Ligand Lipid

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Basic Ligand Information

Molecular Structure
Picture of Lipid (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C29H54O8PR3
Lipid

Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
lipid-linked oligosaccharide + [peptide]-L-asparagine = lipid + a glycopeptide with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine
show the reaction diagram
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Enzyme Cofactor/Cosubstrate (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
four lipid molecules can be assigned in the high-resolution structure of PSI. Three of these molecules are phosphatidylglycerol and one is monogalactosyldiacylglycerol. These molecules are embedded in the PSI complex, with the acyl chains anchored among transmembrane helices. The phosphodiester group of one of the phospholipids coordinates an antenna chlorophyll molecule
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Activator in Enzyme-catalyzed Reactions (17 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activates
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lipid component required
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from adrenal mitochondria accelerates activity
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the enzyme requires lipid inverted hexagonal structures for activity
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activity is stimulated by the presence of negatively charged lipids, which highlight the importance of the membrane environment in modulating the activity of the enzyme
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addition of lipids extracted from chloroplast membranes is necessary to reveal activity of highly delipidated enzyme fraction
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purified enzyme is completely inactive unless a lipid is added to the assay buffer containing Triton X-100
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the enzyme requires lipids for activity, complete separation of bound lipids from the enzyme leads to extensive loss of activity
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enzyme is surface activated by aggregated lipids such as mixed micelles of detergent and phospholipid
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activates
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from Escherichia coli, about 1.4fold stimulation
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Inhibitor in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
addition of total lipids from Thermoplasma acidophilum decreases activity
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above the critrical micelle concentration gives kinetic pattern that mimics competitive inhibition
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Enzyme Kinetic Parameters

References & Links

Links to other databases for Lipid

ChEBI
PubChem
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