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Ligand methylumbelliferyl-N-acetyl-alpha-D-glucosaminide

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (3 results)

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Show Substrate (3 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.2.1.50

4-methylumbelliferyl N-acetyl-alpha-D-glucosaminide + H2O = 4-methylumbelliferone + N-acetyl-alpha-D-glucosamine

751421, 751986, 749725

-

3.2.1.50

4-methylumbelliferyl-2-acetamide-2-deoxy-alpha-D-glucopyranoside + H2O = 4-methylumbelliferol + 2-acetamide-2-deoxy-alpha-D-glucopyranose

679282

-

3.2.1.50

methylumbelliferyl-N-acetyl-alpha-D-glucosaminide + H2O = methylumbelliferone + N-acetyl-alpha-D-glucosamine

208690, 208693

-

3.2.1.50

3 entries

Enzyme Kinetic Parameters

K_M Value (2 results)

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Show KM Value (2 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

3.2.1.50

0.13

0.2

-

208690

3.2.1.50

0.22

-

purified enzyme

208693

3.2.1.50

2 entries

References & Links

Literature References (6)

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Show Reference (6 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

208690

8444316

Micromethod determination of N-acetyl-alpha-D-glucosaminidase in human leukocytes and study of some of its characteristics

1993

Den Tandt, W.R.; Scharpe, S.

Int. J. Biochem.

25

209-212

208693

10833408

Purification and characterization of recombinant human alpha-N-acetylglucosaminidase secreted by chinese hamster ovary cells

2000

Zhao, K.W.; Neufeld, E.F.

Protein Expr. Purif.

19

202-211

679282

16712827

Twelve different enzyme assays on dried-blood filter paper samples for detection of patients with selected inherited lysosomal storage diseases

2006

Civallero, G.; Michelin, K.; de Mari, J.; Viapiana, M.; Burin, M.; Coelho, J.C.; Giugliani, R.

Clin. Chim. Acta

372

98-102

749725

25381911

alpha-N-acetylglucosaminidase from Bifidobacterium bifidum specifically hydrolyzes alpha-linked N-acetylglucosamine at nonreducing terminus of O-glycan on gastric mucin

2015

Shimada, Y.; Watanabe, Y.; Wakinaka, T.; Funeno, Y.; Kubota, M.; Chaiwangsri, T.; Kurihara, S.; Yamamoto, K.; Katayama, T.; Ashida, H.

Appl. Microbiol. Biotechnol.

99

3941-3948

751421

30802506

Structural characterization of the alpha-N-acetylglucosaminidase, a key enzyme in the pathogenesis of Sanfilippo syndrome B

2019

Birrane, G.; Dassier, A.L.; Romashko, A.; Lundberg, D.; Holmes, K.; Cottle, T.; Norton, A.W.; Zhang, B.; Concino, M.F.; Meiyappan, M.

J. Struct. Biol.

205

65-71

751986

30657762

BMN 250, a fusion of lysosomal alpha-N-acetylglucosaminidase with IGF2, exhibits different patterns of cellular uptake into critical cell types of Sanfilippo syndrome B disease pathogenesis

2019

Yogalingam, G.; Luu, A.R.; Prill, H.; Lo, M.J.; Yip, B.; Holtzinger, J.; Christianson, T.; Aoyagi-Scharber, M.; Lawrence, R.; Crawford, B.E.; LeBowitz, J.H.

PLoS ONE

14

e0207836

Links to other databases for methylumbelliferyl-N-acetyl-alpha-D-glucosaminide

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Show Links (1 entry)

ChEBI

PubChem

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