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Ligand formylglycinamide ribonucleotide
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Basic Ligand Information
C8H15N2O9P
formylglycinamide ribonucleotide
VDXLUNDMVKSKHO-XVFCMESISA-N
2-N-formyl-1-N-(5-phospho-D-ribosyl)glycinamide, 5'-phosphoribosyl-N-formylglycinamide, 5'-phosphoribosylformylglycinamide, beta-5'-phosphoribosyl-N-formylglycinamide, beta-5'-phosphoribosylformylglycinamide, beta-formylglycinamide ribonucleotide, formyl-beta-glycinamide ribonucleotide, formyl glycinamide ribonucleotide, formylglycinamide ribotide, N-formyl beta-glycinamide ribonucleotide, N-formylglycinamide ribotide, N2-formyl-N1-(5-phospho-beta-D-ribosyl)glycinamide, N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide
Show all BRENDA pathways known for formylglycinamide ribonucleotide
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open all tablesRoles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (8 results)
top
EC NUMBER 
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
5'-phosphoribosylformylglycinamide + L-glutamine + ATP = phosphoribosylformylglycinamidine + L-glutamate + ADP + phosphate
5'-phosphoribosylformylglycinamide + L-glutamine + ATP = phosphoribosylformylglycinamidine + L-glutamate + ADP + phosphate
formylglycinamide ribonucleotide + ATP + L-glutamine + H2O = formylglycinamidine ribonucleotide + ADP + phosphate + L-glutamate
formylglycinamide ribonucleotide + ATP + L-glutamine + H2O = formylglycinamidine ribonucleotide + ADP + phosphate + L-glutamate
ATP + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine + L-glutamate
ATP + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine + L-glutamate
In Vivo Product in Enzyme-catalyzed Reactions (5 results)
EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide = tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
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10-formyltetrahydrofolate + glycinamide ribonucleotide = tetrahydrofolate + formylglycinamide ribonucleotide
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10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide
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ATP + formate + N1-(5-phospho-beta-D-ribosyl)glycinamide = ADP + phosphate + N2-formyl-N1-(5-phospho-beta-D-ribosyl)glycinamide
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ATP + formate + N1-(5-phospho-D-ribosyl)glycinamide = ADP + H+ + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide + phosphate
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Substrate in Enzyme-catalyzed Reactions (16 results)
EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
5'-phosphoribosylformylglycinamide + ATP + L-glutamine + H2O = phosphoribosylformylglycinamidine + L-glutamate + ADP + phosphate
5'-phosphoribosylformylglycinamide + ATP + L-glutamine + H2O = phosphoribosylformylglycinamidine + L-glutamate + ADP + phosphate
5'-phosphoribosylformylglycinamide + L-glutamine + ATP = phosphoribosylformylglycinamidine + L-glutamate + ADP + phosphate
5'-phosphoribosylformylglycinamide + L-glutamine + ATP = phosphoribosylformylglycinamidine + L-glutamate + ADP + phosphate
ATP + 5'-phosphoribosylformylglycinamide + L-Gln + H2O = ADP + phosphate + 5'-phosphoribosylformylglycinamidine + L-Glu
ATP + 5'-phosphoribosylformylglycinamide + L-Gln + H2O = ADP + phosphate + 5'-phosphoribosylformylglycinamidine + L-Glu
ATP + 5'-phosphoribosylformylglycinamide + NH4+ + H2O = ADP + phosphate + 5'-phosphoribosylformylglycinamidine
ATP + 5'-phosphoribosylformylglycinamide + NH4+ + H2O = ADP + phosphate + 5'-phosphoribosylformylglycinamidine
formylglycinamide ribonucleotide + ATP + L-glutamine + H2O = formylglycinamidine ribonucleotide + ADP + phosphate + L-glutamate
formylglycinamide ribonucleotide + ATP + L-glutamine + H2O = formylglycinamidine ribonucleotide + ADP + phosphate + L-glutamate
formylglycinamide ribonucleotide + ATP + NH3 + H2O = formylglycinamidine ribonucleotide + ADP + phosphate
formylglycinamide ribonucleotide + ATP + NH3 + H2O = formylglycinamidine ribonucleotide + ADP + phosphate
ATP + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine + L-glutamate
ATP + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine + L-glutamate
Product in Enzyme-catalyzed Reactions (22 results)
EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(6R)-N10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide = (6R)-tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
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10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide = tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
0, 485727, 1312, 172166, 485712, 485713, 485714, 485716, 485718, 485721, 485724, 485725, 485728, 485729, 485731, 485734, 485735, 485738, 485742, 485715, 485736, 1413, 485717, 485719, 485737, 485739, 485740, 485711
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5'-phosphoribosylglycinamide + 10-formyl-5,8-dideazafolate = 5'-phosphoribosyl-N-formylglycinamide + 5,8-dideazafolate
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N10-formyldideazafolate + 5-phospho-D-ribosylglycinamide = dideazafolate + 5'-phosphoribosyl-N-formylglycinamide
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10-formyltetrahydrofolate + beta-5-phospho-D-ribosylglycinamide = tetrahydrofolate + beta-5'-phosphoribosyl-N-formylglycinamide
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beta-glycinamide ribonucleotide + ATP + formate = beta-formylglycinamide ribonucleotide + ADP
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formate + ATP + beta-glycinamide ribonucleotide = beta-formylglycinamide ribonucleotide + ADP
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10-formyltetrahydrofolate + carbocyclic beta-glycinamide ribonucleotide = tetrahydrofolate + formyl glycinamide ribonucleotide
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10-formyltetrahydrofolate + (alpha,beta)-glycinamide ribonucleotide = tetrahydrofolate + formylglycinamide ribonucleotide
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10-formyltetrahydrofolate + glycinamide ribonucleotide = tetrahydrofolate + formylglycinamide ribonucleotide
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N10-formyl-5-deazafolate + glycinamide ribonucleotide = formylglycinamide ribonucleotide + 5-deazafolate
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N10-formyl-8-deazafolate + glycinamide ribonucleotide = formylglycinamide ribonucleotide + 8-deazafolate
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N10-formylfolate + glycinamide ribonucleotide = folate + formylglycinamide ribonucleotide
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N5,N10-anhydroformyltetrahydrofolic acid + glycinamide ribonucleotide = formylglycinamide ribonucleotide + ?
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inosinic acid + glycinamide ribotide + H2O = 5-amino-4-imidazolecarboxamide ribotide + formylglycinamide ribotide
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N5,N10-anhydroformyl-5,6,7,8tetrahydrofolic acid + 2-amino-N-ribosylacetamide 5'-phosphate + H2O = formylglycinamide ribotide + tetrahydrofolic acid + 2-formamido-N-ribosylacetamide 5'-phosphate
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N5,N10-anhydroformyltetrahydrofolate + glycinamide ribotide + H2O = N10-formyltetrahydrofolate + formylglycinamide ribotide
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10-formyl-5,8-dideazafolate + beta-glycinamide ribonucleotide = 5,8-dideazafolate + N-formyl beta-glycinamide ribonucleotide
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10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide
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N5,N10-anhydroformyltetrahydrofolic acid + glycinamide ribonucleotide = N10-formyltetrahydrofolic acid + formylglycinamide ribonucleotide
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ATP + formate + N1-(5-phospho-beta-D-ribosyl)glycinamide = ADP + phosphate + N2-formyl-N1-(5-phospho-beta-D-ribosyl)glycinamide
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ATP + formate + N1-(5-phospho-D-ribosyl)glycinamide = ADP + H+ + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide + phosphate
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3D Structure of Enzyme-Ligand-Complex (PDB) (28 results)
EC NUMBER
ENZYME 3D STRUCTURE
Enzyme Kinetic Parameters
KM Value (7 results)
EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
References & Links
Literature References (44)
Links to other databases for formylglycinamide ribonucleotide
ChEBI
PubChem
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Release 2023.1 (January 2023)
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