Ligand L-carnitine

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Basic Ligand Information

Molecular Structure
Picture of L-carnitine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C7H15NO3
L-carnitine
PHIQHXFUZVPYII-ZCFIWIBFSA-O
Synonyms:
(-)carnitine, (R)-(-)-3-hydroxy-4-(trimethylamino)butyrate, (R)-3-hydroxy-4-trimethylaminobutyrate, 1-carnitine, L(-)-carnitine, L-(-)-carnitine, L-(-)carnitine


Show all pahtways known for Show all BRENDA pathways known for L-carnitine

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (26 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(R)-3-hydroxy-4-trimethylaminobutyrate + NAD+ = 3-dehydrocarnitine + NADH + H+
show the reaction diagram
-
ATP + L-carnitine + CoA = AMP + diphosphate + L-carnitinyl-CoA
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
O-fatty-acyl-L-carnitine + H2O = fatty acid + L-carnitine
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (133 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(R)-3-hydroxy-4-trimethylaminobutyrate + NAD+ = 3-dehydrocarnitine + NADH + H+
show the reaction diagram
-
L-carnitine + 2-oxoglutarate + O2 = 3-carboxy-N,N,N-trimethyl-2-oxopropan-1-aminium + succinate + CO2
show the reaction diagram
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ATP + L-carnitine + CoA = AMP + diphosphate + L-carnitinyl-CoA
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (55 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-carnitine amide + H2O = L-carnitine + NH3
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
stimulation at 3mM
-
activates at low concentrations
-
activates at low concentrations
-

Inhibitor in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
inhibits at concentrations over 6 mM
-
inhibits at concentrations over 6 mM
-
specific inhibitor
-

3D Structure of Enzyme-Ligand-Complex (PDB) (8 results)

Enzyme Kinetic Parameters

KM Value (146 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.052
-
-

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

References & Links

Links to other databases for L-carnitine

ChEBI
PubChem
ChEBI
PubChem