Ligand 5beta-androstane-3alpha,17beta-diol

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Basic Ligand Information

Molecular Structure
Picture of 5beta-androstane-3alpha,17beta-diol (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C19H32O2
5beta-androstane-3alpha,17beta-diol
CBMYJHIOYJEBSB-GCXXXECGSA-N
Synonyms:
(3R,5R,8R,9S,10S,13S,14S,17S)-10,13-Dimethyl-hexadecahydro-cyclopenta[a]phenanthrene-3,17-diol, 5beta-androstan-17beta,3alpha-diol, 5beta-androstane-17beta-ol-3-one

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
5beta-androstane-3alpha,17beta-diol + NADP+ = 5beta-androstan-17beta-ol-3-one + NADPH + H+
show the reaction diagram
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5beta-androstane-3alpha,17beta-diol + NADP+ = 5beta-androstane-3alpha-ol-17-one + NADPH
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (13 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
5beta-androstane-3alpha,17beta-diol + NADP+ = 5beta-androstane-17beta-ol-3-one + NADPH
show the reaction diagram
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5beta-androstane-3alpha,17beta-diol + NADP+ = 5beta-androstane-17beta-ol-3-one + NADPH
show the reaction diagram
-
5beta-androstane-3alpha,17beta-diol + NADP+ = 5beta-androstan-17beta-ol-3-one + NADPH + H+
show the reaction diagram
-
5beta-androstane-3alpha,17beta-diol + NAD+ = ?
show the reaction diagram
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5beta-androstane-3alpha,17beta-diol + UDP-glucuronate = UDP + 5beta-androstane-3alpha,17beta-diol O-glucuronide
show the reaction diagram
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3'-phosphoadenylylsulfate + 5beta-androstane-3alpha,17beta-diol = adenosine 3',5'-bisphosphate + ?
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
5beta-androstane-3beta,17beta-diol + NADP+ = 5beta-androstane-17beta-ol-3-one + NADPH + H+
show the reaction diagram
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5beta-androstan-3alpha-ol-17-one + NADH = 5beta-androstane-3alpha,17beta-diol + NAD+
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
0.01 mM, 83% inhibition, reaction with 0.002 mM estradiol
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (6 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.012
-
pH 7.4, 25°C, recombinant enzyme

KM Value (9 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0039
-
pH 7.4, 25°C, recombinant enzyme
0.011
-
-

References & Links

Links to other databases for 5beta-androstane-3alpha,17beta-diol

ChEBI
PubChem
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PubChem