Ligand isobutanol

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Basic Ligand Information

Molecular Structure
Picture of isobutanol (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C4H10O
isobutanol
ZXEKIIBDNHEJCQ-UHFFFAOYSA-N
Synonyms:
2-methyl-1-propanol, 2-methyl-propanol, 2-methylpropan-1-ol, 2-methylpropanol, iso-butanol, isobutyl alcohol


Show all pahtways known for Show all BRENDA pathways known for isobutanol

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (19 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
REACTION
ENZYME 3D STRUCTURE
show the reaction diagram
2-methyl-1-propanol + NAD+ = isobutyraldehyde + NADH
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show the reaction diagram
isobutanol + NAD+ = ?
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show the reaction diagram
2-methyl-propanol + NADPH + H+ = ?
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show the reaction diagram
isobutanol + NAD+ + H2O = ? + NADH
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show the reaction diagram
acetyl-CoA + isobutanol = CoA + isobutyl acetate
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show the reaction diagram
di-N-acetylchitobiose + 2-methyl-1-propanol = ?
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Product in Enzyme-catalyzed Reactions (25 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
REACTION
ENZYME 3D STRUCTURE
-
show the reaction diagram
isobutyraldehyde + NADPH + H+ = isobutanol + NADP+
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show the reaction diagram
isobutane + NADH + H+ + O2 = 2-methyl-1-propanol + NAD+ + H2O
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show the reaction diagram
isobutyl acetate + H2O = isobutanol + acetate
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show the reaction diagram
2-methylpropyl acetate + H2O = 2-methylpropanol + acetate
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show the reaction diagram
isopropyl acetate + H2O = isobutanol + acetate
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show the reaction diagram
isobutyl methylphosphonate + H2O = isobutanol + methylphosphonate
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show the reaction diagram
russian VX + H2O = methyl-phosphonothioic acid S-(2-diethylamino-ethyl) ester + 2-methylpropanol
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Activator in Enzyme-catalyzed Reactions (1 result)

COMMENTARY
EC NUMBER
LITERATURE
ENZYME 3D STRUCTURE
activates
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Inhibitor in Enzyme-catalyzed Reactions (10 results)

COMMENTARY
EC NUMBER
LITERATURE
ENZYME 3D STRUCTURE
5% v/v: 0-50% loss of activity, depending on substrate, enzyme regains activity after removal of alcohol
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about 95% inhibition at 1% (v/v)
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strong inhibition
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (2 results)

COMMENTARY
EC NUMBER
LITERATURE
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
mutant F97W, pH 8.0, 50°C
0.6
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wild-type, pH 8.0, 50°C
0.3
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KM Value (4 results)

COMMENTARY
EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
LITERATURE
mutant F97W, pH 8.0, 50°C
144.8
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wild-type, pH 8.0, 50°C
138.7
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Ki Value (3 results)

COMMENTARY
EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
LITERATURE
pH 7.5, 25°C

IC50 Value (1 result)

COMMENTARY
EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
LITERATURE
IC50: 4% (v/v)
-999
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References & Links

Links to other databases for isobutanol

ChEBI
PubChem
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PubChem