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Ligand 14-demethyllanosterol

Basic Ligand Information

Molecular Structure

Related pathways

Show all BRENDA pathways known for 14-demethyllanosterol

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Natural Substrate (2 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.14.18.9

4,4-dimethyl-zymosterol + reduced acceptor + O2 = 4-hydroxymethyl,4-methyl-zymosterol + acceptor + H2O

675262

-

1.3.1.70

4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+ = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+

764764, 765069

-

In Vivo Product in Enzyme-catalyzed Reactions (3 results)

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Show Natural Product (3 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.14.14.154

lanosterol + [reduced NADPH-hemoprotein reductase] + O2 = 4,4-dimethylzymosterol + formate + [oxidized NADPH-hemoprotein reductase] + H2O

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-

1.3.1.70

4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+ = 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+

-

-

1.3.1.70

4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH = 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+

-

-

1.3.1.70

2 entries

Substrate in Enzyme-catalyzed Reactions (4 results)

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Show Substrate (4 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.14.18.9

4,4-dimethyl-zymosterol + reduced acceptor + O2 = 4-hydroxymethyl,4-methyl-zymosterol + acceptor + H2O

675262

-

1.14.18.9

4,4-dimethyl-zymosterol + reduced acceptor + O2 = ?

658182

-

1.14.18.9

2 entries

1.3.1.70

4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+ = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+

764764, 765069

-

1.3.1.72

4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADPH = 4,4-dimethyl-5alpha-cholesta-8-en-3beta-ol + NADP+

288496, 690082

-

Product in Enzyme-catalyzed Reactions (7 results)

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Show Product (7 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.14.14.154

lanosterol + [reduced NADPH-hemoprotein reductase] + O2 = 4,4-dimethylzymosterol + formate + [oxidized NADPH-hemoprotein reductase] + H2O

-

-

1.14.15.36

lanosterol + 6 reduced ferredoxin [iron-sulfur] cluster + 6 H+ + 3 O2 = 4,4-dimethylzymosterol + formate + 6 oxidized ferredoxin [iron-sulfur] cluster + 4 H2O

-

-

1.14.15.36

oxolanosterol + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = 4,4-dimethylzymosterol + formate + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O

-

-

1.3.1.70

4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+ = 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+

-

-

1.3.1.70

4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH = 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+

-

-

1.3.1.70

4,4-dimethylcholesta-8,12,24-trien-3beta-ol + NADPH + H+ = 4,4-dimethylzymosterol + NADP+

-

-

1.14.15.36

2 entries

1.3.1.70

3 entries

5.4.99.7

27-norsqualene = 30-norlanosterol + 26-normalabaricatriene

-

-

Enzyme Kinetic Parameters

References & Links

Literature References (7)

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Show Reference (7 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

288496

9291139

Cholesterol biosynthesis from lanosterol: development of a novel assay method and characterization of rat liver microsomal lanosterol DELTA24-reductase

1997

Bae, S.H.; Paik, Y.K.

Biochem. J.

326

609-616

658182

12880870

Enzymological properties of sterol-C4-methyl-oxidase of yeast sterol biosynthesis

2003

Darnet, S.; Rahier, A.

Biochim. Biophys. Acta

1633

106-117

675262

15995173

Erg28p is a key protein in the yeast sterol biosynthetic enzyme complex

2005

Mo, C.; Bard, M.

J. Lipid Res.

46

1991-1998

690082

18394665

Homology modelling of human DHCR24 (seladin-1) and analysis of its binding properties through molecular docking and dynamics simulations

2008

Pedretti, A.; Bocci, E.; Maggi, R.; Vistoli, G.

Steroids

73

708-719

764764

29387050

Abnormal ergosterol biosynthesis activates transcriptional responses to antifungal azoles

2018

Hu, C.; Zhou, M.; Wang, W.; Sun, X.; Yarden, O.; Li, S.

Front. Microbiol.

9

9-9

765069

31911440

Twin enzymes, divergent control The cholesterogenic enzymes DHCR14 and LBR are differentially regulated transcriptionally and post-translationally

2020

Capell-Hattam, I.M.; Sharpe, L.J.; Qian, L.; Hart-Smith, G.; Prabhu, A.V.; Brown, A.J.

J. Biol. Chem.

295

2850-2865

765069

31911440

Twin enzymes, divergent control The cholesterogenic enzymes DHCR14 and LBR are differentially regulated transcriptionally and post-translationally

2020

Capell-Hattam, I.M.; Sharpe, L.J.; Qian, L.; Hart-Smith, G.; Prabhu, A.V.; Brown, A.J.

J. Biol. Chem.

295

2850-2865

765069

2 entries

Links to other databases for 14-demethyllanosterol

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Show Links (1 entry)