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BRENDA support

Ligand estriol

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Basic Ligand Information

Molecular Structure
Picture of estriol (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C18H24O3
estriol
PROQIPRRNZUXQM-ZXXIGWHRSA-N
Synonyms:
(16alpha,17beta)-estra-1(10),2,4-triene-3,16,17-triol, 1,3,5(10)estatriene-3,16alpha,17beta-triol, 16alpha-hydroxy-17beta-estradiol

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
estriol + 6 reduced ferredoxin [iron-sulfur] cluster + 6 H+ + 3 O2 = ? + formate + 6 oxidized ferredoxin [iron-sulfur] cluster + 4 H2O
show the reaction diagram
-
UDP-glucuronate + estriol = UDP + estriol beta-D-glucuronoside
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (13 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
estriol + H2O = ?
show the reaction diagram
-
estriol + 6 reduced ferredoxin [iron-sulfur] cluster + 6 H+ + 3 O2 = ? + formate + 6 oxidized ferredoxin [iron-sulfur] cluster + 4 H2O
show the reaction diagram
-
3'-phosphoadenylylsulfate + estriol = adenosine 3',5'-bisphosphate + estriol sulfate
show the reaction diagram
-
3'-phosphoadenylylsulfate + estriol = adenosine 3',5'-bisphosphate + estriol sulfate
show the reaction diagram
-
3'-phosphoadenylylsulfate + estriol = adenosine 3',5'-bisphosphate + estriol 3-sulfate
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
16alpha-hydroxytestosterone + 3 O2 + 3 reduced flavoprotein = (16alpha,17beta)-estra-1(10),2,4-triene-3,16,17-triol + formate + 4 H2O + 3 oxidized flavoprotein
show the reaction diagram
-
estriol 3-sulfate + H2O = estriol + sulfate
show the reaction diagram
-
estriol 3-glucuronide + H2O = estriol + D-glucuronic acid
show the reaction diagram
-

Inhibitor in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
i.e. 16alpha-hydroxyestradiol
-
a substrate analogue
-
linear noncompetitive inhibition towards estrone
-

3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (1 result)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.167
-
pH 7.5, 37°C

KM Value (6 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.207
-
-
0.35
-
pH 7.5, 37°C

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0082
-
pH 8.1, 37°C

IC50 Value (5 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.025
-
in 0.1 M potassium phosphate, pH 7.4, at 25°C

References & Links

Links to other databases for estriol

ChEBI
PubChem
ChEBI
PubChem