipid peroxidation product, enzyme becomes susceptible to oxidative damage leading to structural alterations, carbonylation
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3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (2 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
60.1
-
pH 7.0, 37°C
1.19
-
-

KM Value (6 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
1.78
-
pH 7.0, 37°C

References & Links

Links to other databases for malondialdehyde

ChEBI
PubChem
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PubChem