Ligand hyaluronic acid

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Basic Ligand Information

Molecular Structure
Picture of hyaluronic acid (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C14H23NO12
hyaluronic acid
LJORHONFMDUUHP-VOGNPWKQSA-N
Synonyms:
hyaluronate, hyaluronic acid disaccharide

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
hyaluronic acid + H2O = ?
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (24 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
hyaluronic acid + H2O = ?
show the reaction diagram
-
hyaluronic acid + H2O = N-acetylglucosamine + ?
show the reaction diagram
-
hyaluronic acid = ?
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Activator in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activates single-chain inactivate zymogen to the two-chain active enzyme
-

Inhibitor in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
molecular weight of about 8.9 kDa
-
plasmalogen-specific PLA2
-
slight
-
inhibitory at high concentrations (0.73 g/l)
-
binds to the enzyme in vivo
-
substrate inhibition above 7.5 mg/ml
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (8 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
1.3
-
mutant K130C, pH not specified in the publication, temperature not specified in the publication

KM Value (16 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.438
-
mutant K130C, pH not specified in the publication, temperature not specified in the publication

References & Links

Links to other databases for hyaluronic acid

ChEBI
PubChem
-
PubChem