Ligand harmol
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Basic Ligand Information
Molecular Structure
C12H10N2O
harmol
LBBJNGFCXDOYMQ-UHFFFAOYSA-N
Roles as Enzyme Ligand
Substrate in Enzyme-catalyzed Reactions (1 result)
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3'-phosphoadenylylsulfate + harmol = adenosine 3',5'-bisphosphate + harmol sulfate
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Activator in Enzyme-catalyzed Reactions (1 result)
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i.e. 1-methyl-9H-beta-carbolin-7-ol, a natural beta-carboline plant alkaloid, induces caspase-8 activation
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Inhibitor in Enzyme-catalyzed Reactions (1 result)
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identification by HPLC-ESI-mass spectrometry
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Enzyme Kinetic Parameters
References & Links
Literature References (4)
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Enzymatic characterization and interspecies difference of phenol sulfotransferases, ST1A forms
2001
Honma, W.; Kamiyama, Y.; Yoshinari, K.; Sasano, H.; Shimada, M.; Nagata, K.; Yamazoe, Y.
Drug Metab. Dispos.
29
274-281
Enzymatic aspects of the phenol (aryl) sulfotransferases
2001
Duffel, M.W.; Marshall, A.D.; McPhie, P.; Sharma, V.; Jakoby, W.B.
Drug Metab. Rev.
33
369-395
Harmol induces apoptosis by caspase-8 activation independently on Fas/Fas ligand interaction in human lung carcinoma H596 cells
2009
Abe, A.; Yamada, H.
Anticancer Drugs
20
373-381
beta-Carboline alkaloids in Peganum harmala and inhibition of human monoamine oxidase (MAO)
2010
Herraiz, T.; Gonzalez, D.; Ancin-Azpilicueta, C.; Aran, V.J.; Guillen, H.
Food Chem. Toxicol.
48
839-845
Links to other databases for harmol
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