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Ligand acetoacyl-[acyl-carrier protein]

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

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Show Natural Product (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.180

acyl-CoA + malonyl-[acyl-carrier protein] = acetoacyl-[acyl-carrier protein] + CoA + CO2

0

-

Product in Enzyme-catalyzed Reactions (3 results)

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Show Product (3 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.180

acyl-CoA + malonyl-[acyl-carrier protein] = acetoacyl-[acyl-carrier protein] + CoA + CO2

0

-

2.3.1.41

acetyl-CoA + malonyl-[acyl-carrier protein] = acetoacyl-[acyl-carrier protein] + CO2 + CoA

486939

-

2.3.1.41

acetyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = acetoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]

0, 486914, 486915, 486919, 486921, 486946, 486931

-

2.3.1.41

2 entries

Enzyme Kinetic Parameters

References & Links

Literature References (7)

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Show Reference (7 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

486914

5327099

Studies on the mechanism of fatty acid synthesis. XVI. Preparation and general properties of acyl-malonyl acyl carrier protein-condensing enzyme from Escherichia coli

1966

Toomey, R.E.; Wakil, S.J.

J. Biol. Chem.

241

1159-1165

486915

-

beta-Ketoacyl acyl carrier protein synthase

1969

Alberts, A.W.; Majerus, P.W.; Vagelos, P.R.

Methods Enzymol.

14

57-60

486919

237914

Multiple forms of beta-ketoacyl-acyl carrier protein synthetase in Escherichia coli

1975

D'Agnolo, G.; Rosenfeld, I.S.; Vagelos, P.R.

J. Biol. Chem.

250

5289-5294

486921

-

Partial purification of beta-ketoacyl-acyl acrrier protein synthase from a higher plant

1982

Schuz, R.; Ebel, J.; Hahlbrock, K.

FEBS Lett.

140

207-209

486931

1328217

Purification and characterization of 3-ketoacyl-acyl carrier protein synthase III from spinach. A condensing enzyme utilizing acetyl-coenzyme A to initiate fatty acid synthesis

1992

Clough, R.; Matthis, A.L.; Barnum, S.R.; Jaworski, J.G.

J. Biol. Chem.

267

20992-20998

486939

11375394

Identification, substrate specificity, and inhibition of the Streptococcus pneumoniae beta-ketoacyl-acyl carrier protein synthase III (FabH)

2001

Khandekar, S.S.; Gentry, D.R.; Van Aller, G.S.; Warren, P.; Xiang, H.; Silverman, C.; Doyle, M.L.; Chambers, P.A.; Konstantinidis, A.K.; Brandt, M.; Daines, R.A.; Lonsdale, J.T.

J. Biol. Chem.

276

30024-30030

486946

11959561

Purification, characterization, and identification of novel inhibitors of the beta-ketoacyl-acyl carrier protein synthase III (FabH) from Staphylococcus aureus

2002

He, X.; Reynolds, K.A.

Antimicrob. Agents Chemother.

46

1310-1318

Links to other databases for acetoacyl-[acyl-carrier protein]

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