Ligand hydrogen sulfide

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Basic Ligand Information

Molecular Structure
Picture of hydrogen sulfide (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
H2S
hydrogen sulfide
RWSOTUBLDIXVET-UHFFFAOYSA-N
Synonyms:
bisulfide, H2S, HS-, hydrogen-sulfide, hydrogensulfide, hydrosulfide, SH-, SH2, Sulfide, sulphur hydride
Pathway Source
Pathways
MetaCyc
4,4'-disulfanediyldibutanoate degradation, assimilatory sulfate reduction I, assimilatory sulfate reduction II, assimilatory sulfate reduction III, carbon disulfide oxidation I (anaerobic) more


Show all pahtways known for Show all BRENDA pathways known for hydrogen sulfide

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (98 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
hydrogen sulfide + glutathione + a quinone = S-sulfanylglutathione + a quinol
show the reaction diagram
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hydrogen sulfide + oxidized ferredoxin + H2O = sulfite + reduced ferredoxin + H+
show the reaction diagram
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hydrogen sulfide + a [DsrC protein]-disulfide + acceptor + H2O = sulfite + a [DsrC protein]-dithiol + reduced acceptor + H+
show the reaction diagram
acetyl-CoA + hydrogen sulfide = CoA + thioacetate
show the reaction diagram
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O-phospho-L-seryl-tRNACys + sulfide = L-cysteinyl-tRNACys + phosphate
show the reaction diagram
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sulfide + tRNA-uridine = tRNA-4-thiouridine
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (41 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
sulfur = H2S
show the reaction diagram
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5 sulfur + 2 O2 + 2 H2O + 4 H+ = sulfite + thiosulfate + 2 sulfide
show the reaction diagram
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sulfite + 6 ferrocytochrome c + 6 H+ = H2S + 3 H2O + 6 ferricytochrome c
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sulfur + NAD(P)H + H+ = hydrogen sulfide + NAD(P)+
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(sulfide)n+1 + NADPH + H+ = hydrogen sulfide + (sulfide)n + NADP+
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thiosulfate + 2 ferrocytochrome c3 = sulfite + hydrogen sulfide + 2 ferricytochrome c3
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methanethiol + O2 + H2O = formaldehyde + H2S + H2O2
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sulfite + reduced coenzyme F420 = hydrogen sulfide + oxidized coenzyme F420
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sulfite + 6 ferrocytochrome c + 6 H+ = sulfide + 6 ferricytochrome c + 3 H2O
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3-mercaptopyruvate + cyanide = H2S + ?
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thiosulfate + glutathione = sulfite + glutathione disulfide + sulfide
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thiosulfate + 2 dithioerythritol = sulfite + dithioerythritol disulfide + sulfide
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carbonyl sulfide + H2O = hydrogen sulfide + CO2
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D-cysteine + H2O = sulfide + NH3 + pyruvate
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L-cysteine + H2O = sulfide + NH3 + pyruvate
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D-cysteine + H2O = sulfide + NH3 + pyruvate
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L-homocysteine + H2O = hydrogen sulfide + NH3 + 2-oxobutanoate
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L-cysteine + H2O = sulfide + NH3 + pyruvate
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Substrate in Enzyme-catalyzed Reactions (683 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
sulfide + O2 = sulfur + H2O2
show the reaction diagram
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sulfite + hydrogen sulfide + menaquinone = thiosulfate + menaquinol
show the reaction diagram
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hydrogen sulfide + a [DsrC protein]-disulfide + acceptor + H2O = sulfite + a [DsrC protein]-dithiol + reduced acceptor + H+
show the reaction diagram
acetyl-CoA + hydrogen sulfide = CoA + thioacetate
show the reaction diagram
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NAD+ + glycine + sulfide = nicotinamide + ADP-5-ethyl-4-methylthiazole-2-carboxylate + 3 H2O
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O-acetyl-L-serine + sulfide = 2-amino-3-sulfanylpropanoic acid + acetate
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O-succinyl-L-homoserine + H2S = L-homocysteine + succinate
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sulfide + adenylated-tRNA-uridine(position8) = tRNA-4-thiouridine(position8) + ?
show the reaction diagram
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3-phospho-L-serine + sulfide = ?
show the reaction diagram
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L-Seryl-tRNASec + sulfide = ?
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horse heart cytochrome c + sulfide = ?
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O-Acetyl-L-serine + H2S = Cysteine + acetate
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O-acetyl-D-serine + sulfide = D-cysteine + ?
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3-chloro-D-alanine + H2S = D-cysteine + HCl
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Product in Enzyme-catalyzed Reactions (191 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
H2 + sulfur = H2S
show the reaction diagram
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5 sulfur + 2 O2 + 2 H2O + 4 H+ = sulfite + thiosulfate + 2 sulfide
show the reaction diagram
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(sulfide)n+1 + NADPH + H+ = hydrogen sulfide + (sulfide)n + NADP+
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sulfur + reduced benzyl viologen + H+ = sulfide + oxidized benzyl viologen
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thiosulfate + menaquinol = sulfite + hydrogen sulfide + menaquinone
show the reaction diagram
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L-homocysteine + KCN = gamma-cyano-alpha-aminobutyric acid + H2S
show the reaction diagram
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L-cysteine + dithiothreitol = S-(2,3-hydroxy-4-thiobutyl)-L-cysteine + sulfide
show the reaction diagram
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cysteine + cyanide = cyanoalanine + H2S
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thiosulfate + glutathione = sulfite + glutathione disulfide + sulfide
show the reaction diagram
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L-cysteine = L-alanine + sulfide
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carbonyl sulfide + H2O = hydrogen sulfide + CO2
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benzoyl-thiocarbamic acid + H2O = N-benzoyl-Gly + SH2
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D-cysteine + H2O = sulfide + NH3 + pyruvate
show the reaction diagram
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L-Cys + sulfite = L-cysteate + H2S
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D-cysteine + H2O = sulfide + NH3 + pyruvate
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (18 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activates at 0.01 M
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activating at 0.1 mM, inhibitory above 0.3 mM, in human colon cancer cell line HT-29
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Inhibitor in Enzyme-catalyzed Reactions (65 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
at high sulfide concentrations, enzymic inhibition is observed above 0.25 mM (20% inhibition at 0.3 mM sulfide)
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sulfide, elemental sulfur, elemental selenium or hydroxylamine required in catalytic amount, inhibition when added over a critical concentration (with the exception of hydroxylamine)
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substrate analogue, formation of a green complex upon binding
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partial
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reduction of sulfite, nitrite, hydroxylamine by reduced methyl viologen
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the enzyme activity decreases when the ambient sulfide concentration exceeds 0.3 mM
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Na2S at 0.5 mM inactivates completely
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product inhibition, competitive versus both substrates
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optimal sulfide concentration for 4-thiouridine modification of tRNAPhe is about 50 mM. Higher sulfide concentrations are inhibitory
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Zn2+ but not Cd2+, Ca2+ or Mg2+ could counteract the inhibitory effect
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1-3 mM, complete inhibition
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Metals and Ions (54 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE