Ligand D-mannose 1-phosphate

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Basic Ligand Information

Molecular Structure
Picture of D-mannose 1-phosphate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H13O9P
D-mannose 1-phosphate
HXXFSFRBOHSIMQ-QTVWNMPRSA-N
Synonyms:
D-mannose-1-phosphate, D-mannose phosphate, Man-1-phosphate, mannose-1-phosphate, mannose 1-phospahte, mannose 1-phosphate

Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
GDPmannose + phosphate = GDP + mannose 1-phosphate
show the reaction diagram
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GDP-mannose + H2O = GMP + D-mannose-1-phosphate
show the reaction diagram
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D-mannose 6-phosphate = D-mannose 1-phosphate
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (15 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
3-phospho-D-glyceroyl phosphate + D-mannose 1-phosphate = 3-phospho-D-glycerate + D-mannose 1,6-bisphosphate
show the reaction diagram
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GTP + D-mannose 1-phosphate = diphosphate + GDP-mannose
show the reaction diagram
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GTP + D-mannose 1-phosphate = diphosphate + GDP-mannose
show the reaction diagram
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UTP + D-mannose 1-phosphate = diphosphate + UDP-mannose
show the reaction diagram
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D-Mannose 1-phosphate = D-Mannose 6-phosphate
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (23 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
phosphohistidinoprotein + D-mannose = histidine-containing protein + D-mannose phosphate
show the reaction diagram
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ATP + mannose = ADP + mannose 1-phosphate
show the reaction diagram
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phosphoramidate + mannose = mannose 1-phosphate + NH3
show the reaction diagram
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GDPmannose + phosphate = GDP + mannose 1-phosphate
show the reaction diagram
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diphosphate + UDP-mannose = UTP + D-mannose 1-phosphate
show the reaction diagram
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GDP-Man + H2O = Man-1-phosphate + GMP
show the reaction diagram
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GDP-mannose + H2O = GMP + D-mannose-1-phosphate
show the reaction diagram
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D-mannose 6-phosphate = D-mannose 1-phosphate
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (13 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
strong inhibition
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noncompetitive inhibition of GDP-glucose phosphorolysis
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0.07 mM: 18% inhibition in presence of 3.5 mM GDPglucose, 40% inhibition in presence of 0.7 mM GDPglucose, no inhibition in presence of more than 7 mM GDPglucose
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1.25 mM: 22% inhibition, 4.2 mM: 40% inhibition
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strong competitive inhibitor of hydrolysis of glucose 6-phosphate
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0.5 mM, 81.9% of initial activity
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (4 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.2
-
pH 7.0, 37°C
22.5
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KM Value (21 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.542
-
pH 7.0, 37°C

Ki Value (4 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.06
-
pH 7.5, 37°C
1.35
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25°C, pH 7.6, substrate inhibition at high concentrations

References & Links

Links to other databases for D-mannose 1-phosphate

ChEBI
PubChem
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PubChem