Any feedback?
Please rate this page
(ligand.php)
(0/150)

BRENDA support

Ligand adrenaline

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

Basic Ligand Information

Molecular Structure
Picture of adrenaline (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
Molfile
C9H13NO3
adrenaline
UCTWMZQNUQWSLP-UHFFFAOYSA-N
Synonyms:
adrenalin, DL-adrenaline, DL-Epinephrine, epinephrine

Related pathways

Pathway Source
Pathways


Show all pahtways known for Show all BRENDA pathways known for adrenaline

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
epinephrine + H2O + O2 = ?
show the reaction diagram
-
epinephrine + O2 = ?
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
S-adenosyl-L-methionine + norepinephrine = S-adenosyl-L-homocysteine + epinephrine
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (20 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
epinephrine + O2 = ?
show the reaction diagram
-
DL-adrenaline + O2 = ?
show the reaction diagram
-
epinephrine + O2 = ?
show the reaction diagram
-
epinephrine + Fe2+ + O2 = ?
show the reaction diagram
-
epinephrine + H2O + O2 = ?
show the reaction diagram
-
epinephrine + O2 = ?
show the reaction diagram
-
epinephrine + S-adenosyl-L-methionine = ? + D-adenosylhomocysteine
show the reaction diagram
-
acetyl-CoA + epinephrine = CoA + N-acetyl-epinephrine
show the reaction diagram
-
4-nitrophenyl sulfate + epinephrine = ? + 4-nitrophenol
show the reaction diagram
-
3'-phosphoadenylylsulfate + epinephrine = adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Activator in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activation is independent of the concentration of tyrosine, maximal activation achieved with 7-10 micromolar of adrenaline
-
promotes dephosphorylation of lipin, but has no effect on PAP activity, markedly increases amounts of lipin and PAP activity in microsomes
-
intrabrachial infusion of epinephrine (0.1 to 0.3 microg/100 ml per minute) induces greater t-PA release in normotensive subjects as compared with essential hypertensive patients
-
hypothesis: stimulate Na+/K+ transport via specific receptor inputs
-

Inhibitor in Enzyme-catalyzed Reactions (25 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
0.17 mM, 50% inhibition, noncompetitive
-
IC50: 0.98 mM
-
competitive inhibition with respect to Fe2+
-
0.13 mM, 50% inhibition
-
leads to phosphorylation of enzyme
-
promotes dephosphorylation of lipin, but has no effect on PAP activity, markedly decreases amounts of lipin and PAP activity in the soluble fraction
-
brain enzyme, at high concentrations, 12.5 mM: 65% inhibition
-
30% inhibition at 4 mM
-
overexposure to epinephrine inactivates adenylate cyclase
-
0.5 mM epinephrine added for 20 min, decreases the activity of the enzyme by around 50%. Treatment with Rp-cAMP, indomethacin, PP2, SB202190, and PD98059 completely abrogate the effect of epinephrine
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (5 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.122
-
pH 5.5, 37°C

KM Value (23 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
1.13
-
-
0.43
-
pH 5.5, 37°C

Ki Value (8 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.1
-
-
0.054
-
-

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.98
-
IC50: 0.98 mM

References & Links

Links to other databases for adrenaline

EXTERNAL LINKS