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Ligand 5-L-glutamyl-3-carboxy-4-nitroanilide

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (8 results)

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Show Substrate (8 entries)

EC NUMBER

LITERATURE

REACTION DIAGRAM

REACTION

ENZYME 3D STRUCTURE

2.3.2.2

487933, 487934

5-L-glutamyl-3-carboxy-4-nitroanilide + 5-L-glutamyl-3-carboxy-4-nitroanilide = 5-L-glutamyl-5-L-glutamyl-3-carboxy-4-nitroanilide + 3-carboxy-4-nitroaniline

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2.3.2.2

487897, 487932, 487933, 487934, 487921

5-L-glutamyl-3-carboxy-4-nitroanilide + glycylglycine = 5-L-glutamyl-glycylglycine + 3-carboxy-4-nitroaniline

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2.3.2.2

701909

L-glutamic acid 5-(3-carboxy-4-nitroanilide) + ? = ?

-

2.3.2.2

487934

5-L-glutamyl 3-carboxy-4-nitroanilide + glucana = 5-amino-2-nitrobenzoic acid + N-(3-carboxy-4-nitrophenyl)-L-glutaminyl-L-glutamic acid

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2.3.2.2

487897, 487934

5-L-glutamyl 3-carboxy-4-nitroanilide + glycylglycine = 5-L-glutamyl-glycylglycine + 3-carboxy-4-nitroaniline

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2.3.2.2

694485

L-gamma-glutamyl-3-carboxy-4-nitroanilide + H2O = 3-carboxy-4-nitroaniline + L-glutamate

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2.3.2.2

737262

glutamyl-(3-carboxyl)-4-nitroanilide + glycylglycine = 3-carboxyl-4-nitroaniline + 5-L-glutamyl-glycylglycine

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2.3.2.2

736144

5-L-glutamyl-(3-carboxyl)-4-nitroanilide + glycylglycine = 3-carboxyl-4-nitroaniline + 5-L-glutamyl-glycylglycine

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2.3.2.2

8 entries

Inhibitor in Enzyme-catalyzed Reactions (1 result)

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Show Inhibitors (1 entry)

COMMENTARY

EC NUMBER

LITERATURE

ENZYME 3D STRUCTURE

enzyme from human tissues, not serum

2.3.2.2

487932, 487934

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Enzyme Kinetic Parameters

K_M Value (6 results)

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Show KM Value (6 entries)

COMMENTARY

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

LITERATURE

-

2.3.2.2

0.65

-

487934

-

2.3.2.2

1.09

-

487897

-

2 entries

at pH 11.0 and 30°C

2.3.2.2

26.9

-

737262

at pH 7.5 and 30°C

2.3.2.2

25.9

-

737262

at pH 9.0 and 30°C

2.3.2.2

16.7

-

737262

pH 8.0, 37°C

2.3.2.2

0.301

-

701909

References & Links

Literature References (9)

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Show Reference (9 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

487897

1978610

Purification and properties of gamma-glutamyl transpeptidase from human testis

1990

Yoshida, K.I.; Arai, K.; Kobayashi, N.; Saitoh, H.

Andrologia

22

239-246

487921

6113845

Some kinetic properties of gamma-glutamyltransferase from rabbit liver

1981

Bagrel, D.; Petitclerc, C.; Schiele, F.; Siest, G.

Biochim. Biophys. Acta

658

220-231

487932

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gamma-Glutamyltransferase. (gamma-Glutamyl)-peptide:amino acid gamma-glutamyltransferase, EC 2.3.2.2. 1. General

1983

Shaw, L.M.

Methods Enzym. Anal. , 3rd Ed. (Bergmeyer, H. U. , ed. )

3

349-352

487933

-

gamma-Glutamyltransferase. (gamma-Glutamyl)-peptide:amino acid gamma-glutamyltransferase, EC 2.3.2.2. 2. Routine method

1983

Wahlefeld, A.W.; Bergmeyer, H.U.

Methods Enzym. Anal. , 3rd Ed. (Bergmeyer, H. U. , ed. )

3

352-356

487934

-

gamma-Glutamyltransferase. (gamma-Glutamyl)-peptide:amino acid gamma-glutamyltransferase, EC 2.3.2.2. 3. IFCC reference method (provisional)

1983

Shaw, L.M.; Stromme, J.H.

Methods Enzym. Anal. , 3rd Ed. (Bergmeyer, H. U. , ed. )

3

357-364

694485

18584486

Glutamine affects glutathione recycling enzymes in a DMBA-induced breast cancer model

2008

Kaufmann, Y.; Todorova, V.K.; Luo, S.; Klimberg, V.S.

Nutr. Cancer

60

518-525

701909

19000649

A kinetic study of gamma-glutamyltransferase (GGT)-mediated S-nitrosoglutathione catabolism

2009

Angeli, V.; Tacito, A.; Paolicchi, A.; Barsacchi, R.; Franzini, M.; Baldassini, R.; Vecoli, C.; Pompella, A.; Bramanti, E.

Arch. Biochem. Biophys.

481

191-196

736144

-

Gamma-glutamyl transferases: A structural, mechanistic and physiological perspective

2014

Balakrishna, S.; Prabhune, A.

Front. Biol.

9

51-65

737262

24719567

Effect of pH on the hydrolytic kinetics of gamma-glutamyl transferase from Bacillus subtilis

2014

Balakrishna, S.; Prabhune, A.

ScientificWorldJournal

2014

216270

Links to other databases for 5-L-glutamyl-3-carboxy-4-nitroanilide

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Show Links (1 entry)

ChEBI

PubChem

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