Ligand 1,2-dioleoylphosphatidylglycerol

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Basic Ligand Information

Molecular Structure
Picture of 1,2-dioleoylphosphatidylglycerol (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C42H79O10P
1,2-dioleoylphosphatidylglycerol
DSNRWDQKZIEDDB-CLFAGFIQSA-N
Synonyms:
1,2-dioleoyl-phosphatidylglycerol, 1,2-dioleoyl-sn-glycero-3-phospho-3'-sn-glycerol

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
1,2-dioleoyl-phosphatidylglycerol + H2O = 2-oleoyl-phosphatidylglycerol + oleate
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
1,2-dioleoyl-phosphatidylglycerol + H2O = 2-oleoyl-phosphatidylglycerol + oleate
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
1,2-dioleoyl-sn-glycero-3-phosphocholine + glycerol = 1,2-dioleoyl-sn-glycero-3-phospho-3'-sn-glycerol + 1,2-dioleoyl-sn-glycero-3-phospho-1'-sn-glycerol + choline
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
solubilized ZntA is increased in the presence of negatively charged phospholipids and at slightly acidic pH. Among the most abundant naturally accuring phospholipids, only phosphatidyl-glycerol enhances the in vitro ATPase activity of TntA. Relipidation of detergent-purified ZntA with 1,2-dioleoylphosphatidyl-glycerol increases the ATPase activity 4fold compared to the purified state. Among the phosphatidylglycerol family, highest activity is observed for 1,2-dioleoyl-phosphatidylglycerol followed by 1,2-dimyristoyl-phosphatidylglycerol, 1,2-dipalmitoyl-phosphatidylglycerol and 1,2-distearoyl-phosphatidylglycerol
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Inhibitor in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
above 0.65 mM
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in vesicles with 1,2-dioleoyl-phosphatidylglycerol, 18fold activation of enzyme activity with prothrombin
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Enzyme Kinetic Parameters

KM Value (1 result)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
1
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pH 9.0, 45°C

References & Links

Links to other databases for 1,2-dioleoylphosphatidylglycerol

ChEBI
PubChem
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PubChem