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Ligand adenosine 5'-mono-O-phosphorothiolate Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information
C1 0 H1 4 N5 O6 PS
adenosine 5'-mono-O-phosphorothiolate
UBCPYVAQZGCDJO-KQYNXXCUSA-N
adenosine-5'-O-phosphorothioate, Adenosine-5'-O-phosphorotioate, adenosine-5'-phosphorothionate, adenosine 5'-phosphorothionate, adenosine 5'-thiophosphate, AMPS, cytidine 5'-phosphorothioate
Roles as Enzyme Ligand
Substrate in Enzyme-catalyzed Reactions (3 results)
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adenosine 5'-phosphorothionate + H2O = ?
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ATP + adenosine 5'-thiophosphate = ?
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adenosine 5'-mono-O-phosphorothiolate + tobramycin = diphosphate + 2''-(adenosine-5'-thiophosphoryl)-tobramycin
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Product in Enzyme-catalyzed Reactions (1 result)
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adenosine 5'-O-phosphorothioate-O-p-nitrophenyl ester + H2O = adenosine-5'-O-phosphorothioate + p-nitrophenol
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Inhibitor in Enzyme-catalyzed Reactions (2 results)
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3D Structure of Enzyme-Ligand-Complex (PDB) (2 results)
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Enzyme Kinetic Parameters
kcat Value (Turnover Number) (1 result)
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0.4
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pH 5.5, phosphohydrolase activity
KM Value (1 result)
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Ki Value (2 results)
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References & Links Literature References (6)
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Venom exonuclease-kinetics and specificity towards different nucleotide substrates
1980
Dolapchiev, L.B.
Int. J. Biol. Macromol.
2
7-12
Nucleoside inhibitors of rhodopsin kinase
1990
Palczewski, K.; Kahn, N.; Hargrave, P.A.
Biochemistry
29
6276-6282
Nucleoside phosphotransferase from malt sprouts. I. Isolation, characterization and specificity of the enzyme
1986
Billich, A.; Stockhowe, U.; Witzel, H.
Biol. Chem. Hoppe-Seyler
367
267-278
Adenosine triphosphate-adenosine-5-monophosphate phosphotransferase from normal human liver mitochondria. Isolation, chemical properties, and immunochemical comparison with Duchenne dystrophic serum aberrant adenylate kinase
1982
Hamada, M.; Sumida, M.; Okuda, H.; Watanabe, T.; Nojima, M.; Kuby, S.A.
J. Biol. Chem.
257
13120-13128
1H, 13C, and 31P nuclear magnetic resonance spectral assignments for tobramycin, 2"-(adenosine-5'-phosphoryl)-tobramycin and 2"-(adenosine-5'-thiophosphoryl)-tobramycin
1990
Van Pelt, J.E.; Mooberry, E.S.; Frey, P.A.
Arch. Biochem. Biophys.
280
284-291
Investigation of the catalytic site within the ATP-grasp domain of Clostridium symbiosum pyruvate phosphate dikinase
2001
Ye, D.; Wei, M.; McGuire, M.; Huang, K.; Kapadia, G.; Herzberg, O.; Martin, B.M.; Dunaway-Mariano, D.
J. Biol. Chem.
276
37630-37639
Links to other databases for adenosine 5'-mono-O-phosphorothiolate
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